Clinical Application of Volumetric Absorptive Microsampling for Therapeutic Drug Monitoring of Oral Targeted Anticancer Drugs [0.03%]
体积吸收微采样在口服靶向抗癌药物治疗药物监测中的临床应用
Marinda Meertens,Nikki Kerssemakers,Niels de Vries et al.
Marinda Meertens et al.
Background: Therapeutic Drug Monitoring optimizes oral anticancer drug treatment by measuring plasma levels. Volumetric absorptive microsampling (VAMS) allows home sampling with a minimal blood sample. However, methods fo...
Alexandr Gish,Apolline Saint Omer,Juliette Faillie et al.
Alexandr Gish et al.
Olanzapine; Postinjection Syndrome; Pharmacokinetics in View: Grand Round/A Case Study [0.03%]
奥氮胺；注射后综合症；药代动力学分析：大圆图/病例研究
Johanne Rozema,Cornelis Paul van Stee,Daniel J Touw et al.
Johanne Rozema et al.
Olanzapine is a second-generation antipsychotic that is frequently administered intramuscularly as a slow-release depot and maintenance treatment for schizophrenia. Therapeutic values range from 20 to 80 mcg/L and levels >100 mcg/L are cons...
Predictive Performance of Bayesian Dosing Software for Vancomycin in Intensive Care Unit Patients [0.03%]
贝叶斯给药软件对重症监护病房患者使用万古霉素的预测效果研究
Gali Bai,Hui Qi,Yaqun Huang et al.
Gali Bai et al.
Background: According to the updated guidelines, Bayesian-derived area under the curve estimation is recommended to guide vancomycin dosing. However, the Bayesian dosing software that facilitates this procedure has not be...
Examining Different Methods to Assess Busulfan Exposure in Pediatric Hematopoietic Stem Cell Transplant Recipients [0.03%]
评估布西耐在儿科血液干细胞移植接受者中不同暴露评估方法的效果
Maxwell Thompson,Christine E Staatz,Christopher J Fraser et al.
Maxwell Thompson et al.
Background: Noncompartmental analysis (NCA) and model-based method (MBM) can be used to estimate the cumulative area under the concentration-time curve (AUCcum) during therapeutic drug monitoring. Understanding predictive...
A Sensitive Ultrafiltration Plus RP-HPLC-FLD Method to Quantify Total and Free Perampanel Concentrations in the Plasma of Patients With Epilepsy: A Fully Validated Assay With Clinical Application [0.03%]
用于量化癫痫患者血浆中佩利文总浓度和游离浓度的超滤结合RP-HPLC-FLD法：一个完全验证并具有临床应用价值的方法
Zhonghua Dong,Peng Wang,Xueyan Cui et al.
Zhonghua Dong et al.
Background: Perampanel (PER), a novel antiepileptic drug, exhibits high protein binding. Given the drug's susceptibility to various factors, including drug interactions, and the considerable variability in blood concentra...
How to Determine a Therapeutic Reference Range for a Psychotropic Drug Systematically? Recommendations of the TDM Task Force of the AGNP [0.03%]
如何系统地确定一种精神药物的治疗参考范围？AGNP治疗药物监测任务组的建议
Xenia M Hart,Friederike Amann,Pierre Baumann et al.
Xenia M Hart et al.
Background: Therapeutic drug monitoring (TDM) is essential for controlling pharmacogenetic and pharmacokinetic variations and for optimizing pharmacotherapy. However, its value is often underestimated because of nonsystem...
Xiaoshuang He,Yongjie Ding,Jie Fang et al.
Xiaoshuang He et al.
Background: A patient was treated with abemaciclib and rivaroxaban. Therapeutic drug monitoring revealed high total plasma concentrations of rivaroxaban, which was identified as likely cause of abnormal bleeding. This res...
External Evaluation of Longitudinal Population Pharmacokinetic Models of Vancomycin in Patients With Osteoarticular Infections [0.03%]
万古霉素治疗骨关节感染的纵向群体药代动力学模型外部评价研究
Van Dong Nguyen,Alice Côté,Amélie Marsot
Van Dong Nguyen
Background: Osteoarticular infections pose a challenge for therapeutic drug monitoring of vancomycin because they often require prolonged treatment. Given the extensive renal elimination of vancomycin, its pharmacokinetic...
Development of a UHPLC-MS/MS Method for the Determination of Omadacycline in Human Plasma [0.03%]
一种用于测定人血浆中奥马达昔利的方法的开发：高效液相色谱-质谱法
Chuang Chen,Yao-Jie Chen,Jing Fu et al.
Chuang Chen et al.
Omadacycline is a novel aminomethylcycline antibiotic that retains its antibacterial activity against strain-specific efflux pumps and ribosomal protective protein mechanisms of tetracycline resistance. To determine the concentration of oma...