Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses [0.03%]
蛋白质组分析揭示人诱导多能干细胞神经元中突变Tau引起的细胞外囊泡载物失调
Sonia Podvin,Alexander Jones,Qing Liu et al.
Sonia Podvin et al.
Accumulation and propagation of hyperphosphorylated Tau (p-Tau) is a common neuropathological hallmark associated with neurodegeneration of Alzheimer's disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)...
Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation [0.03%]
定量蛋白质组学分析在体内采集的人类心脏样本揭示了无心房颤动的扩张左心耳的重塑蛋白图谱
Nora Linscheid,Pi Camilla Poulsen,Ida Dalgaard Pedersen et al.
Nora Linscheid et al.
Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps of protein expression in hearts of living humans are still lacking. Using samples obtained during valve re...
Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation [0.03%]
定量分析在体采集的人类心脏样本蛋白质组揭示了非房颤患者扩大左心耳的重塑蛋白图谱
Nora Linscheid,Pi Camilla Poulsen,Ida Dalgaard Pedersen et al.
Nora Linscheid et al.
Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps of protein expression in hearts of living humans are still lacking. Using samples obtained during valve re...
Characterization of Prenylated C-terminal Peptides Using a Thiopropyl-based Capture Technique and LC-MS/MS [0.03%]
基于硫代丙基捕获技术和LC-MS/MS表征异戊二烯化C端肽类物质
James A Wilkins,Krista Kaasik,Robert J Chalkley et al.
James A Wilkins et al.
Posttranslational modifications play a critical and diverse role in regulating cellular activities. Despite their fundamentally important role in cellular function, there has been no report to date of an effective generalized approach to th...
Characterization of Prenylated C-terminal Peptides Using a Thiopropyl-based Capture Technique and LC-MS/MS [0.03%]
基于硫代丙基捕获技术和LC-MS/MS表征异戊二烯化C端肽类物质
James A Wilkins,Krista Kaasik,Robert J Chalkley et al.
James A Wilkins et al.
Posttranslational modifications play a critical and diverse role in regulating cellular activities. Despite their fundamentally important role in cellular function, there has been no report to date of an effective generalized approach to th...
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) [0.03%]
与强直性脊柱炎相关的内质网氨基肽酶2（ERAP2）对自然HLA-B*27：05配体组的调节作用
Elena Lorente,Miguel G Fontela,Eilon Barnea et al.
Elena Lorente et al.
The HLA-B*27:05 allele and the endoplasmic reticulum-resident aminopeptidases are strongly associated with AS, a chronic inflammatory spondyloarthropathy. This study examined the effect of ERAP2 in the generation of the natural HLA-B*27:05 ...
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) [0.03%]
与强直性脊柱炎相关的内质网氨基肽酶2（ERAP2）对天然HLA-B*27:05配体组的调节作用
Elena Lorente,Miguel G Fontela,Eilon Barnea et al.
Elena Lorente et al.
The HLA-B*27:05 allele and the endoplasmic reticulum-resident aminopeptidases are strongly associated with AS, a chronic inflammatory spondyloarthropathy. This study examined the effect of ERAP2 in the generation of the natural HLA-B*27:05 ...
Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice [0.03%]
与肥胖相关糖尿病db/db小鼠β细胞适应性灵活性补偿相关的信号通路的表征
Taewook Kang,Brandon B Boland,Pia Jensen et al.
Taewook Kang et al.
The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to ob...
Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice [0.03%]
与肥胖相关糖尿病db/db小鼠β细胞适应性柔韧性补偿相关的信号通路的特征分析
Taewook Kang,Brandon B Boland,Pia Jensen et al.
Taewook Kang et al.
The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to ob...
Investigation of Inter- and Intratumoral Heterogeneity of Glioblastoma Using TOF-SIMS [0.03%]
利用TOF-SIMS研究胶质母细胞瘤的异质性
Samvel K Gularyan,Alexander A Gulin,Ksenia S Anufrieva et al.
Samvel K Gularyan et al.
Glioblastoma (GBM) is one of the most aggressive human cancers with a median survival of less than two years. A distinguishing pathological feature of GBM is a high degree of inter- and intratumoral heterogeneity. Intertumoral heterogeneity...