Tumor delivery of ultrasound contrast agents using Shiga toxin B subunit [0.03%]
利用舒加毒素B亚基输送超声造影剂至肿瘤中
Olivier Couture,Estelle Dransart,Sabrina Dehay et al.
Olivier Couture et al.
The present study demonstrates the targeting of ultrasound contrast agents to human xenograft tumors by exploiting the overexpression of the glycolipid Gb3 in neovasculature. To this end, microbubbles were functionalized with a natural Gb3 ...
General approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles [0.03%]
综合分析公共基因组谱以识别癌症影像潜在靶点的通用方法论研究
Yongliang Yang,S James Adelstein,Amin I Kassis
Yongliang Yang
Molecular imaging has moved to the forefront of drug development and biomedical research. The identification of appropriate imaging targets has become the touchstone for the accurate diagnosis and prognosis of human cancer. Particularly, ce...
Yoon-Young Jang,Zhaohui Ye,Linzhao Cheng
Yoon-Young Jang
During the last decade, there has been enormous progress in understanding both multipotent stem cells such as hematopoietic stem cells and pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells. However, it h...
Review
Molecular imaging. 2011 Apr;10(2):111-22. DOI: 2011
Pulsed magneto-motive ultrasound imaging using ultrasmall magnetic nanoprobes [0.03%]
基于极小磁性纳米探针的脉冲磁场声学成像技术
Mohammad Mehrmohammadi,Junghwan Oh,Srivalleesha Mallidi et al.
Mohammad Mehrmohammadi et al.
Nano-sized particles are widely regarded as a tool to study biologic events at the cellular and molecular levels. However, only some imaging modalities can visualize interaction between nanoparticles and living cells. We present a new techn...
Summer L Gibbs-Strauss,Khaled A Nasr,Kenneth M Fish et al.
Summer L Gibbs-Strauss et al.
Nerve damage is the major morbidity of many surgeries, resulting in chronic pain, loss of function, or both. The sparing of nerves during surgical procedures is a vexing problem because surrounding tissue often obscures them. To date, syste...
Detection of leukotriene receptor CysLT1R in inflammatory diseases by molecular imaging with near-infrared fluorescence-based contrast agents [0.03%]
基于近红外荧光的对比剂在炎症疾病中检测白三烯受体CysLT1R的分子影像学研究
Corinna Busch,Marta Passon,Matthias Wenzel et al.
Corinna Busch et al.
As leukotriene D4 receptor CysLT1R upregulation is an early event in inflammatory processes, specific detection of CysLT1R via molecular imaging might be a promising diagnostic tool for inflammatory diseases. We coupled a specific anti-CysL...
John V Frangioni
John V Frangioni
Glypican-3 targeting of liver cancer cells using multifunctional nanoparticles [0.03%]
利用多功能纳米粒子靶向肝癌细胞中的Glypican-3蛋白质
James O Park,Zachary Stephen,Conroy Sun et al.
James O Park et al.
Imaging is essential in accurately detecting, staging, and treating primary liver cancer (hepatocellular carcinoma [HCC]), one of the most prevalent and lethal malignancies. We developed a novel multifunctional nanoparticle (NP) specificall...
Near-infrared imaging method for the in vivo assessment of the biodistribution of nanoporous silicon particles [0.03%]
体内近红外成像法评估纳米多孔硅颗粒生物分布的方法
Ennio Tasciotti,Biana Godin,Jonathan O Martinez et al.
Ennio Tasciotti et al.
In the development of new nanoparticle-based technologies for therapeutic and diagnostic purposes, understanding the fate of nanoparticles in the body is crucial. We recently developed a multistage vector delivery system comprising biodegra...
Proteomic analysis of serum opsonins impacting biodistribution and cellular association of porous silicon microparticles [0.03%]
影响多孔硅微粒体内分布和细胞摄取的血清调理素蛋白组学分析
Rita E Serda,Elvin Blanco,Aaron Mack et al.
Rita E Serda et al.
Mass transport of drug delivery vehicles is guided by particle properties, such as size, shape, composition, and surface chemistry, as well as biomolecules and serum proteins that adsorb to the particle surface. In an attempt to identify se...