External Cross-validation of Two Ciprofloxacin Population Pharmacokinetic Models in Patients in Intensive Care [0.03%]
重症监护患者中两种环丙沙星群体药代动力学模型的外部交叉验证
Irma M Rigter,Eleonora L Swart,Roger J Brüggemann et al.
Irma M Rigter et al.
Background: The population pharmacokinetic (popPK) variability of ciprofloxacin in patients in intensive care units (ICUs) is unclear. Two popPK models of ciprofloxacin in those in the ICU were externally cross-validated ...
Beating Drug Tests by Ingesting Detoxifying Agents or Adulterating Urine in vitro: Are These Practices Effective? [0.03%]
服用解毒剂或体外处理尿液以通过药物检测：这些做法有效吗？
Amitava Dasgupta
Amitava Dasgupta
Background: Workplace drug testing aims to deter employees from abusing drugs. Nevertheless, people try to beat such tests in several ways. Therefore, it is important for drug-testing laboratories to identify adulterated ...
Rivaroxaban Plasma Concentrations Cannot be Predicted from Coagulation Assays: Real-Life Experience From a Tertiary Hospital in New Zealand [0.03%]
新西兰三级医院的现实经验：凝血试验无法预测利伐沙班的血药浓度
Yassar Alamri,Milan Sundermann,Adele O&#x;Mahony et al.
Yassar Alamri et al.
Background: The use of direct oral anticoagulants, such as rivaroxaban, is preferred over vitamin K antagonists. Several clinical scenarios highlighting potential benefits of measuring plasma concentrations have been repo...
In vitro Study of the Effects of Acetylcysteine on the International Normalized Ratio Over Time [0.03%]
N-乙酰半胱氨酸对不同时间凝血酶原时间国际标准化比率的体外实验研究
Messia Nazar,Jenny E Kootstra-Ros,Daniel J Touw et al.
Messia Nazar et al.
Background: Patients with paracetamol poisoning are treated with acetylcysteine. In paracetamol-poisoned patients without hepatocellular injury, an increased international normalized ratio (INR) was observed after acetylc...
Unveiling Cardiac Complications: A Case of Amisulpride Overdose Leading to Bradycardia, QT-Prolongation, and Torsade de Pointes Tachycardia [0.03%]
阿米舒普利 overdose导致心动过缓、QT间期延长和尖端扭转型室速的病例报告
Michael Kunz,Lea Wagmann,Michael Schuster et al.
Michael Kunz et al.
Suicide attempts involving self-poisoning with benzodiazepines, antipsychotic drugs, or antidepressants are prevalent in emergency departments and intensive care units. Managing these patients is often complex and relies predominantly on lo...
Safa Souissi,Syrine Ben Hammamia,Mouna Ben Sassi et al.
Safa Souissi et al.
Background: Vancomycin is a glycopeptide antibiotic indicated in patients suffering from infections caused by gram-positive bacteria. Therapeutic drug monitoring is crucial because of its high interindividual variability,...
Karel K M Koudijs,Oumaima Etsouli,Costanza L Vallerga et al.
Karel K M Koudijs et al.
Background: Common genetic variants in CYP3A4 together only explain a limited amount of the variability in tacrolimus clearance. This cross-sectional study aimed to explore the extent to which pharmacokinetic variability ...
Pharmacokinetic Characterization of Rituximab in Patients with Glomerular Diseases [0.03%]
利妥昔单抗在肾小球病患者中的药动学特征分析
María Larrosa-García,Irene Agraz Pamplona,María Teresa Sanz Martínez et al.
María Larrosa-García et al.
Background: Rituximab is commonly used to treat patients with primary glomerular diseases; however, its pharmacokinetics in this population have not been fully described yet. ...
"Goofballing": An Emerging Threat With Clinical Challenges-A Short Communication [0.03%]
"嬉皮行为": 一个具有临床挑战性的新兴威胁-简短通讯
Guillaume Drevin,Marie Briet,Séverine Ferec et al.
Guillaume Drevin et al.
Background: The coinjection of methamphetamine and opioids, known as "goofballing," is an emerging practice among people who inject drugs. This combination poses significant clinical challenges due to the opposing pharmac...
Optimization of Teicoplanin Dosing Regimen in Adult Patients Using an Externally Evaluated Population Pharmacokinetic Model [0.03%]
基于外部验证的群体药代动力学模型指导下(teicoplanin)成人剂量优化研究
Xiaojing Li,Qiang Sun,Genzhu Wang et al.
Xiaojing Li et al.
Background: This study aimed to identify population pharmacokinetic models suitable for optimizing individualized teicoplanin dosing regimens in adult Chinese patients. ...