Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Analysis of Fluconazole, Isavuconazole, Itraconazole, Hydroxy-Itraconazole, Posaconazole, and Voriconazole in Human Plasma and Serum [0.03%]
一种可靠且易于使用的液相色谱-串联质谱法同时测定人血浆和血清中氟康唑、伊沙康唑、伊曲康唑、奥昔康唑、泊沙康唑及伏立康唑的方法
Carsten Müller,David Gehlen,Cornelia Blaich et al.
Carsten Müller et al.
Background: A fast and easy-to-use liquid chromatography-tandem mass spectrometry method for the determination and quantification of 6 triazoles [fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itracon...
Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment [0.03%]
CYP2B6基因型及其他候选基因在维持剂量海洛因成瘾者美沙酮稳态血药浓度的联合效应分析
Marianne K Kringen,Fatemeh Chalabianloo,Jean-Paul Bernard et al.
Marianne K Kringen et al.
Background: A considerable interindividual variability in methadone pharmacokinetics is seen in patients on methadone maintenance treatment. The aim of this study was to clarify the impact of the reduced function CYP2B6*6...
Therapeutic Drug Monitoring for Perampanel in Japanese Epilepsy Patients: Influence of Concomitant Antiepileptic Drugs [0.03%]
日本癫痫患者使用Perampanel药物治疗中的药代动力学监测：合并使用的抗癫痫药物的影响
Yoshiaki Yamamoto,Naotaka Usui,Takuji Nishida et al.
Yoshiaki Yamamoto et al.
Background: Perampanel is a new antiepileptic drug (AED) that acts as a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist and is mainly metabolized by cytochrome P450 (CYP) 3...
Pharmacokinetics of Antibiotics in Sub-Saharan African Patient Populations: A Systematic Review [0.03%]
抗生素在撒哈拉以南非洲患者人群中的药代动力学：系统评价
Jeannet C Bos,Reinier M van Hest,Jan M Prins
Jeannet C Bos
Background: In sub-Saharan Africa (SSA), severe febrile illness accounts for a large majority of medical admissions. SSA patients may also suffer from cachexia and organ dysfunction resulting from tuberculosis, hepatitis ...
Current Practices for Therapeutic Drug Monitoring of Biopharmaceuticals in Pediatrics [0.03%]
儿科生物制药治疗药物监测的现行实践
Sara Murias,Lorena Magallares,Fatima Albizuri et al.
Sara Murias et al.
Biopharmaceuticals have recently emerged as effective treatments for refractory pediatric autoimmune conditions. Several reports have shown a relationship between drug concentration, antidrug antibodies, and clinical response in these patie...
Therapeutic Drug Monitoring of Biopharmaceuticals May Benefit From Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Modeling [0.03%]
生物药物的治疗药物监测可能受益于药代动力学和药代动力学-药效学建模
Christophe Passot,Mieke F Pouw,Denis Mulleman et al.
Christophe Passot et al.
Biopharmaceuticals, especially monoclonal antibodies, have been increasingly used to treat several chronic inflammatory diseases. Due to the complexity of their pharmacokinetics and concentration-effect relationship, therapeutic drug monito...
Challenges for Detecting Valproic Acid in a Nontargeted Urine Drug Screening Method [0.03%]
非目标尿药筛查法中检测丙戊酸钠的挑战性问题研究
Jeffrey D Pope,Marion J Black,Olaf H Drummer et al.
Jeffrey D Pope et al.
Background: Valproic acid (VPA) is a widely prescribed medicine, and acute toxicity is possible. As such, it should be included in any nontargeted urine drug screening method. In many published liquid chromatography-elect...
Dried Blood Spots Combined With Ultra-High-Performance Liquid Chromatography-Mass Spectrometry for the Quantification of the Antipsychotics Risperidone, Aripiprazole, Pipamperone, and Their Major Metabolites [0.03%]
结合超高效液相色谱质谱法测定抗精神病药利培酮、阿立哌唑、匹莫perphenazine胺及其主要代谢产物的干血斑方法
Camille Tron,Sanne M Kloosterboer,Bart C H van der Nagel et al.
Camille Tron et al.
Background: Risperidone, aripiprazole, and pipamperone are antipsychotic drugs frequently prescribed for the treatment of comorbid behavioral problems in children with autism spectrum disorders. Therapeutic drug monitorin...
Dried Blood Spot Sampling for Tacrolimus and Mycophenolic Acid in Children: Analytical and Clinical Validation [0.03%]
儿童Tacrolimus和Mycophenolic酸干血斑采样分析及临床验证
Lisa C Martial,Karin E J Hoogtanders,Michiel F Schreuder et al.
Lisa C Martial et al.
Background: Tacrolimus and mycophenolic acid (MPA) are the backbone of immunosuppressive therapy after pediatric kidney transplantation. Dosing of these drugs is individualized by therapeutic drug monitoring. Dried blood ...
Effect of CYP3A4 and CYP3A5 Genetic Polymorphisms on the Pharmacokinetics of Sirolimus in Healthy Chinese Volunteers [0.03%]
CYP3A4和CYP3A5基因多态性对中国健康志愿者他克莫司药代动力学的影响研究
Jing Zhang,Ying Dai,Zhihong Liu et al.
Jing Zhang et al.
Background: Sirolimus is a promising immunosuppressive drug for preventing the rejection of organ transplants. However, inter-individual variability in sirolimus pharmacokinetics causes adverse drug reactions, compromisin...