Deciphering the proteomic profile of the parasite Fasciola hepatica after initial vertebrate host infection reveals new insights into its early-stages [0.03%]
解码肝片吸虫初始感染脊椎动物宿主后的蛋白组特征 提供对其早期发育的新见解
Marta López-García,Krystyna Cwiklinski,David Becerro-Recio et al.
Marta López-García et al.
The migration of the trematode parasite Fasciola hepatica within its vertebrate host following infection by ingestion of the metacercariae represents a critical event in its establishment and survival. The early stages of infection, during ...
msqrob2TMT: robust linear mixed models for inferring differential abundant proteins in labelled experiments with arbitrarily complex design [0.03%]
MSQRob2TMT：用于推断复杂实验设计中标签丰度差异蛋白的稳健线性混合模型
Stijn Vandenbulcke,Christophe Vanderaa,Oliver Crook et al.
Stijn Vandenbulcke et al.
Labelling strategies in mass spectrometry (MS)-based proteomics enhance sample throughput by enabling the acquisition of multiplexed samples within a single run. However, contemporary experiments often involve increasingly complex designs, ...
P4PP: an universal shotgun proteomics data analysis pipeline for virus identification [0.03%]
P4PP：一种用于病毒鉴定的通用蛋白质组学数据分析流程
Armand Paauw,Evgeni Levin,Ingrid A I Voskamp-Visser et al.
Armand Paauw et al.
Humans can be infected by a wide variety of virus species. We developed a data analysis approach for shotgun proteomic data to detect these viruses. A proteome for pandemic preparedness (P4PP) pipeline, a corresponding database (P4PP v01), ...
Recent Advances in Mass Spectrometry-Based Studies of Post-translational Modifications in Alzheimer's Disease [0.03%]
基于质谱的阿尔茨海默病翻译后修饰研究最新进展
Feixuan Wu,Wei Li,Haiyan Lu et al.
Feixuan Wu et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. There are over 10 million new cases of AD each year worldwide, implying one new case every 3.2 seconds. Post-translational modification...
MSstatsTMT improves accuracy of thermal proteome profiling by trading off temperature treatments and biological replicates [0.03%]
MSstatsTMT通过以温度处理代替生物重复提高热蛋白组学分析的准确性
Amanda M Figueroa-Navedo,Rohan Kapre,Tushita Gupta et al.
Amanda M Figueroa-Navedo et al.
Thermal proteome profiling investigates protein-protein, protein-nucleic acid, or protein-drug interactions, and the impact of metabolite binding and post-translational modifications on these interactions. The experiments quantitatively cha...
Employing Expression-Matched Controls Enables High Confidence Proximity-Based Interactome Classification [0.03%]
利用表达匹配的对照组能够进行高置信度的邻近依赖性互作组分类
Fulin Jiang,Xuezhen Ge,Eric J Bennett
Fulin Jiang
Proximity labeling approaches have been widely utilized to define protein interactomes. Due to the inherent promiscuity of proximity labeling using TurboID-based approaches, identification and adoption of appropriate labeling controls is a ...
A Method for Comparing Proteins Measured in Serum and Plasma by Olink® Proximity Extension Assay [0.03%]
基于Olink®邻近延伸 assay测定的血清和血浆蛋白质比较方法学研究
Rawan Shraim,Caroline Diorio,Scott W Canna et al.
Rawan Shraim et al.
Accurate measurement of secreted proteins in serum and plasma is essential for understanding mechanisms and developing reliable biomarkers. Recent technological advancements, such as proximity extension assay (PEA), have enabled high-throug...
A Multi-Omics Framework for Decoding Disease Mechanisms: Insights from Methylmalonic Aciduria [0.03%]
一种解码疾病机制的多组学框架：甲基丙二酸尿症的新见解
Jianbo Fu,Vito R T Zanotelli,Cedric Howald et al.
Jianbo Fu et al.
The diverse perspectives offered by multi-omics data analysis can aid in identifying the most relevant molecular pathways involved in disease processes, and findings in one layer can substantiate findings in other layers of information. Int...
Data-independent Acquisition Proteomics Identifies Plasma Prostaglandin-H2D-isomerase as an Early Diagnostic Biomarker for STEMI and NSTEMI [0.03%]
数据非依赖性获取蛋白质组学鉴定出血浆前列腺素H2D异构酶是早期诊断STEMI和NSTEMI生物标志物
Hong-Mei Xue,Hai-Tao Hou,Yu Song et al.
Hong-Mei Xue et al.
Myocardial infarction (MI) including ST-elevated MI (STEMI) and non-ST-elevated MI (NSTEMI), remains a leading cause of death worldwide. This study aimed to identify the early diagnostic biomarkers for STEMI and NSTEMI. Plasma samples from ...
LncRNA MALAT1 facilitates HIV-1 replication by upregulation of CHCHD2 and downregulation of IFN-I expression [0.03%]
长链非编码RNA MALAT1通过上调CHCHD2和下调IFN-I表达促进HIV-1复制
Mei-Rong Wang,Cheng-Si Bai,Jian-Wei Dai et al.
Mei-Rong Wang et al.
Long noncoding RNAs (lncRNAs) are effective regulators of both RNA and protein functions throughout cell biology, including viral replication. Emerging studies have shown that lncRNAs activate or inhibit the replication and latency of HIV-1...