Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results [0.03%]
一种实时改进血管内分子成像和指导药物输送的新技术：体外及离体结果
Abhay V Patil,Joshua J Rychak,Alexander L Klibanov et al.
Abhay V Patil et al.
Ultrasound-based molecular imaging employs targeted microbubbles to image vascular pathology. This approach also has the potential to monitor molecularly targeted microbubble-based drug delivery. We present an image-guided drug delivery tec...
Christel Vangestel,Marc Peeters,Gilles Mees et al.
Christel Vangestel et al.
In this review, data on noninvasive imaging of apoptosis in oncology are reviewed. Imaging data available are presented in order of occurrence in time of enzymatic and morphologic events occurring during apoptosis. Available studies suggest...
Gaussia luciferase for bioluminescence tumor monitoring in comparison with firefly luciferase [0.03%]
与萤火虫荧光素酶相比，使用Gaussia荧光素酶进行生物发光肿瘤监测
Yusuke Inoue,Fugeng Sheng,Shigeru Kiryu et al.
Yusuke Inoue et al.
Gaussia luciferase (Gluc) is a secreted reporter, and its expression in living animals can be assessed by in vivo bioluminescence imaging (BLI) or blood assays. We characterized Gluc as an in vivo reporter in comparison with firefly lucifer...
Comparative Study
Molecular imaging. 2011 Oct;10(5):377-85. DOI:10.2310/7290.2010.00057 2011
Increased breast density correlates with the proliferation-seeking radiotracer (99m)Tc(V)-DMSA uptake in florid epithelial hyperplasia and in mixed ductal carcinoma in situ with invasive ductal carcinoma but not in pure invasive ductal carcinoma or in mild epithelial hyperplasia [0.03%]
乳腺密度增大与增生性上皮细胞病变和导管内癌伴有侵袭性导管原位癌中放射示踪剂(Tc)V-DMSA的摄取有关，但与单纯浸润性导管癌或轻度上皮增生无关
Vassilios Papantoniou,Pipitsa Valsamaki,Evangelia Sotiropoulou et al.
Vassilios Papantoniou et al.
The purpose of this study was to assess the relationship of mammographic breast density (BD) and cell proliferation/focal adhesion kinase activation-seeking radiotracer technetium 99m pentavalent dimercaptosuccinic acid (99mTc(V)-DMSA) upta...
Multimodality imaging of endothelial progenitor cells with a novel multifunctional probe featuring positive magnetic resonance contrast and near-infrared fluorescence [0.03%]
一种新型多功能探针标记内皮祖细胞的多模态成像研究——兼具有正性磁共振对比与近红外荧光功能
Shenghong Ju,Yiru Qiu,Cong Li et al.
Shenghong Ju et al.
The multimodal strategy incorporating T1-weighted magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescence imaging can complement their strengths to provide images with high sensitivity and spatial resolution for noninvasively ...
Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in the APC(Min/+) mouse using optical colonography [0.03%]
光学结肠镜引导下的Rh-I-UEA-1交联脂质体对APC(Min/+)鼠腺瘤性息肉靶向示踪作用研究
Celeste A Roney,Biying Xu,Jianwu Xie et al.
Celeste A Roney et al.
Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (...
DNA nanoparticles: detection of long-term transgene activity in brain using bioluminescence imaging [0.03%]
用于脑内长期基因表达的生物发光成像检测纳米载体脱逸程度研究
David M Yurek,Anita M Fletcher,Matthew McShane et al.
David M Yurek et al.
In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer l...
Comparison of rNIS and hNIS as reporter genes for noninvasive imaging of bone mesenchymal stem cells transplanted into infarcted rat myocardium [0.03%]
比较rNIS和hNIS作为 reporters基因在非侵入性成像中的作用：观察移植至梗死大鼠心肌内的骨髓间质干细胞
Shuo Hu,Wei Cao,Xiaoli Lan et al.
Shuo Hu et al.
The purpose of this study was to investigate and compare the feasibility of rat sodium iodide symporter (rNIS) and human sodium iodide symporter (hNIS) as reporter genes for noninvasive monitoring of rat bone marrow mesenchymal stem cells (...
High-resolution computed tomography of single breast cancer microcalcifications in vivo [0.03%]
活体乳腺癌钙化灶的高分辨率CT研究
Kazumasa Inoue,Fangbing Liu,Jack Hoppin et al.
Kazumasa Inoue et al.
Microcalcification is a hallmark of breast cancer and a key diagnostic feature for mammography. We recently described the first robust animal model of breast cancer microcalcification. In this study, we hypothesized that high-resolution com...
Dual-modality monitoring of tumor response to cyclophosphamide therapy in mice with bioluminescence imaging and small-animal positron emission tomography [0.03%]
用于监测小鼠环磷酰胺治疗肿瘤响应的双模式生物发光成像和小动物正电子发射断层扫描研究
Xibo Ma,Zhaofei Liu,Xin Yang et al.
Xibo Ma et al.
The purpose of this study was to noninvasively monitor the therapeutic efficacy of cyclophosphamide (CTX) in a mouse model by dual-modality molecular imaging: positron emission tomography (PET) and bioluminescence imaging (BLI). Firefly luc...