Comparison of computed tomography- and optical image-based assessment of liposome distribution [0.03%]
基于CT和光学图像的脂质体分布评价方法比较
Huang Huang,Michael Dunne,John Lo et al.
Huang Huang et al.
The use of multimodal imaging as a tool to assess the in vivo pharmacokinetics and biodistribution of nanocarriers is important in understanding the nature of their in vivo transport. The current study reports the development of a nano-size...
[18F]fluoroethyltyrosine-positron emission tomography-based therapy monitoring after stereotactic iodine-125 brachytherapy in patients with recurrent high-grade glioma [0.03%]
18F标记氟乙基酪氨酸正电子发射断层扫描在立体定向碘125永久植入术治疗复发性高级别胶质瘤术后疗效监测中的应用价值研究
Nathalie L Jansen,Bogdana Suchorska,Silke B Schwarz et al.
Nathalie L Jansen et al.
Therapy monitoring of glioma after stereotactic iodine-125 brachytherapy (SBT) remains challenging because posttherapeutic changes in magnetic resonance imaging can mimic tumor progression. We evaluated the prognostic value of serial [18F]f...
Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography [0.03%]
靶向肿瘤血管生成的诊疗共聚物聚（HPMA）-c（RGDyK）-DOTA-64Cu的合成与表征：正电子发射断层扫描可视化定位肿瘤
Jianchao Yuan,Haiyuan Zhang,Harpreet Kaur et al.
Jianchao Yuan et al.
Poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymers were synthesized and characterized for tumor localization in vivo as a theranostic scaffold for cancer imaging and anticancer drug delivery targeting tumor angiogenesis. Tumor localization of the pol...
Imaging of firefly luciferase activity under antiangiogenic therapy in a heat shock protein 70-transfected melanoma tumor model [0.03%]
热休克蛋白70转染的黑色素瘤肿瘤模型中抗新生血管生成疗法下的荧光素酶活性成像
Walter Hundt,Christian Schink,Silke Steinbach et al.
Walter Hundt et al.
We investigated the effect of targeted gene therapy on heat shock protein 70 (Hsp70) expression in a melanoma tumor model (M21). M21 cells transfected with a plasmid containing the firefly luciferase reporter gene (ffluc), whose expression ...
Efficient 18F labeling of cysteine-containing peptides and proteins using tetrazine-trans-cyclooctene ligation [0.03%]
用于含半胱氨酸肽和蛋白质的高效18F标记的四嗪-反式环辛烯连接法
Shuanglong Liu,Matthew Hassink,Ramajeyam Selvaraj et al.
Shuanglong Liu et al.
18F positron emission tomography (PET) has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a short half-life of ≈ 110 minutes. However, the short h...
Detection of Fas-associated death domain and its variants' self-association by fluorescence resonance energy transfer in living cells [0.03%]
利用荧光共振能量转移技术检测Fas相关死亡结构域及其突变体在活细胞内的寡聚化现象
Sheng Wang,Yuan Chen,Qiong Wu et al.
Sheng Wang et al.
Fas-associated death domain (FADD) is an adaptor molecule for the death receptor subfamily of the tumor necrosis factor receptor superfamily, but it is also required for cell proliferation. FADD protein has the potential to highly oligomeri...
Interaction of magnetically labeled multipotent mesenchymal stromal cells and E-and P-selectins monitored by magnetic resonance imaging in mice [0.03%]
磁性标记的多能间质干细胞与E和P-选择素在小鼠体内相互作用的磁共振成像监测
Kersten Peldschus,Johannes Salamon,Daniel Wicklein et al.
Kersten Peldschus et al.
The purpose of this study was to analyze the influence of E- and P-selectins on the migratory pattern of magnetically labeled multipotent mesenchymal stromal cells (MSCs) in mice using magnetic resonance imaging (MRI). Murine MSCs were labe...
Alexander Zarkov,Aleksey Vasilev,Todor Deligeorgiev et al.
Alexander Zarkov et al.
To answer the demands of scientific and medical imaging issues, the family of nucleic acid fluorescent dyes is constantly enlarging. Most of the developed dyes reveal high qualities in bulk solution assays but are inefficient to produce a s...
Imaging of magnetic microfield distortions allows sensitive single-cell detection [0.03%]
磁微场畸变成像可实现敏感的单细胞检测
Randall L Lindquist,Sebastian Papazoglou,Constantin Scharlach et al.
Randall L Lindquist et al.
Cell tracking with magnetic resonance imaging (MRI) is mostly performed using superparamagnetic iron oxide (SPIO) nanoparticle-labeled cells. However, negative contrast in T2*-weighted imaging is inherently problematic as a homogeneous back...
Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm [0.03%]
[碳-11]-（+）丙基己氢萘氧化锌正电子发射断层显像剂静脉团注联合恒速输注下的重测信度研究
Dianne E Lee,Jean-Dominique Gallezot,Ming-Qiang Zheng et al.
Dianne E Lee et al.
We examined the reproducibility of using the constant infusion paradigm for equilibrium measurement of D2/3 receptors using [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO) positron emission tomography (PET). Six subjects were scanned with ...