Preclinical Multimodal Molecular Imaging Using 18F-FDG PET/CT and MRI in a Phase I Study of a Knee Osteoarthritis in In Vivo Canine Model [0.03%]
一期临床试验中基于18F-FDG PET/CT和MRI的多模态分子影像在膝骨关节炎在体犬模型中的应用
Maria I Menendez,Bianca Hettlich,Lai Wei et al.
Maria I Menendez et al.
The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine ...
Targeted Imaging of Tumor-Associated Macrophages by Cyanine 7-Labeled Mannose in Xenograft Tumors [0.03%]
通过环糊精包合的Cy7-壳寡糖对移植肿瘤中肿瘤相关巨噬细胞进行成像研究
Chong Jiang,Huawei Cai,Xiaodong Peng et al.
Chong Jiang et al.
Mannose receptor is considered as a hallmark of M2-oriented tumor-associated macrophages (TAMs), but its utility in TAMs was rarely reported. Therefore, deoxymannose (DM), a high-affinity ligand of mannose receptor, was labeled with near-in...
Multimodal Imaging of Patients With Gliomas Confirms 11C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy [0.03%]
胶质瘤患者的多模式影像确认正电子发射断层扫描中的11C-甲硫氨酸摄取可作为磁共振成像对肿瘤分级和治疗后病情监测的补充指标
Kai R Laukamp,Florian Lindemann,Matthias Weckesser et al.
Kai R Laukamp et al.
The value of combined L-( methyl-[11C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicio...
PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury [0.03%]
血管炎性损伤颈动脉模型中的丝氨醇-1-磷酸受体1表达的正电子发射断层显像研究
Hui Liu,Hongjun Jin,Xuyi Yue et al.
Hui Liu et al.
Sphingosine-1-phosphate receptor (S1PR) activation plays a key role in vascular inflammatory response. Here, we report in vivo validation of [11C]TZ3321, a potent S1PR1 radioligand, for imaging vascular inflammation in a rat model of caroti...
Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI [0.03%]
结合SPECT/CT和MRI进行超小超顺磁性氧化铁99mTc标记的图像分析及动脉给药后肿瘤定位评估
In Joon Lee,Ji Yong Park,Young-Il Kim et al.
In Joon Lee et al.
The aim of this study is to evaluate the localization of 99mTc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered 99mTc-SPIO intravenously or intra-arterially...
Preclinical Evaluation of 18F-ML-10 to Determine Timing of Apoptotic Response to Chemotherapy in Solid Tumors [0.03%]
18F-ML-10体外实验决定化疗后实体瘤凋亡反应时间的评估研究
Emre Demirci,Rafay Ahmed,Meltem Ocak et al.
Emre Demirci et al.
Purpose: We investigated 2-(5-fluoro-pentyl)-2-methyl-malonic acid (18F-ML-10) positron emission tomography (PET) imaging of apoptosis posttherapy to determine optimal timing for predicting chemotherapy response in a mous...
Molecular Imaging of the Human Pulmonary Vascular Endothelium Using an Adrenomedullin Receptor Ligand [0.03%]
人肺血管内皮的分子影像：肾上腺髓质素受体配体的应用
François Harel,Xavier Levac,Quang T Nguyen et al.
François Harel et al.
This phase I study (NCT01539889) evaluated the safety, efficacy, and dosing of PulmoBind for molecular imaging of pulmonary circulation. PulmoBind is a ligand of the adrenomedullin receptor abundantly distributed in lung capillaries. Labele...
Rahima Chennoufi,Florence Mahuteau-Betzer,Patrick Tauc et al.
Rahima Chennoufi et al.
Photodynamic therapy (PDT) is a promising therapeutic method for several diseases, in particular for cancer. This approach uses a photosensitizer, oxygen, and an external light source to produce reactive oxygen species (ROS) at lethal doses...
Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions [0.03%]
αvβ6整合素示踪在胰腺癌及其前病变临床管理中的应用展望
Katja Steiger,Anna-Melissa Schlitter,Wilko Weichert et al.
Katja Steiger et al.
ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a hig...
In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis [0.03%]
类风湿关节炎动物模型活体PET分子影像免疫环境激活状态研究
Benjamin L Franc,Sam Goth,John MacKenzie et al.
Benjamin L Franc et al.
Background: Evolving immune-mediated therapeutic strategies for rheumatoid arthritis (RA) may benefit from an improved understanding of the complex role that T-cell activation plays in RA. This study assessed the potentia...