First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease [0.03%]
人脑63Zn-葡萄酸锌的PET成像研究及其在阿尔茨海默病患者中的应用
Timothy R DeGrado,Bradley J Kemp,Mukesh K Pandey et al.
Timothy R DeGrado et al.
Abnormalities in zinc homeostasis are indicated in many human diseases, including Alzheimer disease (AD). 63Zn-zinc citrate was developed as a positron emission tomography (PET) imaging probe of zinc transport and used in a first-in-human s...
A Novel Copolymer-Based Functional SPECT/MR Imaging Agent for Asialoglycoprotein Receptor Targeting [0.03%]
一种新型的共聚物基功能型SPECT/MR影像剂用于靶向Asialoglycoprotein受体
Pu Zhang,Zhide Guo,Deliang Zhang et al.
Pu Zhang et al.
The aim of this study is to develop a copolymer-based single-photon emission computed tomography/magnetic resonance (SPECT/MR) dual-modality imaging agent that can be labeled with both technetium-99m (99mTc) and gadolinium (Gd) and target a...
Benjamin H Rotstein,Michael S Placzek,Hema S Krishnan et al.
Benjamin H Rotstein et al.
Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administr...
L-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies [0.03%]
L-酪氨酸赋予d-氨基酸富集的抗体内部化肽以残余性质，用于放射性碘标记的抗体内部化
Fook T Lee,Ingrid J G Burvenich,Nancy Guo et al.
Fook T Lee et al.
Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with (124)I to support clinical development using immuno-positron emission tomography (PET). ...
Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies [0.03%]
基于BGO的PET系统单细胞追踪性能的模拟和体模研究评估
Yu Ouyang,Tae Jin Kim,Guillem Pratx
Yu Ouyang
A recent method based on positron emission was reported for tracking moving point sources using the Inveon PET system. However, the effect of scanner background noise was not further explored. Here, we evaluate tracking with the Genisys4, a...
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma [0.03%]
色氨酸PET影像技术在胶质母细胞瘤患者源性异种移植物模型小鼠犬尿酸途径中的应用研究
Anthony R Guastella,Sharon K Michelhaugh,Neil V Klinger et al.
Anthony R Guastella et al.
Increasing evidence demonstrates the immunosuppressive kynurenine pathway's (KP) role in the pathophysiology of human gliomas. To study the KP in vivo, we used the noninvasive molecular imaging tracer α-[(11)C]-methyl-l-tryptophan (AMT). T...
Assessing Metabolic Changes in Response to mTOR Inhibition in a Mantle Cell Lymphoma Xenograft Model Using AcidoCEST MRI [0.03%]
利用AcidoCEST磁共振成像评估mTOR抑制对套细胞淋巴瘤移植瘤模型代谢变化的影响
Paul J Akhenblit,Neale T Hanke,Alexander Gill et al.
Paul J Akhenblit et al.
AcidoCEST magnetic resonance imaging (MRI) has previously been shown to measure tumor extracellular pH (pHe) with excellent accuracy and precision. This study investigated the ability of acidoCEST MRI to monitor changes in tumor pHe in resp...
Sofia M Pereira,Steve R Williams,Patricia Murray et al.
Sofia M Pereira et al.
Bacterial genes involved in the biomineralization of magnetic nanoparticles in magnetotactic bacteria have recently been proposed as reporters for magnetic resonance imaging (MRI). In such systems, the expression of the bacterial genes in m...
De Novo Glutamine Synthesis: Importance for the Proliferation of Glioma Cells and Potentials for Its Detection With 13N-Ammonia [0.03%]
从头合成谷氨酰胺的重要性：对于胶质瘤细胞增殖及使用13N-氨进行检测的潜力
Qiao He,Xinchong Shi,Linqi Zhang et al.
Qiao He et al.
Purpose: The aim of this study was to investigate the role of de novo glutamine (Gln) synthesis in the proliferation of C6 glioma cells and its detection with (13)N-ammonia. ...
Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging [0.03%]
使用[18F]DPA-714正电子发射断层扫描成像检测脑室内出血大鼠模型中神经炎症的方法
Clément Thomas,Johnny Vercouillie,Aurélie Doméné et al.
Clément Thomas et al.
Subarachnoid hemorrhage (SAH) can lead to delayed cerebral ischemia, which increases the rate of morbidity and mortality. The detection of microglial activation may serve as a biomarker for the identification of patients at risk of this del...