Analysis of Progress and Challenges of EGFR-Targeted Molecular Imaging in Cancer With a Focus on Affibody Molecules [0.03%]
基于Affibody分子的EGFR靶向癌症分子影像研究进展与挑战分析
Weizhi Chen,Baozhong Shen,Xilin Sun
Weizhi Chen
Epidermal growth factor receptor (EGFR)-targeted cancer therapy requires an accurate estimation of EGFR expression in tumors to identify responsive patients, monitor therapeutic effect, and estimate prognosis. The EGFR molecular imaging is ...
Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Met Mouse Model of Autism [0.03%]
自闭症代谢型小鼠模型中脑功能连接与神经递质释放异常的研究
Shiyu Tang,Elizabeth M Powell,Wenjun Zhu et al.
Shiyu Tang et al.
MET, the gene encoding the tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility gene for autism spectrum disorder (ASD). Genetically altered mice with a kinase-inactive Met offer a potential model for understanding neu...
PET Imaging of Hepatocellular Carcinomas: 18F-Fluoropropionic Acid as a Complementary Radiotracer for 18F-Fluorodeoxyglucose [0.03%]
肝细胞癌的正电子发射断层显像：18F-氟丙酸作为18F-脱氧葡萄糖的补充放射示踪剂
Jing Zhao,Zhanwen Zhang,Dahong Nie et al.
Jing Zhao et al.
Objective: To evaluate the preclinical value of 18F-fluoropropionic acid (18F-FPA) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for imaging HCCs. ...
A Simple Ex Vivo Semiquantitative Fluorescent Imaging Utilizing Planar Laser Scanner: Detection of Reactive Oxygen Species Generation in Mouse Brain and Kidney [0.03%]
一种简单方便的基于平面激光扫描仪的体外荧光成像技术及其在小鼠脑和肾脏内活性氧检测中的应用
Rie Hosoi,Sota Sato,Miho Shukuri et al.
Rie Hosoi et al.
Objective: Oxidative stress plays an important role in the onset of many neuronal and peripheral disorders. We examined the feasibility of obtaining semiquantitative fluorescent images of reactive oxygen species (ROS) gen...
Development and Characterization of an 18F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor [0.03%]
一种用于成像心脏生长激素释放素受体的18F标记胃泌素肽 mimetic的开发与表征
Ahmed Abbas,Lihai Yu,Tyler Lalonde et al.
Ahmed Abbas et al.
One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular a...
Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases [0.03%]
磁共振成像表征鸡胚胎癌细胞转移模型
Anne Herrmann,Arthur Taylor,Patricia Murray et al.
Anne Herrmann et al.
Metastasis is the most common cause of death for patients with cancer. To fully understand the steps involved in metastatic dissemination, in vivo models are required, of which murine ones are the most common. Therefore, preclinical imaging...
Kendra S Carmon,Ali Azhdarinia
Kendra S Carmon
Targeted therapies hold great promise for cancer treatment and may exhibit even greater efficacy when combined with patient selection tools. The clinical impact of identifying likely responders includes reducing the number of unnecessary an...
Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET [0.03%]
金刚烷/瓜环：免疫PET潜在的前靶向成像策略
Martin G Strebl,Jane Yang,Lyle Isaacs et al.
Martin G Strebl et al.
Positron emission tomography (PET) imaging with biological macromolecules greatly expands the possibilities of molecular imaging. There are, however, practical aspects limiting the potential of the approach, including the dosimetric consequ...
Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy [0.03%]
正常妊娠和病理妊娠下的胎盘超声引导光声成像的临床前研究
Liliya M Yamaleyeva,K Bridget Brosnihan,Lane M Smith et al.
Liliya M Yamaleyeva et al.
Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discuss...
Ying Xiong,Dahong Nie,Shaoyu Liu et al.
Ying Xiong et al.
Objective: To investigate the value of 2-(3-[18F]fluoropropyl)-2-methyl-malonic acid ([18F]ML-8) positron emission tomography (PET) imaging of rat pulmonary fibrosis. ...