TMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer [0.03%]
基于TMT的Orbitrap Astral质谱仪组学（化学）蛋白质组学
Yuchen He,Ka Yang,Shaoxian Li et al.
Yuchen He et al.
Ongoing advancements in instrumentation has established mass spectrometry (MS) as an essential tool in proteomics research and drug discovery. The newly released Asymmetric Track Lossless (Astral) analyzer represents a major step forward in...
Quantitative proteomics and phosphoproteomics analysis of patient-derived ovarian cancer stem cells [0.03%]
患者来源的卵巢癌干细胞的定量蛋白质组学和磷酸化蛋白质组学分析
Giulia Franciosa,Valentina Nieddu,Chiara Battistini et al.
Giulia Franciosa et al.
High-grade serous ovarian carcinoma (HGSOC) is the deadliest gynecologic cancer. Key to the progression and ultimate lethality of this subtype is the intra-tumoral heterogeneity (ITH), which is defined as the coexistence of different cell t...
Omics analyses uncover host networks defining virus-permissive and -hostile cellular states [0.03%]
组学分析揭示了定义细胞病毒允许和抵抗状态的宿主网络
Honglin Chen,Philip D Charles,Quan Gu et al.
Honglin Chen et al.
The capacity of host cells to sustain or restrict virus infection is influenced by their proteome. Understanding the compendium of proteins defining cellular permissiveness is key to many questions in fundamental virology. Here, we apply a ...
Serum Disease-specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry [0.03%]
基于质谱分析的糖尿病视网膜病变血清病灶特异性IgG Fc岩藻糖基化糖链生物标志物筛选研究
Yishuang Mao,Jiyun Zhang,Yixin Zhang et al.
Yishuang Mao et al.
Purpose: To investigate the potential of serum disease-specific immunoglobulin G (DSIgG) crystallizable fragment (Fc) N-glycosylation as a diagnostic biomarker for the identification of nonproliferative and proliferative ...
ERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cells [0.03%]
ERAP1活性调节免疫肽组学，但也会影响癌细胞的蛋白质组、代谢和压力反应
Martha Nikopaschou,Martina Samiotaki,Elli-Anna Stylianaki et al.
Martha Nikopaschou et al.
Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I). However, it may have additional ef...
Ursula M Glocker,Florian Braun,H Christian Eberl et al.
Ursula M Glocker et al.
The efficacy and safety of kinase inhibitor drugs are largely influenced by their selectivity. Available profiling technologies are primarily based on over-expressed or endogenously expressed kinases in cell extracts. We compared kinase cap...
Cold Atmospheric Plasma Jet Promotes Wound Healing through CK2-coordinated PI3K/AKT and MAPK Signaling Pathways [0.03%]
冷等离子体促进伤口愈合的机制研究
Pei-Shan Wu,Tzu-Hsuan Wong,Chun-Wei Hou et al.
Pei-Shan Wu et al.
The promising role of cold atmospheric plasma jet (CAPJ) treatment in promoting wound healing has been widely documented in therapeutic implications. However, the fact that not all subjects respond equally to CAPJ necessitates the investiga...
CellEKT: a robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors [0.03%]
一种稳健的化学蛋白质组学工作流程 可用于绘制激酶抑制剂的作用靶点谱
Joel Rüegger,Berend Gagestein,Antonius P A Janssen et al.
Joel Rüegger et al.
The human genome encodes 518 protein kinases that are pivotal for drug discovery in various therapeutic areas such as cancer and autoimmune disorders. The majority of kinase inhibitors target the conserved ATP-binding pocket, making it diff...
Multi-Omics Analysis Unveils Nsun5-Mediated Molecular Alterations in the Somatosensory Cortex and its Impact on Pain Sensation [0.03%]
多组学分析揭示NSUN5介导的感觉皮层分子改变及其对痛觉的影响
Peipei Chen,Heyu Zhao,Xia Gao et al.
Peipei Chen et al.
Nsun5 assumes a pivotal role in the regulation of RNA methylation, and its deficiency has been linked to the advancement of hepatocellular carcinoma, gliomas, tetralogy of Fallot, cognitive deficits in Williams-Beuren syndrome (WBS), and br...
Offset mass carrier proteome improves quantification of multiplexed single cell proteomics [0.03%]
用于改善单细胞蛋白质组学多重分析定量的补偿质载体蛋白质组学
Tommy K Cheung,Ying Zhu,Christopher M Rose
Tommy K Cheung
Multiplexed single cell proteomics by mass spectrometry (scpMS) approaches currently offer the highest throughput as measured by cells analyzed per day. These methods employ isobaric labels and typically a carrier proteome - a sample added ...