Investigation of Inter- and Intratumoral Heterogeneity of Glioblastoma Using TOF-SIMS [0.03%]
使用TOF-SIMS研究胶质母细胞瘤的异质性
Samvel K Gularyan,Alexander A Gulin,Ksenia S Anufrieva et al.
Samvel K Gularyan et al.
Glioblastoma (GBM) is one of the most aggressive human cancers with a median survival of less than two years. A distinguishing pathological feature of GBM is a high degree of inter- and intratumoral heterogeneity. Intertumoral heterogeneity...
Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC [0.03%]
快速适应性分析表明BCL6可作为NSCLC的EGFR TKI联合疗法靶点
Yan Zhou Tran,Rezan Minozada,Xiaofang Cao et al.
Yan Zhou Tran et al.
Drug resistance is a major obstacle to curative cancer therapies, and increased understanding of the molecular events contributing to resistance would enable better prediction of therapy response, as well as contribute to new targets for co...
Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC [0.03%]
立即适应性分析将BCL6鉴定为NSCLC中与EGFR-TKI联合疗法的靶点
Yan Zhou Tran,Rezan Minozada,Xiaofang Cao et al.
Yan Zhou Tran et al.
Drug resistance is a major obstacle to curative cancer therapies, and increased understanding of the molecular events contributing to resistance would enable better prediction of therapy response, as well as contribute to new targets for co...
Selection of Features with Consistent Profiles Improves Relative Protein Quantification in Mass Spectrometry Experiments [0.03%]
具有稳定谱图的蛋白质特征选择可提高基于质谱分析的相对定量精度
Tsung-Heng Tsai,Meena Choi,Balazs Banfai et al.
Tsung-Heng Tsai et al.
In bottom-up mass spectrometry-based proteomics, relative protein quantification is often achieved with data-dependent acquisition (DDA), data-independent acquisition (DIA), or selected reaction monitoring (SRM). These workflows quantify pr...
Selection of Features with Consistent Profiles Improves Relative Protein Quantification in Mass Spectrometry Experiments [0.03%]
具有相一致轮廓的特征选择可提高质谱实验中的蛋白质相对定量效果
Tsung-Heng Tsai,Meena Choi,Balazs Banfai et al.
Tsung-Heng Tsai et al.
In bottom-up mass spectrometry-based proteomics, relative protein quantification is often achieved with data-dependent acquisition (DDA), data-independent acquisition (DIA), or selected reaction monitoring (SRM). These workflows quantify pr...
Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling [0.03%]
对棕色脂肪细胞的蛋白质组和磷酸化蛋白质组分析发现RICTOR缺失削弱整体胰岛素 /AKT信号传导
Samuel W Entwisle,Camila Martinez Calejman,Anthony S Valente et al.
Samuel W Entwisle et al.
Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study...
Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling [0.03%]
对富脂棕色脂肪细胞的蛋白质组和磷酸化蛋白质组分析发现RICTOR丢失削弱总体胰岛素/AKT信号通路
Samuel W Entwisle,Camila Martinez Calejman,Anthony S Valente et al.
Samuel W Entwisle et al.
Stimulating brown adipose tissue (BAT) activity represents a promising therapy for overcoming metabolic diseases. mTORC2 is important for regulating BAT metabolism, but its downstream targets have not been fully characterized. In this study...
DEqMS: A Method for Accurate Variance Estimation in Differential Protein Expression Analysis [0.03%]
DEqMS：差分蛋白质表达分析中精确方差估计的方法
Yafeng Zhu,Lukas M Orre,Yan Zhou Tran et al.
Yafeng Zhu et al.
Quantitative proteomics by mass spectrometry is widely used in biomarker research and basic biology research for investigation of phenotype level cellular events. Despite the wide application, the methodology for statistical analysis of dif...
DEqMS: A Method for Accurate Variance Estimation in Differential Protein Expression Analysis [0.03%]
DEqMS：差分蛋白质表达分析中精确方差估计的方法
Yafeng Zhu,Lukas M Orre,Yan Zhou Tran et al.
Yafeng Zhu et al.
Quantitative proteomics by mass spectrometry is widely used in biomarker research and basic biology research for investigation of phenotype level cellular events. Despite the wide application, the methodology for statistical analysis of dif...
Anne-Claude Gingras,Steven A Carr,Alma L Burlingame
Anne-Claude Gingras