Can Piperacillin Dose Be Predicted by Renal Function in Intensive Care Unit Patients? Comparison of 3 Different Formulas [0.03%]
ICU患者肾功能能否预测哌拉西林剂量？三种不同公式比较研究
Sophie Magréault,Takoua Khzouri,Khalil Chaïbi et al.
Sophie Magréault et al.
Background: Although the increased risk of piperacillin underexposure has been previously evidenced in intensive care unit patients with augmented renal clearance, it is still unclear whether the piperacillin dose could b...
Quantification of Vancomycin and Clindamycin in Synovial Tissue and Bone Using Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry [0.03%]
高效液相色谱-串联质谱法测定滑膜组织和骨中的万古霉素和克林霉素浓度
Amanda J Holst,Soma Bahmany,Angela C J van Dorp et al.
Amanda J Holst et al.
Background: Approximately 1-2% of patients undergoing hip or knee arthroplasty encounter a periprosthetic joint infection (PJI). Currently, the treatment involves revision surgeries and long-term antibiotic therapy. Howev...
Population Pharmacokinetic Models of Ampicillin-Sulbactam Among Adult Patients with Infectious Diseases: A Systematic Review [0.03%]
氨苄西林-舒巴坦成人患者感染病人群药代动力学模型的系统评价研究
Mohananasunthari Poornachandran,Sabariah Noor Harun,Teh Sin Yin et al.
Mohananasunthari Poornachandran et al.
Background: Ampicillin-sulbactam is the first-line treatment for pneumonia, aspiration pneumonia, and infections caused by Acinetobacter baumannii. Several population pharmacokinetic (PK) studies have evaluated the intrav...
Alessandra Manca,Andrea Calcagno,Antonio D&#x;Avolio et al.
Alessandra Manca et al.
Background: Tuberculosis (TB) treatment relies on a prolonged first-line antibiotic regimen, including isoniazid, rifampicin (RF), ethambutol (EMB), and pyrazinamide.Pharmacogenetics plays a crucial role in optimizing TB ...
Efficacy of Nalmefene Hydrochloride Injection Combined With Hemoperfusion in the Treatment of Acute Drug Poisoning [0.03%]
盐酸纳美芬联合血液灌流治疗急性药物中毒的疗效分析
Wei Zhou,Xiang Li,Jiamei Jiang et al.
Wei Zhou et al.
Background: This study explored the efficacy of nalmefene hydrochloride injection combined with hemoperfusion in acute drug poisoning treatment. Methods: ...
Therapeutic Drug Monitoring and Pharmacogenomics of Thiopurines in Inflammatory Bowel Disease: International Guidelines Revisited [0.03%]
国际指南再评估：炎症性肠病硫嘌呤药物的治疗药物监测和药物基因组学
Ahmed B Bayoumy,Luc J J Derijks,Nanne K H de Boer
Ahmed B Bayoumy
Background: Thiopurines, including azathioprine, mercaptopurine, and thioguanine (TG), are widely used as maintenance therapies for inflammatory bowel disease (IBD). However, their clinical utility is challenged by interi...
Large-Scale Real-World Monitoring of Mycophenolic Acid Exposure in Liver Transplantation: Impact of Bayesian Dose Adjustment [0.03%]
基于贝叶斯方法调整剂量的肝脏移植患者大规模、真实世界中的霉酚酸暴露监测及影响因素分析
Marc Labriffe,Hamza Sayadi,Jean-Baptiste Woillard et al.
Marc Labriffe et al.
Background: Mycophenolate mofetil is widely used in liver transplantation but poses dosing challenges owing to the narrow therapeutic window and high pharmacokinetic variability of its active moiety, mycophenolic acid (MP...
Shouhua Mu,Xiaojing Zhang,Jingyan Jin et al.
Shouhua Mu et al.
Background: Monoclonal antibody (mAb) drugs have become an important pillar of modern pharmaceutical fields. Owing to their high specificity and affinity, these drugs have shown broad application prospects in various fiel...
Simultaneous Determination of Osimertinib and its Metabolites in Human Plasma for Clinical Applications Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry [0.03%]
用于临床应用的人血浆中奥希替尼及其代谢产物的高效液相色谱-串联质谱法同时测定方法
Jingjing Wu,Liuxian Guo,Guojin Zhou et al.
Jingjing Wu et al.
Background: Osimertinib, the first-line treatment for nonsmall cell lung cancer, has 2 main active metabolites, AZ5104 and AZ7550, which demonstrate potency against wild-type epidermal growth factor receptor mutations. In...
Antibiotic Hypersensitivity: Classification, Mechanisms, Signs, and Diagnostic Approaches: A Critical Review [0.03%]
抗生素过敏：分类、机制、症状和诊断方法批判性 review
Maria Zofia Lisiecka
Maria Zofia Lisiecka
Purpose: This review focuses on antibiotic hypersensitivity, a clinically relevant issue owing to potentially severe adverse reactions. This review describes the classification, mechanisms of occurrence, and clinical mani...