The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model [0.03%]
生理学和方法学因素对18F-FDG小鼠脑显像影响的阿尔茨海默病双转基因模型示例研究
Steven Deleye,Ann-Marie Waldron,Jill C Richardson et al.
Steven Deleye et al.
Introduction: In this study, the influence of physiological determinants on 18F-fluoro-d-glucose ((18)F-FDG) brain uptake was evaluated in a mouse model of Alzheimer disease. ...
Monitoring Apoptosis of Breast Cancer Xenograft After Paclitaxel Treatment With 99mTc-Labeled Duramycin SPECT/CT [0.03%]
用SPECT/CT监测99mTc-Duramycin显像小鼠乳腺癌移植瘤细胞在紫杉醇处理后的凋亡状况
Rui Luo,Lei Niu,Fan Qiu et al.
Rui Luo et al.
Our goal was to validate the feasibility of(99m)Tc-duramycin as a potential apoptosis probe for monitoring tumor response to paclitaxel in breast cancer xenografts. The binding of(99m)Tc-duramycin to phosphatidylethanolamine was validated i...
Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model [0.03%]
针对整合素α6β4的免疫靶向用于胰腺癌模型的一氧化氮发射计算机断层扫描及近红外荧光成像
Winn Aung,Atsushi B Tsuji,Hitomi Sudo et al.
Winn Aung et al.
To explore suitable imaging probes for early and specific detection of pancreatic cancer, we demonstrated that α6β4integrin is a good target and employed single-photon emission computed tomography (SPECT) or near-infrared (NIR) imaging fo...
Daniel Spira,Rüdiger Bantleon,Hartwig Wolburg et al.
Daniel Spira et al.
Objectives: To use the superparamagnetic iron oxide (SPIO) contrast agent Resovist (±transfection agent) to label human melanoma cells and determine its effects on cellular viability, microstructure, iron quantity, and m...
The Drug Excipient Cyclodextrin Interacts With d-Luciferin and Interferes With Bioluminescence Imaging [0.03%]
药物辅料环糊精与d-鲁Luciferin相互作用并干扰生物发光成像
Jeyan S Kumar,Lisa M Miller Jenkins,Michael M Gottesman et al.
Jeyan S Kumar et al.
Cyclodextrins are well-characterized, barrel-shaped molecules that can solubilize organic small molecules in aqueous solution via host-guest interactions. As such, cyclodextrins are used as excipients for experimental therapeutics in vivo. ...
Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807 [0.03%]
新型Tau-PET示踪剂与[18F]T808和[18F]T807的比较研究
Lieven Declercq,Sofie Celen,Joan Lecina et al.
Lieven Declercq et al.
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acqui...
Comparative Study
Molecular imaging. 2016 Jan 27:15:1536012115624920. DOI:10.1177/1536012115624920 2016
Pei Yuin Keng,R Michael van Dam
Pei Yuin Keng
The emerging technology of digital microfluidics is opening up the possibility of performing radiochemistry at the microliter scale to produce tracers for positron emission tomography (PET) labeled with fluorine-18 or other isotopes. Workin...
Biometabolic Distribution of 99mTc-3PRGD2 and Its Potential Value in Monitoring Chemotherapeutic Effects [0.03%]
99mTc-3PRGD2的生物代谢分布及监测化疗效果的潜在价值研究
Jian-Guo Wu,Shao-Li Song,Xiang Zhou et al.
Jian-Guo Wu et al.
Previous studies have reported that 99mTc-3PRGD2 is an excellent tumor imaging agent that showed a good correlation with integrin αvβ3, a main factor of tumor-induced angiogenesis. In this study, we investigated the biometabolic distribut...
Investigating the Relationship between Transverse Relaxation Rate (R2) and Interecho Time in MagA-Expressing, Iron-Labeled Cells [0.03%]
探讨MagA表达、铁标记细胞横向弛豫率(R2)与回波间隔时间的关系
Casey Y Lee,R Terry Thompson,Frank S Prato et al.
Casey Y Lee et al.
Reporter gene-based labeling of cells with iron is an emerging method of providing magnetic resonance imaging contrast for long-term cell tracking and monitoring cellular activities. This report investigates 9.4 T nuclear magnetic resonance...
Initial Assessment of β3-Adrenoceptor-Activated Brown Adipose Tissue in Streptozotocin-Induced Type 1 Diabetes Rodent Model Using [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography [0.03%]
streptozotocin致1型糖尿病rodent模型活体评估β3肾上腺素受体激活棕色脂肪组织的代谢活性：[18F]氟脱氧葡萄糖正电子发射断层显像/计算机断层扫描初步研究
Aparna Baranwal,M Reza Mirbolooki,Jogeshwar Mukherjee
Aparna Baranwal
Metabolic activity of brown adipose tissue (BAT) is activated by β3-adrenoceptor agonists and norepinephrine transporter (NET) blockers and is measurable using [(18)F]fluorodeoxyglucose ([(18)F]FDG) positron emission tomography/computed to...