Quantification of Ceftazidime in the Vitreous Humor Using Ultra-performance Convergence Chromatography-Tandem Mass Spectrometry [0.03%]
应用超高效合相色谱-串联质谱法测定玻璃体液中头孢他啶的含量
Soma Bahmany,Michele Manzulli,Boudewijn van der Wel et al.
Soma Bahmany et al.
Background: Patients with suspected postoperative bacterial endophthalmitis are at a high risk of vision loss if not treated immediately and adequately. Initial treatment typically involves the intravitreal administration...
Real-World Adalimumab Trough Levels, Antidrug Antibody Levels, and Disease Activity in Rheumatoid Arthritis [0.03%]
真实世界的阿达木单抗谷浓度、抗药抗体浓度和类风湿关节炎的疾病活动度
Juul M Cox,Hazar El Achaouch,T Martijn Kuijper et al.
Juul M Cox et al.
Background: The association between adalimumab trough levels and disease activity was evaluated in a real-world population with rheumatoid arthritis (RA). The distribution of adalimumab serum levels, proportion of patient...
Effects of Different Linezolid Concentration Levels on Hematologic Side Effects: A New Target for Therapeutic Drug Monitoring [0.03%]
不同浓度利奈唑胺对血液系统不良反应的影响：治疗药物监测的新目标
Tingting Liu,Bing Liu,Guangrui Geng et al.
Tingting Liu et al.
Background: The emergence of a linezolid minimum inhibitory concentration creep (2-4 mg/L) necessitates higher trough concentrations (Cmin), which may increase the risk of hematological side effects. Evaluating the effect...
A Scoping Review on Vancomycin Monitoring in Intermittent Hemodialysis: Current Evidence and Future Perspectives [0.03%]
间歇血液透析万古霉素监测的综述：现有证据及未来展望
Nathália Rodrigues Corrêa,Victor Kaneko Matsuno,Ronaldo Morales Junior et al.
Nathália Rodrigues Corrêa et al.
Background: Despite the general recommendation of AUC0-24h/MIC ratio of 400-600 mg·h/L for vancomycin (VAN) effectiveness, there is no strong evidence of this index for patients undergoing renal replacement therapy (RRT)...
Relationship Between Clozapine:Norclozapine Ratio, Cognitive Function, and Employment Status in Patients with Treatment-Resistant Schizophrenia [0.03%]
氯氮平治疗难治性精神分裂症患者的血药浓度比值、认知功能与就业状态之间的关系
Jiaqian Sun,Jie Yin Yee,Yuen Mei See et al.
Jiaqian Sun et al.
Tacrolimus Exposure is Associated with Acute Rejection in the Early Phase After Kidney Transplantation: A Joint Modeling Approach [0.03%]
他克莫司暴露与肾移植术后早期急性排斥反应的关系：联合建模分析
Maaike R Schagen,Alvaro Assis de Souza,Karin Boer et al.
Maaike R Schagen et al.
Background: Reports regarding the relationship between tacrolimus exposure and the risk of acute kidney allograft rejection are conflicting. This may be explained by the previous use of methodological approaches that disr...
Jean-Baptiste Woillard,Marc Labriffe,Pierre Marquet
Jean-Baptiste Woillard
Background: Cyclosporine (CsA), an immunosuppressant widely used in solid-organ transplantation, requires precise therapeutic drug monitoring to balance its efficacy and toxicity. The interdose area under the concentratio...
Efficient Penetration of Terbinafine into Brain Abscesses in a Lung Transplant Recipient with Scedosporiosis: A Short Communication [0.03%]
特比萘芬有效渗透至一例肺移植后须毛孢子菌病患者脑脓肿的病例报道
Keisuke Umemura,Yurie Katsube,Yasuhiro Tsuchido et al.
Keisuke Umemura et al.
Background: Scedosporium spp. typically infect the lungs and can disseminate to various tissues, including the central nervous system (CNS). Voriconazole and terbinafine are both used to treat scedosporiosis. While vorico...
A Real-World Clinical Evaluation of Ganciclovir Exposure and Cytomegalovirus Viremia Outcomes After Adult Kidney Transplantation [0.03%]
一种更佳的临床评估：成人肾脏移植后的甘昔洛韦暴露及巨细胞病毒血症结局
Lukas K van Vugt,Rawan Saleh,Dennis A Hesselink et al.
Lukas K van Vugt et al.
Background: The efficacy and toxicity of valganciclovir prophylaxis are determined by ganciclovir (GCV) exposure. As GCV is predominantly eliminated through glomerular filtration, kidney transplant recipients are at risk ...