Radiolabeled Anti-Adenosine Triphosphate Synthase Monoclonal Antibody as a Theragnostic Agent Targeting Angiogenesis [0.03%]
targeting新生血管的放射性标记抗腺苷三磷酸酶单克隆抗体治疗诊断剂
Bok-Nam Park,Su Jin Lee,Jung Hyun Roh et al.
Bok-Nam Park et al.
Introduction: The potential of a radioiodine-labeled, anti-adenosine triphosphate synthase monoclonal antibody (ATPS mAb) as a theragnostic agent for simultaneous cancer imaging and treatment was evaluated. ...
Molecular Imaging and Radionuclide Therapy of Melanoma Targeting the Melanocortin 1 Receptor [0.03%]
靶向黑色素皮质激素受体1的黑色素瘤分子影像学及放射性核素治疗
Chengcheng Zhang,Kuo-Shyan Lin,François Bénard
Chengcheng Zhang
Melanoma is a deadly disease at late metastatic stage, and early diagnosis and accurate staging remain the key aspects for managing melanoma. The melanocortin 1 receptor (MC1 R) is overexpressed in primary and metastatic melanomas, and its ...
Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With 18F-Fluorocholine Dual Time Point PET/MRI [0.03%]
18F-氟脱氧葡萄糖双时相PET/MRI新诊断前列腺癌的定量测量和定性评估中飞行时间及正则化重建的影响研究
Spencer C Behr,Brett J Mollard,Jaewon Yang et al.
Spencer C Behr et al.
Recent technical advances in positron emission tomography/magnetic resonance imaging (PET/MRI) technology allow much improved time-of-flight (TOF) and regularized iterative PET reconstruction regularized iterative reconstruction (RIR) algor...
Comparative Study
Molecular imaging. 2017 Jan-Dec:16:1536012117736703. DOI:10.1177/1536012117736703 2017
Yingying Sun,Xilin Sun,Baozhong Shen
Yingying Sun
The important role of insulin-like growth factor 1 receptor (IGF-1R) in malignant tumors has been well established. Increased IGF-1R activity promotes cancer cell proliferation, migration, and invasion and is associated with tumor metastasi...
Radiochemistry and Preclinical PET Imaging of 68Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen [0.03%]
68Ga-脱铁氧肟素放射性示踪剂标记前列腺特异性膜抗原的放射化学及临床前PET成像研究
Eleni Gourni,Luigi Del Pozzo,Mark Bartholomä et al.
Eleni Gourni et al.
Radiotracers incorporating the urea-based Glu-NH-C(O)-NH-Lys group have gained prominence due to their role in targeting prostate-specific membrane antigen (PSMA)-a clinical biomarker of prostate cancer. Here, the synthesis, radiolabeling, ...
Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [11C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism [0.03%]
[11C]棕榈酸的全身生物分布、剂量学和代谢物校正：一种用于脂肪酸代谢成像的PET示踪剂
Nana L Christensen,Steen Jakobsen,Anna C Schacht et al.
Nana L Christensen et al.
Introduction: Despite the decades long use of [11C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data ha...
Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET [0.03%]
通过PET确认ROS1/ALK抑制剂洛拉替尼穿透大脑
T Lee Collier,Kevin P Maresca,Marc D Normandin et al.
T Lee Collier et al.
The Massachusetts General Hospital Radiochemistry Program, in collaboration with Pfizer, has developed unique 11C and 18F-labeling strategies to synthesize isotopologs of lorlatinib (PF-06463922) which is undergoing phase III clinical trial...
First-in-Man Evaluation of 124I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment [0.03%]
人首次实验评估124I-PGN650：一种检测磷脂酰丝氨酸的PET示踪剂，作为实体肿瘤微环境生物标志物的试验
Richard Laforest,Farrokh Dehdashti,Yongjian Liu et al.
Richard Laforest et al.
Purpose: PGN650 is a F(ab')2 antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in resp...
Whole-Body Distribution of Leukemia and Functional Total Marrow Irradiation Based on FLT-PET and Dual-Energy CT [0.03%]
基于FLT-PET和双能CT的白血病全身分布及功能总髓 irradiation
Taiki Magome,Jerry Froelich,Shernan G Holtan et al.
Taiki Magome et al.
This report describes a multimodal whole-body 3'-deoxy-3'[(18)F]-fluorothymidine positron emission tomography (FLT-PET) and dual-energy computed tomography (DECT) method to identify leukemia distribution within the bone marrow environment (...
The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates [0.03%]
寻找GABAA受体复合物亚型选择性PET成像剂的研究：[11C]ADO放射示踪剂的非人灵长类动物评估研究
Shu-Fei Lin,Frederic Bois,Daniel Holden et al.
Shu-Fei Lin et al.
The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABAA, GABAB, and GABAC groups. The various GABAA subunits with region-specific distributions in t...