Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential [0.03%]
多聚核糖体分析与等位基因特异性蛋白质组学鉴定出一个EIF4H的转录SNP变异型具有更高的翻译潜能
Meriem Hadjer Hamadou,Laura Alunno,Daniele Peroni et al.
Meriem Hadjer Hamadou et al.
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116 colorectal adenocarcinoma-derived cells, computing allelic fractions from both total and ...
Exploring an Intermediate Colorectal Cancer Screening Test Based on Stool Proteomics and Machine Learning for Optimizing the Selection of Patients for Colonoscopy Identified from FIT [0.03%]
基于粪便蛋白质组学和机器学习的肠镜筛查阳性受试者优选化中间阶段结直肠癌筛查试验的研究
David Gagné,Elmira Shajari,Mandy Malick et al.
David Gagné et al.
The fecal immunochemical test (FIT) for detecting fecal occult blood, used alone or in combination with other stool biomarkers, has been demonstrated to be effective in the context of colorectal cancer (CRC) screening programs. However, FIT...
Spatial Profiling of Glycosaminoglycans (GAGomics) from Laser Microdissected Mouse Brain [0.03%]
激光显微切割小鼠大脑糖胺聚糖（GAGomics）的空间谱型分析
Elias Mernie,Joseph Zaia
Elias Mernie
Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides composed of repeating disaccharide units. Heparan sulfate (HS) and chondroitin sulfate (CS) are highly sulfated GAG classes, ubiquitously expressed in mammalian tissue...
Deciphering the Protein Phosphorylation Dynamics Triggered by Seconds of Force Stimulation [0.03%]
揭秘几秒钟力刺激引发的蛋白质磷酸化动力学
Nan Yang,Sunny Sing Pun,Emily Oi Ying Wong et al.
Nan Yang et al.
Plants perceive mechanical forces through specialized phosphosignaling networks, yet how they are correlated with gravity force signaling remains unclear. To unravel the components of gravity force signalling, SILIA-based phosphoproteomics ...
pmultiqc: An open-source, lightweight, and metadata-oriented QC reporting library for MS proteomics [0.03%]
PMultiQC：一种开源、轻量级和以元数据为导向的质控报告库用于MS蛋白质组学
Qi-Xuan Yue,Chengxin Dai,Selvakumar Kamatchinathan et al.
Qi-Xuan Yue et al.
The increasing scale and complexity of proteomics data demand robust, scalable, and interpretable quality control (QC) frameworks to ensure data reliability and reproducibility. Here, we present pmultiqc, an open-source Python package that ...
An Evolutionary Distinct Nipah Virus N-Glycosylation Site Provides Stability for Receptor Engagement [0.03%]
一个进化上独特的尼帕病毒N-糖基化位点可提供稳定性以供受体结合
Tia E Hawkins,Valeria Calvaresi,Sean A Burnap et al.
Tia E Hawkins et al.
Nipah virus is a deadly paramyxovirus with 40-75% mortality and >750 cases since 1998. Currently there are no clinically approved vaccines or therapeutics to treat infection. Nipah is an enveloped virus with two surface glycoproteins, the t...
Cell-state specific drug-responses are associated with differences in signaling network wiring [0.03%]
细胞状态特异的药物反应与信号网络结构差异有关
Niels Krämer,Roderick van Eijl,Tim Stohn et al.
Niels Krämer et al.
Intracellular signaling pathways form networks through which information is transmitted, often in the form of kinase-mediated phosphorylation events, to interpret extracellular signals and elicit appropriate cellular responses. Yet, even is...
Widespread ncaas Imprints in the Serum Proteome of COVID-19 Convalescents Uncovering Immune System Sequelae [0.03%]
发现新冠肺炎恢复期血清蛋白组中普遍存在NCAAS印迹揭示免疫系统后遗症
Kun Liu,Zhigang Ren,Bowen Dong et al.
Kun Liu et al.
Post-COVID-19 sequelae has become an emerging global health issue, but the mechanisms for the sustained susceptibility of convalescents to the sequelae remain poorly understood. Here we report the use of a restricted open-search approach to...
Subcellular proteomic analyses reveal REEP5 knockdown in the mouse heart disrupts mitochondrial networks [0.03%]
亚细胞蛋白质组分析揭示小鼠心脏中REEP5敲低会破坏线粒体网络
Michelle Di Paola,Cristine J Reitz,Uros Kuzmanov et al.
Michelle Di Paola et al.
Receptor Expression-Enhancing Protein 5 (REEP5) is a cardiac-enriched, membrane-shaping protein localized to the sarco(endo)plasmic reticulum (SR/ER), where it supports membrane network architecture and cardiomyocyte function. While REEP5 h...
Characterization of Usher Syndrome Type 2-Associated Proteins in the Retina via Affinity Purification-Mass Spectrometry [0.03%]
通过亲和纯化-质谱法表征视网膜中与Usher综合征Ⅱ型相关的蛋白质
Junhuang Zou,Dongmei Yu,Pranav Dinesh Mathur et al.
Junhuang Zou et al.
Usher syndrome is the leading cause of inherited deaf-blindness, with type 2 (USH2) being the most common form. USH2A, ADGRV1, and WHRN are the three known USH2 causative genes, which are also linked to isolated retinal degeneration and hea...