Alec Rutherford,Trinh Bui,Jaya Gupta et al.
Alec Rutherford et al.
Proportionate palliative sedation (PPS) is an important therapeutic option for patients at the end of life who experience intractable suffering despite use of all conventional interventions. Clinical guidelines for PPS differ between instit...
The Risk of Chronic Opioid Utilization with Tramadol: A Narrative Review of the Literature [0.03%]
曲马多利用的风险：文献叙述性回顾
Eric P Borrelli
Eric P Borrelli
Tramadol is a prescription opioid analgesic which was first approved in the U.S. in 1995. Tramadol was not a controlled substance on the federal level until August 2014 when it was classified as a Schedule-IV controlled substance. Even with...
Administration of Intrathecal Ketamine in the Treatment of Refractory Cancer Pain: A Case Series [0.03%]
氯胺酮脊髓给药治疗难治性癌痛的疗效观察：病例系列研究
Laura Hanssen Textor,William S Rosenberg
Laura Hanssen Textor
Objectives: Intrathecal opioids may not be effective for severe refractory pain associated with cancer. Intrathecal ketamine may be effective in reducing pain in these cases, however, there is legitimate concern regarding...
Characteristics and Economic Outcomes of Treated and Untreated Patients Diagnosed with Opioid Use Disorder [0.03%]
阿片类药物使用障碍患者的特征和经济结果
Howard Weston Schmutz,Connor Willis,Emeka Elvis Duru et al.
Howard Weston Schmutz et al.
Opioid Use Disorder (OUD) imposes significant burdens on healthcare systems, leading to increased costs and utilization. Limited real-world data exist on the healthcare resource use, charges, and impact of medications for OUD (MOUD). This s...
Safety and Efficacy of Dexmedetomidine in Spinal Fusion: A Systematic Review and Meta-Analysis Dexmedetomidine in Spinal Fusion Surgery [0.03%]
丁丙诺啡在脊柱融合手术中的安全性和有效性：系统回顾和荟萃分析
María Jesús Rodríguez,Alfonso Vázquez,Víctor Rodriguez-Domínguez et al.
María Jesús Rodríguez et al.
Dexmedetomidine (DEX) has been proposed as an opioid-sparing adjunct after spinal fusion, but its efficacy across age groups is unclear. We conducted a systematic review and meta-analysis following PRISMA and registered in International Pro...
Patient-Reported Paresthesia After Administration of Suzetrigine: A Case Report [0.03%]
右美沙芬致患者皮肤异感症一例报告
Daniel Adams,Mary Bailey
Daniel Adams
Suzetrigine is a novel non-opioid analgesic for treating moderate to severe acute pain. Clinical trials for postoperative pain demonstrated that the most common side effects were headache and constipation. Since it became commercially avail...
A Stepwise Approach to Transitioning from Methadone to Buprenorphine for Cancer-Related Pain in an Outpatient Setting: A Novel Opioid Rotation Without Clinically Evident Withdrawal Symptoms [0.03%]
门诊甲氧纳转丁丙诺啡治疗癌痛的分步方案：一种无需经历明显戒断症状的阿片类药物转换新方法
Sushma Shivananda,Pushpa V H,Tayyaba Irshad
Sushma Shivananda
This case report details a successful transition of a patient with cancer-related pain from long-term methadone therapy to sublingual buprenorphine using a micro-induction protocol in an outpatient setting. The transition involved initiatin...
A Pharmacist's Guide to Managing Difficult Conversations in Pain Management and Opioid Use Settings [0.03%]
药房从业人员眼中的疼痛管理和阿片类药物使用环境中困难对话处理指南
Denise Courtney,Sudheer Potru,Sing Ping Chow et al.
Denise Courtney et al.
Pain remains one of the most common reasons that individuals seek healthcare. Despite advances in pain care and an improved understanding of the harms associated with opioid use, there is still considerable reliance on opioid medications fo...
Medication Overuse Headache in the US: A National Cross-Sectional Survey [0.03%]
美国的药物过度使用性头痛：一项全国横向调查研究
Naomi N Bailey,Christopher M Herndon,Timothy D Cruz
Naomi N Bailey
This study was conducted to assess participant understanding of medication-overuse headache (MOH) by adults in the US. It was conducted using an 18 item, descriptive questionnaire which addressed demographic information, frequency and sever...
Post-Operative Bleed Risks Associated with Perioperative Nonsteroidal Anti-Inflammatory Drugs: A Narrative Review [0.03%]
围手术期使用非甾体抗炎药物与术后出血风险相关性：综述文章
Laura L Seitz,Sanny Juresic,Leslie R Siegel et al.
Laura L Seitz et al.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications that function by inhibiting cyclooxygenase enzymes. Although they are highly effective in managing pain and inflammation, their potential for increasing bleeding risk...