O-mannose glycosylations influence E-cadherin functional interactions [0.03%]
O-岩藻糖基化作用影响E-钙黏着蛋白的功能相互作用
Shaoshuai Xie,Katarina Madunić,Omar G Rosas Bringas et al.
Shaoshuai Xie et al.
Cadherins are plasma membrane proteins that play critical roles in maintaining cell-cell adhesion and modulating cell signaling during development. Their functions are mediated by extracellular cadherin (EC) domains, which facilitate adhesi...
Natural product target identification of wheldone, a fungal metabolite, as a KIF11 inhibitor in ovarian cancer using the DiffPOP (Differential Protein Precipitation) method [0.03%]
利用DiffPOP（差异蛋白沉淀）方法鉴定卵巢癌中天尼他宁作为微管相关蛋白KIF11抑制剂的靶标作用
Manead Khin,Alejandra Cavazos Saldana,Manuel Rangel-Grimaldo et al.
Manead Khin et al.
Wheldone, a fungal metabolite, was identified as a cytotoxic compound in high-grade serous ovarian cancer (HGSOC). Wheldone induced caspase 3/7-dependent apoptosis and reduced migration, invasion, and spheroid growth. Wheldone stimulated ap...
Sec and Tat mediated secretion safeguards Mycobacterium tuberculosis membrane homeostasis [0.03%]
Sec和Tat介导的分泌守护结核分枝杆菌膜稳态
Priyadarshini Sanyal,Jagadeeshwari Uppada,Shashank Sinha et al.
Priyadarshini Sanyal et al.
Protein secretion is essential for the growth and virulence of Mycobacterium tuberculosis (Mtb), yet the organization and function of its secretion pathways remain poorly understood. We reviewed the existing literature, combined it with sys...
Glycoinformatic profiling of label-free intact heparan sulfate oligosaccharides [0.03%]
无标记完整硫酸肝素寡糖的糖信息学分析
Marissa L Maciej-Hulme,Jandi Kim,Elijah T Roberts et al.
Marissa L Maciej-Hulme et al.
Heparan sulfates (HS) are a group of heterogenous linear, sulfated polysaccharides that play a role in in health and many diseases including cancer, cardiovascular, and kidney diseases. The structural variety of HS has greatly challenged th...
Epithelial-mesenchymal transition shapes the lipotoxic response of colon cancer cells to palmitic acid [0.03%]
表皮间质转化塑造了结肠癌细胞对棕榈酸的脂毒反应
Francesco Vari,Ilaria Serra,Elisa Bisconti et al.
Francesco Vari et al.
Saturated fatty acids such as palmitic acid (PA) can induce lipotoxic stress, whereas monounsaturated fatty acids like oleic acid (OA) often promote adaptive responses through lipid droplets (LDs) formation. Here, we reveal that epithelial-...
Urine proteomics as a source of biological information and outcome predictor in living kidney transplantation [0.03%]
活体肾移植中的尿蛋白组学作为生物信息和预后预测的来源
K Johanna R Hoyer-Allo,Patrick Affeldt,Jan-Wilm Lackmann et al.
K Johanna R Hoyer-Allo et al.
Introduction: Kidney transplantation (KTx) is the preferred treatment for kidney failure, offering improved survival, quality of life and cost-effectiveness compared to dialysis. However, post-transplant management is cha...
3D Proteomics: structural, functional, chemical and biomarker discovery proteomics with LiP-MS [0.03%]
三维蛋白质组学：具有LiP-MS的结构、功能、化学和生物标志物发现蛋白质组学
Franziska Elsaesser,Natalie de Souza,Paola Picotti
Franziska Elsaesser
Protein structural dynamics drive changes in protein function, making their capture essential for interrogating biological systems. Here we review limited proteolysis coupled to mass spectrometry (LiP-MS), a structural and chemical proteomi...
Concepcion Sanchez,Igor H Wierzbicki,Charlie F Bayne et al.
Concepcion Sanchez et al.
Group A Streptococcus (Streptococcus pyogenes, GAS) is a bacterial pathogen that commonly causes local infections in humans and can lead to invasive diseases. GAS infections trigger complex host immune and tissue responses, yet how these pr...
Single Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm [0.03%]
单细胞蛋白质组揭示马方病小鼠动脉瘤的新细胞表型
Louis Saddic,Ashley Dinh,Giselle Kaneda et al.
Louis Saddic et al.
This report describes single-cell proteomic analyses of cells dissociated from a complex mammalian tissue using direct label-free mass spectrometry (SCP-MS). The nanoDTSC approach was applied to profile individual cells from aorta of male a...
Correction: Global Analysis of Protein and Small-Molecule Substrates of Ubiquitin-Like Proteins [0.03%]
订正：泛素样蛋白质的蛋白质和小分子底物的全球分析
Guang-Can Shao,Zhen-Lin Chen,Shan Lu et al.
Guang-Can Shao et al.