Resistin, Elastase, and Lactoferrin as Potential Plasma Biomarkers of Pediatric Inflammatory Bowel Disease Based on Comprehensive Proteomic Screens [0.03%]
基于全面蛋白质筛选的儿童炎症性肠病潜在血浆生物标志物 Resistin, Elastase 和 Lactoferrin
Anto Sam Crosslee Louis Sam Titus,Kamala Vanarsa,Sanam Soomro et al.
Anto Sam Crosslee Louis Sam Titus et al.
Inflammatory bowel disease (IBD) is an immune-mediated chronic inflammation of the intestine, which can present in the form of ulcerative colitis (UC) or as Crohn's disease (CD). Biomarkers are needed for reliable diagnosis and disease moni...
Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes [0.03%]
基于原生尺寸排阻色谱质谱技术揭示了限全局变化中的早期热休克蛋白90抑制反应新成分
Rahul S Samant,Silvia Batista,Mark Larance et al.
Rahul S Samant et al.
The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and malignant progression. Pharmacologic inhibitors of HSP90 have been...
Oxonium Ion-Guided Optimization of Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro [0.03%]
利用Oxonium离子优化timsTOF Pro的离子淌度辅助糖蛋白质组学研究
Soumya Mukherjee,Andris Jankevics,Florian Busch et al.
Soumya Mukherjee et al.
Spatial separation of ions in the gas phase, providing information about their size as collisional cross-sections, can readily be achieved through ion mobility. The timsTOF Pro (Bruker Daltonics) series combines a trapped ion mobility devic...
Thais Pereira-Veiga,Susana Bravo,Antonio Gómez-Tato et al.
Thais Pereira-Veiga et al.
Metastasis is the primary cause of death for most breast cancer (BC) patients who succumb to the disease. During the hematogenous dissemination, circulating tumor cells interact with different blood components. Thus, there are microenvironm...
MSstatsPTM: Statistical Relative Quantification of Posttranslational Modifications in Bottom-Up Mass Spectrometry-Based Proteomics [0.03%]
MSstatsPTM：基于自下而上质谱蛋白质组学中翻译后修饰的统计相对定量方法
Devon Kohler,Tsung-Heng Tsai,Erik Verschueren et al.
Devon Kohler et al.
Liquid chromatography coupled with bottom-up mass spectrometry (LC-MS/MS)-based proteomics is increasingly used to detect changes in posttranslational modifications (PTMs) in samples from different conditions. Analysis of data from such exp...
Proteomic Profiling Reveals the Molecular Control of Oocyte Maturation [0.03%]
蛋白质组学分析揭示了卵母细胞成熟的分子调控机制
Hongzheng Sun,Guangyi Sun,Haotian Zhang et al.
Hongzheng Sun et al.
Meiotic maturation is an intricate and precisely regulated process orchestrated by various pathways and numerous proteins. However, little is known about the proteome landscape during oocytes maturation. Here, we obtained the temporal prote...
An Optimized Proteomics Approach Reveals Novel Alternative Proteins in Mouse Liver Development [0.03%]
一种优化的蛋白质组学方法揭示了小鼠肝脏发育中的新型替代蛋白
Ying Yang,Hongwei Wang,Yuanliang Zhang et al.
Ying Yang et al.
Alternative ORFs (AltORFs) are unannotated sequences in genome that encode novel peptides or proteins named alternative proteins (AltProts). Although ribosome profiling and bioinformatics predict a large number of AltProts, mass spectrometr...
Mass Spectrometry-Driven Discovery of Neuropeptides Mediating Nictation Behavior of Nematodes [0.03%]
质谱推动的调节线虫尼克塔行为神经肽的发现
Bram Cockx,Sven Van Bael,Rose Boelen et al.
Bram Cockx et al.
Neuropeptides regulate animal physiology and behavior, making them widely studied targets of functional genetics research. While the field often relies on differential -omics approaches to build hypotheses, no such method exists for neurope...
Proteins in Tumor-Derived Plasma Extracellular Vesicles Indicate Tumor Origin [0.03%]
肿瘤衍生血浆细胞外囊泡中的蛋白质表明肿瘤来源
Meltem Barlin,Petra Erdmann-Gilmore,Jacqueline L Mudd et al.
Meltem Barlin et al.
Cancer-derived extracellular vesicles (EVs) promote tumorigenesis, premetastatic niche formation, and metastasis via their protein cargo. However, the proteins packaged by patient tumors into EVs cannot be determined in vivo because of the ...
Proteome Remodeling of the Eye Lens at 50 Years Identified With Data-Independent Acquisition [0.03%]
利用数据非依赖采集技术鉴定的50年眼 lens蛋白质组重塑
Lee S Cantrell,Romell B Gletten,Kevin L Schey
Lee S Cantrell
The eye lens is responsible for focusing and transmitting light to the retina. The lens does this in the absence of organelles, yet maintains transparency for at least 5 decades before onset of age-related nuclear cataract (ARNC). It is hyp...