Shiri Karagach,Joachim Smollich,Ofir Atrakchi et al.
Shiri Karagach et al.
Single-cell mass spectrometry-based proteomics (SCP) can resolve cellular heterogeneity in complex biological systems and provide a system-level view of the proteome of each cell. Major advancements in SCP methodologies have been introduced...
Identification of Small Open Reading Frame-encoded Peptides in Glioma by an Optimized Proteomics Strategy [0.03%]
优化蛋白质组学策略识别胶质瘤中的小开放阅读框编码肽类分子
Tingting Zhang,Jian Cheng,Jiao Li et al.
Tingting Zhang et al.
Small open reading frame - encoded peptides (SEPs), translated from previously unannotated genomic regions, have emerged as important regulators in diverse physiological and pathological processes. While ribosome profiling and bioinformatic...
DHODH blockade induces ferroptosis in neuroblastoma by modulating the mevalonate pathway [0.03%]
DHODH阻滞通过调节甲羟戊酸途径诱导神经母细胞瘤铁死亡
Jui-Chia Shih,Pin-Yu Chen,Chuan-Hao Kuo et al.
Jui-Chia Shih et al.
Neuroblastoma is the most common heterogeneous solid tumor in children, and current treatment options remain limited, especially for high-risk patients. Previous studies have identified dihydroorotate dehydrogenase (DHODH), a key enzyme in ...
Cytosolic WPRa4 and Plastoskeletal PMI4 Proteins Mediate Touch Response in a Model Organism Arabidopsis [0.03%]
拟南芥细胞质WPRa4和质蓝骨架PMI4蛋白介导触摸响应
Kebin Wu,Nan Yang,Jia Ren et al.
Kebin Wu et al.
To elucidate the early signaling components involved in thigmomorphogenesis in Arabidopsis thaliana, we combined microscopy and proximity-labeling (PL)-based quantitative biotinylproteomics to characterize the touch-responsive putative cyto...
Proteomic profiling uncovers sexual dimorphism in the muscle response to wheel running exercise in the FLExDUX4 murine model of facioscapulohumeral muscular dystrophy [0.03%]
蛋白质组学谱分析发现FLExDUX4面肩肱肌营养不良小鼠模型在跑步运动中的性别差异响应
Yusuke Nishimura,Adam Bittel,Abhishek Jagan et al.
Yusuke Nishimura et al.
FLExDUX4 is a murine experimental model of facioscapulohumeral muscular dystrophy (FSHD) characterized by chronic, low levels of leaky expression of the human full-length double homeobox 4 gene (DUX4-fl). FLExDUX4 mice exhibit mild patholog...
From Discovery to Delivery: A Rapid and Targeted Proteomics Workflow for Monitoring Chinese Hamster Ovary Biomanufacturing [0.03%]
从发现到交付：用于监测中国仓鼠卵巢生物制造的快速且具有针对性的蛋白质组学工作流程
Charles Eldrid,Ellie Hawke,Kathleen M Cain et al.
Charles Eldrid et al.
Chinese hamster ovary (CHO) cells are the industrial workhorse for manufacturing biopharmaceuticals, including monoclonal antibodies. CHO cell line development requires a more data-driven approach for the accelerated identification of hyper...
Soluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates [0.03%]
可溶性VCAM-1可能是监测非人灵长类动物BACE2活性的药理学CSF标志物
Sarah K Tschirner,Joy Yu Zuchero,Jennifer A Getz et al.
Sarah K Tschirner et al.
The β-secretase β-site APP cleaving enzyme 1 (BACE1) is a major drug target for Alzheimer's disease (AD). Clinically tested BACE1 inhibitors induced unexpected cognitive side effects that may stem from their cross-inhibition of the homolo...
Closer Peptide Repertoire Similarity of HLA-B*14:03 and HLA-B*27:05 Sheds Light on Ankylosing Spondylitis Susceptibility [0.03%]
HLA-B*14:03与HLA-B*27:05肽谱系相似度较高，对强直性脊柱炎的易感性提供新的见解
Laura Cobos-Figueroa,Javier Robles-Parrado,Elisenda Alari-Pahissa et al.
Laura Cobos-Figueroa et al.
The human major histocompatibility complex class I (HLA-I) gene HLA-B*27 is the main risk factor for the rheumatic disease ankylosing spondylitis (AS) through an unknown mechanism. However, in African populations, where B*27 is rare, the B*...
PTMFusionNet: A Deep Learning Approach for Predicting Disease Related Post-Translational Modification and Classifying Disease Subtypes [0.03%]
基于深度学习的预测与疾病相关翻译后修饰和分类疾病的亚型的方法
Jie Ni,Yifan Zhou,Bin Li et al.
Jie Ni et al.
With the advancement of technologies such as mass spectrometry, it has become possible to simultaneously perform large-scale detection of protein intensity and corresponding post-translational modification (PTM) information, thereby facilit...
UniScore, a unified and universal measure for peptide identification by multiple search engines [0.03%]
一种基于多个搜索引擎的用于肽鉴定统一标准的方法：UniScore
Tsuyoshi Tabata,Akiyasu C Yoshizawa,Kosuke Ogata et al.
Tsuyoshi Tabata et al.
We propose UniScore as a metric for integrating and standardizing the outputs of multiple search engines in the analysis of data-dependent acquisition (DDA) data from LC/MS/MS-based bottom-up proteomics. UniScore is calculated from the anno...