Pharmacokinetic Evaluation of [11C]CEP-32496 in Nude Mice Bearing BRAFV600E Mutation-Induced Melanomas [0.03%]
裸鼠BRAFV600E诱导黑色素瘤中[11C]CEP-32496的药代动力学评价
Cuiping Jiang,Lin Xie,Yiding Zhang et al.
Cuiping Jiang et al.
CEP-32496, also known as RXDX-105 or Agerafenib, is a new orally active inhibitor for the mutated v-raf murine sarcoma viral oncogene homolog B1 (BRAFV600E), which has attracted considerable attention in clinical trials for the treatment of...
Rare-Earth-Doped Nanoparticles for Short-Wave Infrared Fluorescence Bioimaging and Molecular Targeting of αVβ3-Expressing Tumors [0.03%]
用于αvβ3阳性肿瘤短波红外荧光生物成像和分子靶向的稀土掺杂纳米颗粒
Dominik Jan Naczynski,Jason H Stafford,Silvan Türkcan et al.
Dominik Jan Naczynski et al.
The use of short-wave infrared (SWIR) light for fluorescence bioimaging offers the advantage of reduced photon scattering and improved tissue penetration compared to traditional shorter wavelength imaging approaches. While several nanomater...
The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils [0.03%]
BF-227类似苯并噁唑与人α-突触核蛋白和淀粉样蛋白β肽纤维的结合
Lee Josephson,Nancy Stratman,YuTing Liu et al.
Lee Josephson et al.
Development of an α-synuclein (α-Syn) positron emission tomography agent for the diagnosis and evaluation of Parkinson disease therapy is a key goal of neurodegenerative disease research. BF-227 has been described as an α-Syn binder and ...
From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale [0.03%]
从微米到纳米的多功能诊疗平台：有效的超声成像不仅仅是尺度问题
Sara Zullino,Monica Argenziano,Ilaria Stura et al.
Sara Zullino et al.
Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with diameters between 1 and 10 µm have been used for a number of decades in diagnostic imaging. In recent years, submicron contrast agents have proven to...
Acute Ketamine Infusion in Rat Does Not Affect In Vivo [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5 [0.03%]
急性氯胺酮输注不影响大鼠体内[11C]ABP688与代谢型谷氨酸受体5的结合
Lauren Kosten,Jeroen Verhaeghe,Leonie Wyffels et al.
Lauren Kosten et al.
Detecting changes in metabotropic glutamate receptor 5 (mGluR5) availability through molecular imaging with the positron emission tomography (PET) tracer [11C]ABP688 is valuable for studying dysfunctional glutamate transmission associated w...
Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO [0.03%]
神经退行性疾病中新兴的正电子发射断层扫描放射示踪剂和神经炎症成像靶点：超出TSPO展望
Vidya Narayanaswami,Kenneth Dahl,Vadim Bernard-Gauthier et al.
Vidya Narayanaswami et al.
The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain's resident macrophages, microglia. Although initiation of an inflammato...
Mariya Shapovalova,Sean R Pyper,Branden S Moriarity et al.
Mariya Shapovalova et al.
The recent success of autologous T cell-based therapies in hematological malignancies has spurred interest in applying similar immunotherapy strategies to the treatment of solid tumors. Identified nearly 4 decades ago, natural killer (NK) c...
Evaluation of a Tumor-Targeting, Near-Infrared Fluorescent Peptide for Early Detection and Endoscopic Resection of Polyps in a Rat Model of Colorectal Cancer [0.03%]
评估肿瘤靶向近红外荧光肽在 rats模型中结直肠癌息肉早期检测和内镜切除中的应用效果
Jade E Jones,Susheel Bhanu Busi,Jonathan B Mitchem et al.
Jade E Jones et al.
The goal of these studies was to use a tumor-targeting, near-infrared (NIR) fluorescent peptide to evaluate early detection and to guide surgical removal of polyps in a genetically engineered rat model of spontaneous colorectal cancer. This...
Capturing Bone Signal in MRI of Pelvis, as a Large FOV Region, Using TWIST Sequence and Generating a 5-Class Attenuation Map for Prostate PET/MRI Imaging [0.03%]
利用TWIST序列捕获骨信号并生成前列腺PET/MRI影像的五级衰减图
Mehdi Shirin Shandiz,Hamid Saligheh Rad,Pardis Ghafarian et al.
Mehdi Shirin Shandiz et al.
Purpose: Prostate imaging is a major application of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI). Currently, MRI-based attenuation correction (MRAC) for whole-body PET/MRI in which the bony str...
Quantification of Cerenkov Luminescence Imaging (CLI) Comparable With 3-D PET Standard Measurements [0.03%]
切伦科夫发光成像（CLI）的量化与三维PET标准测量相比
Frezghi Habte,Arutselvan Natarajan,David S Paik et al.
Frezghi Habte et al.
Cerenkov luminescence imaging (CLI) is commonly performed using two-dimensional (2-D) conventional optical imaging systems for its cost-effective solution. However, quantification of CLI comparable to conventional three-dimensional positron...