Marco Reverenna,Maike Wennekers Nielsen,Darian Stephan Wolff et al.
Marco Reverenna et al.
Accurate determination of protein sequences is central to biology. Protein-based therapeutics, such as antibodies and nanobodies, are not encoded in reference genomes, challenging their accurate characterization via standard proteomics. Cur...
Non-Reducing Proteomics Reveals Disulfide-Dependent Proteoform Remodeling Under Oxidative Stress [0.03%]
非还原蛋白质组学揭示了氧化应激下二硫键依赖的蛋白亚型重构
Yeonjoo Lee,Tae-Kyung Kim,Seungjin Na et al.
Yeonjoo Lee et al.
Oxidative stress triggers redox-sensitive post-translational modifications, notably disulfide bond formation involving cysteine residues. However, these bonds are often overlooked in proteomics due to the routine use of reducing agents. Her...
Drosophila melanogaster miPEP8 regulates cell size through its interaction with ref(2)P/p62 [0.03%]
果蝇miPEP8通过与ref(2)P/p62的互作调控细胞大小
Carine Duboé,Clémence Guillon,Nathanael Jariais et al.
Carine Duboé et al.
MiPEPs are microproteins encoded by primary transcripts of microRNAs (pri-miRNAs). Initially identified in plants, we recently characterized a miPEP in Drosophila melanogaster, named miPEP8, which is involved in the regulation of wing size....
Interactome Analysis of the CC2D1A Scaffold Reveals Novel Neuronal Interactions and a Postsynaptic Role [0.03%]
CC2D1A支架互作组分析揭示了新的神经元相互作用及突触后功能
Abigail T Heller,Aniket Bhattacharya,Haorong Li et al.
Abigail T Heller et al.
Loss of the protein scaffold Coiled-coil and C2 domain containing 1A (CC2D1A) leads to intellectual disability (ID), autism spectrum disorder (ASD), and other neurodevelopmental presentations in humans. CC2D1A interactions have been studied...
Integrating MACSPI and SILAC for Neuron Type-Specific Proteomics in Caenorhabditis elegans [0.03%]
结合MACSPI和SILAC进行线虫神经元类型特异性蛋白质组学研究
Qiao Ran,Siyue Huang,Xiang David Li et al.
Qiao Ran et al.
Understanding neuronal differentiation and function requires precise proteomic characterization of distinct neuron types, yet existing methods face challenges in specificity and sensitivity. Here, we combine Methionine Analog-based Cell-Spe...
In vitro host-parasite models combined with proteomics reveal cell type-specific responses of early-migrating Fasciola hepatica juveniles [0.03%]
体外宿主-寄生虫模型结合蛋白质组学揭示早期迁移的肝片吸口囊幼虫细胞类型特异性反应
Marta López-García,Krystyna Cwiklinski,María Torres-Valle et al.
Marta López-García et al.
The trematode Fasciola hepatica has a complex life cycle involving two hosts. Infection of the definitive host, mainly livestock and humans, occurs through ingestion of the infective stage, the metacercariae, which excyst in the duodenum an...
Antibiotic resistance detection and concomitant species identification of ESKAPE pathogens by proteomics [0.03%]
抗药性检测及ESKAPE病原体的同时种属鉴定的蛋白质组学方法
Christian Blumenscheit,Yvonne Pfeifer,Guido Werner et al.
Christian Blumenscheit et al.
Antimicrobial resistance (AMR) is an increasing challenge for therapy of bacterial infections. Currently, patient treatment is guided by antimicrobial susceptibility testing (AST) using phenotypic assays and species identification by MALDI-...
mosna reveals different types of cellular interactions predictive of response to immunotherapies and survival in cancer [0.03%]
Mosna揭示了不同类型细胞相互作用可预测癌症免疫疗法反应和生存率
Alexis Coullomb,Colas Foulon,Bram van Haastrecht et al.
Alexis Coullomb et al.
Spatially resolved omics enable the discovery of tissue organization of biological or clinical importance. Despite the existence of several methods, performing a rational analysis including multiple algorithms while integrating different co...
An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways [0.03%]
整合型蛋白质转录组学方法揭示了新的ADAM9底物和下游途径
Congyu Lu,Xiaolu Xu,Neha Sindhu et al.
Congyu Lu et al.
The disintegrin metalloprotease ADAM9 is a cell-surface protease that can shed the ectodomain of membrane protein substrates. Dysregulated ADAM9 activity has been implicated in several diseases such as solid tumors, autoimmunity, inflammato...
High-fat diet and a high amyloid load interact to induce PKC-α dependent synaptic insulin resistance [0.03%]
高脂肪饮食和高淀粉样蛋白负荷相互作用，以PKC-α依赖性的方式诱导突触胰岛素抵抗
Alexander Wenger,Tingting Li,Chi Nguyen et al.
Alexander Wenger et al.
A plethora of studies suggest that a high-fat diet in combination with a high amyloid load causes synaptic insulin resistance and is a risk factor for Alzheimer's disease. Our understanding of the underlying mechanisms is still fragmented. ...