Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionucleoside probes [0.03%]
建立的放射性核素探针成像HSV1-tk表达降低肠道背景放射活性的不同策略
Alessandro Ruggiero,Peter Brader,Inna Serganova et al.
Alessandro Ruggiero et al.
One limitation of HSV1-tk reporter positron emission tomography (PET) with nucleoside analogues is the high background radioactivity in the intestine. We hypothesized that endogenous expression of thymidine kinase in bacterial flora could p...
Patient-tailored, imaging-guided, long-term temozolomide chemotherapy in patients with glioblastoma [0.03%]
个体化、影像指导下的胶质母细胞瘤患者长期替莫唑胺化疗
Norbert Galldiks,Lutz W Kracht,Lothar Burghaus et al.
Norbert Galldiks et al.
We present two patients with glioblastoma with an unusually stable clinical course and long-term survival who were treated after surgery and radiotherapy with adjuvant temozolomide (TMZ) chemotherapy for 17 and 20 cycles, respectively. Afte...
Case Reports
Molecular imaging. 2010 Feb;9(1):40-6. DOI: 2010
Quantitative assessment of intestinal injury using a novel in vivo, near-infrared imaging technique [0.03%]
一种新型肠道损伤量化评价的近红外在体影像技术
Todd W Costantini,Brian P Eliceiri,Carrie Y Peterson et al.
Todd W Costantini et al.
Intestinal injury owing to inflammation, severe trauma, and burn is a leading cause of morbidity and mortality. Currently, animal models employed to study the intestinal response to injury and inflammation depend on outdated methods of anal...
Optical imaging of integrin alphavbeta3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers [0.03%]
带有四乙二醇连接臂的近红外荧光双RGD配体成像整合素αvβ3表达
Zhaofei Liu,Shuanglong Liu,Gang Niu et al.
Zhaofei Liu et al.
Integrin alphavbeta3 plays great roles in tumor angiogenesis, invasion, and metastasis. We report here the noninvasive visualization of tumor integrin alphavbeta3 expression by using near-infrared fluorescence (NIRF) imaging of an IRDye800-...
Jason P Holland,Matthew J Williamson,Jason S Lewis
Jason P Holland
Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy of disease has been the driving force behind burgeoning research interests in the design of novel radiopharmaceuticals. Until recently, the majority o...
Review
Molecular imaging. 2010 Feb;9(1):1-20. DOI: 2010
Toxicity of organic fluorophores used in molecular imaging: literature review [0.03%]
有机分子影像荧光探针的毒性：文献综述
Raphael Alford,Haley M Simpson,Josh Duberman et al.
Raphael Alford et al.
Fluorophores are potentially useful for in vivo cancer diagnosis. Using relatively inexpensive and portable equipment, optical imaging with fluorophores permits real-time detection of cancer. However, fluorophores can be toxic and must be i...
Review
Molecular imaging. 2009 Dec;8(6):341-54. DOI: 2009
Extra domain B fibronectin as a target for near-infrared fluorescence imaging of rheumatoid arthritis affected joints in vivo [0.03%]
靶向额外结构B型纤连蛋白的近红外荧光成像小鼠类风湿关节炎关节炎症反应
Sonja Vollmer,Axel Vater,Kai Licha et al.
Sonja Vollmer et al.
Abstract We investigated a molecular imaging approach for the detection of collagen-induced arthritis in rats by targeting the extra domain B (ED-B) of the extracellular matrix protein fibronectin. ED-B is a highly conserved domain (identic...
Fluorescence imaging of fast retrograde axonal transport in living animals [0.03%]
活体动物快速逆行轴突运输的荧光成像技术
Dawid Schellingerhout,Lucia G Le Roux,Sebastian Bredow et al.
Dawid Schellingerhout et al.
Our purpose was to enable an in vivo imaging technology that can assess the anatomy and function of peripheral nerve tissue (neurography). To do this, we designed and tested a fluorescently labeled molecular probe based on the nontoxic C fr...
Prasun J Mishra,Lata G Menon,Pravin J Mishra et al.
Prasun J Mishra et al.
Bicistronic vectors are useful tools for exogenous expression of two gene products from a single promoter element; however, reduced expression of protein from the second cistron compared with the first cistron is a common limitation to this...
John V Frangioni
John V Frangioni