Molecular imaging of cathepsin B proteolytic enzyme activity reflects the inflammatory component of atherosclerotic pathology and can quantitatively demonstrate the antiatherosclerotic therapeutic effects of atorvastatin and glucosamine [0.03%]
猫粮组织蛋白酶B蛋白水解酶活性分子影像反映动脉粥样硬化炎性成分并可定量显示阿托伐他汀和葡萄糖胺抗动脉粥样硬化治疗效应
Dong-Eog Kim,Jeong-Yeon Kim,Dawid Schellingerhout et al.
Dong-Eog Kim et al.
Inflammation in atherosclerotic plaques causes plaque vulnerability and rupture, leading to thromboembolic complications. Cathepsin B (CatB) proteases secreted by macrophages play a major role in plaque inflammation. We used a CatB-activata...
Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models [0.03%]
活细胞和动物模型中NF-κB活性的实时监测技术
Christian E Badr,Johanna M Niers,Lee-Ann Tjon-Kon-Fat et al.
Christian E Badr et al.
Nuclear factor kappaB (NF-kappaB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. We designed a reporter system based on NF-kappaB responsive promoter elements driving express...
Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer [0.03%]
一种新型增强感染性的溶瘤腺病毒：衣壳整合型双模态成像腺病毒用于卵巢癌监测治疗效果
Kristopher J Kimball,Angel A Rivera,Kurt R Zinn et al.
Kristopher J Kimball et al.
We sought to develop a cancer-targeted, infectivity-enhanced oncolytic adenovirus that embodies a capsid-labeling fusion for noninvasive dual-modality imaging of ovarian cancer virotherapy. A functional fusion protein composed of fluorescen...
Rohan Dharmakumar,Zhouli Zhang,Ioannis Koktzoglou et al.
Rohan Dharmakumar et al.
Negative contrast magnetic resonance imaging (MRI) methods using magnetic susceptibility shifting agents have become one of the most important approaches in cellular imaging research. However, visualizing and tracking labeled cells on the b...
Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy [0.03%]
脑肿瘤生长的测量方法：生物发光成像与磁共振成像联合策略
Sarah C Jost,Lynne Collins,Sarah Travers et al.
Sarah C Jost et al.
Small-animal tumor models are essential for developing translational therapeutic strategies in oncology research, with imaging having an increasingly important role. Magnetic resonance imaging (MRI) offers tumor localization, volumetric mea...