Rethinking Brain Cancer Therapy: Tumor Enzyme Activatable Theranostic Nanoparticles [0.03%]
重新思考脑癌治疗：肿瘤酶可激活诊疗一体化纳米颗粒疗法
Heike E Daldrup-Link
Heike E Daldrup-Link
This invited commentary discusses a recent article by Mohanty et al in Molecular Cancer Therapeutics about significant therapeutic efficacies of novel theranostic nanoparticles (TNPs) for the treatment of human brain cancers in mouse models...
Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT [0.03%]
利用正电子发射断层扫描和单光子发射计算机断层扫描技术对水解酶进行分子成像
Brian P Rempel,Eric W Price,Christopher P Phenix
Brian P Rempel
Hydrolytic enzymes are a large class of biological catalysts that play a vital role in a plethora of critical biochemical processes required to maintain human health. However, the expression and/or activity of these important enzymes can ch...
Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience [0.03%]
68Ga-柠檬酸盐显像在肝细胞癌中的首次临床应用体验
Carina Mari Aparici,Spencer C Behr,Youngho Seo et al.
Carina Mari Aparici et al.
While cross-sectional imaging with computed tomography (CT) and magnetic resonance imaging is the primary method for diagnosing hepatocellular carcinoma (HCC), they provide little biological insight into this molecularly heterogeneous disea...
Ex Vivo and In Vivo Noninvasive Imaging of Epidermal Growth Factor Receptor Inhibition on Colon Tumorigenesis Using Activatable Near-Infrared Fluorescent Probes [0.03%]
基于 activatable 近红外荧光探针的表皮生长因子受体抑制对结肠肿瘤发生学的体外和体内非侵入成像研究
Shengli Ding,Randall E Blue,Emily Moorefield et al.
Shengli Ding et al.
Background: Near-infrared fluorescence (NIRF) imaging combined with enzyme-activatable NIRF probes has yielded promising results in cancer detection. Obje...
Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT [0.03%]
采用MicroPET / CT对禁食和非禁食自发性高血压大鼠心肌脂肪酸和葡萄糖代谢进行纵向评价
Jennifer S Huber,Andrew M Hernandez,Mustafa Janabi et al.
Jennifer S Huber et al.
Using longitudinal micro positron emission tomography (microPET)/computed tomography (CT) studies, we quantified changes in myocardial metabolism and perfusion in spontaneously hypertensive rats (SHRs), a model of left ventricular hypertrop...
Developing a Strategy for Interventional Molecular Imaging of Oxidized Low-Density Lipoprotein in Atherosclerosis [0.03%]
动脉粥样硬化氧化低密度脂蛋白介入分子影像策略的制定
Samata S Pandey,Dorian O Haskard,Ramzi Y Khamis
Samata S Pandey
The identification of vulnerable coronary artery atherosclerotic plaques offers the prospect of either localized or systematic therapeutic targeting in order to prevent myocardial infarction. Molecular imaging of atherosclerosis adds to mor...
Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent [0.03%]
PARP1靶向光学成像剂在口腔癌检测和界定中的应用
Susanne Kossatz,Wolfgang Weber,Thomas Reiner
Susanne Kossatz
More sensitive and specific methods for early detection are imperative to improve survival rates in oral cancer. However, oral cancer detection is still largely based on visual examination and histopathology of biopsy material, offering no ...
Near-Infrared Intraoperative Imaging Can Successfully Identify Malignant Pleural Mesothelioma After Neoadjuvant Chemotherapy [0.03%]
近红外术中影像能够成功识别新辅助化疗后的恶性间皮瘤
Jarrod D Predina,Andrew Newton,Greg Kennedy et al.
Jarrod D Predina et al.
Malignant pleural mesothelioma is a deadly disease. Complete surgical resection provides patients with the best opportunity for long-term survival. Unfortunately, identification of disease during resection can be challenging. In this report...
Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer [0.03%]
荧光引导手术联合光动力疗法治疗癌症
Jun He,Leping Yang,Wenjun Yi et al.
Jun He et al.
Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advant...
Imaging Neurotensin Receptor in Prostate Cancer With 64Cu-Labeled Neurotensin Analogs [0.03%]
铜-64标记神经紧张素类似物用于前列腺癌中神经紧张素受体显像
Huaifu Deng,Hui Wang,He Zhang et al.
Huaifu Deng et al.
Introduction: Neurotensin receptor 1 (NTR-1) is expressed and activated in prostate cancer cells. In this study, we explore the NTR expression in normal mouse tissues and study the positron emission tomography (PET) imagi...