Therapeutic Drug Monitoring of Oral Targeted Anticancer Drugs: Achievements, Experiences, Challenges, and the Path Forward [0.03%]
口服靶向抗癌药物的治疗药物监测：成就、经验、挑战及未来之路
Maud B A van der Kleij,Karolijn W M Groot Beumer,Stijn L W Koolen et al.
Maud B A van der Kleij et al.
Background: The introduction of oral targeted anticancer drugs has revolutionized anticancer treatments. Exposure to these drugs is often affected by individual, disease, or drug characteristics. As a result, these drugs ...
Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges [0.03%]
治疗性药物监测与床旁检测技术：机遇和挑战
Sandro Carrara,Nicolas Widmer,Francesca Rodino et al.
Sandro Carrara et al.
Background: This review re-evaluates therapeutic drug monitoring (TDM) by comparing the current analytical and subsequent clinical interpretation capabilities of hospital or community medical laboratories with the emergin...
Johannes A Kroes,Jeroen Poortvliet,Daan J Touw et al.
Johannes A Kroes et al.
Background: Paracetamol poisoning is one of the most common types of drug-induced poisoning worldwide and can cause severe hepatotoxicity. Acetylcysteine administration is the most effective intervention to prevent hepato...
Simultaneous Quantification of Bictegravir and Emtricitabine Using a Simple and Economical Liquid Chromatography-Ultraviolet Method for Therapeutic Drug Monitoring in Patients with Human Immunodeficiency Virus [0.03%]
一种简单经济的液相色谱-紫外法同时定量比克替拉韦和恩曲他滨用于人类免疫缺陷病毒患者的治疗药物监测方法研究
Haihong Bai,Yuan Fang,Zihe Wang et al.
Haihong Bai et al.
Background: Biktarvy is an effective antiviral drug for patients with HIV. However, owing to its long-term use and poor patient adherence, sustained and effective Biktarvy treatment is consistently limited by insufficient...
Therapeutic Drug Monitoring Versus Fixed-Interval Dosing of Dalbavancin in Implant-Associated Spinal Infections: Grand Round/A Case Study [0.03%]
达巴万星治疗植入物相关的脊柱感染中基于固定时间间隔给药与个体化血药浓度监测的比较：大查房/病例报告研究
Jeroen P A Houwen,Charlotte S Hakkers,Valentijn A Schweitzer et al.
Jeroen P A Houwen et al.
Background: Implant-associated spinal infections (IASI) pose challenges for outpatient management due to the need for frequent intravenous antibiotic administration. Dalbavancin has a prolonged half-life and is a practica...
Comprehensive Review of the Application of Aptamer-Based Point-Of-Care Sensors for Therapeutic Drug Monitoring [0.03%]
基于适配体的点-of-护理传感器在治疗药物监测中的应用全面回顾
Chunjie Shi,Qiaoqiao Li,Tiantian Tang et al.
Chunjie Shi et al.
Background: Therapeutic drug monitoring (TDM) is critical for optimizing drug efficacy and safety in precision medicine; however, conventional TDM methods rely on complex laboratory workflows. Consequently, there is an ur...
Toward Clinical Implementation of a Volumetric Absorptive Microsampling-Based Method for Dasatinib and Imatinib Therapeutic Drug Monitoring [0.03%]
基于体积吸收式微型取样法的达沙替尼和伊马替尼血药浓度监测方法的临床应用研究
Nick Verougstraete,Dominiek Mazure,Christophe P Stove
Nick Verougstraete
Background: Therapeutic drug monitoring (TDM) of tyrosine kinase inhibitors may improve treatment outcomes and individualized therapy in patients with cancer. Compared with plasma, the standard TDM matrix, dried blood mic...
Population Pharmacokinetic Model of Lacosamide in Chinese Children and Adults with Epilepsy [0.03%]
中国癫痫患儿和成人拉考沙胺群体药代动力学模型
Ruoyun Wu,Shanshan Liu,Zhigang Zhao et al.
Ruoyun Wu et al.
Objective: To examine the pharmacokinetics of lacosamide (LCM) in Chinese children and adults with epilepsy and to establish a population pharmacokinetic model. ...
Precision Dosing of Meropenem in a Neonate on CARPEDIEM Dialysis: A Grand Round [0.03%]
CARPEDIEM透析中美罗培南新生儿精准用药的探讨
Ronaldo Morales Junior,Emily Diseroad,Tamara Hutson et al.
Ronaldo Morales Junior et al.
Background: Optimal antibiotic dosing is challenging in critically ill neonates because of the substantial pharmacokinetic variability, which is influenced by factors such as immature renal function, body composition, and...
Priyadarshini Zula,Belmin B J Winston Gysley,Ashish Sharma et al.
Priyadarshini Zula et al.
Background: Fluconazole-tacrolimus interactions occur, but the additional effect of ritonavir is emphasized here, underscoring the need for careful prescription reconciliation in renal transplant recipients living with HI...