The Proteome of Large or Small Extracellular Vesicles in Pig Seminal Plasma Differs, Defining Sources and Biological Functions [0.03%]
猪精浆中大外泌体和小外泌体蛋白组的区别定义了其来源及生物学功能
Isabel Barranco,Christian M Sanchez-López,Diego Bucci et al.
Isabel Barranco et al.
Seminal plasma contains many morphologically heterogeneous extracellular vesicles (sEVs). These are sequentially released by cells of the testis, epididymis, and accessory sex glands and involved in male and female reproductive processes. T...
Precision Neoantigen Discovery Using Large-Scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation [0.03%]
基于大规模免疫肽组和MHC肽呈递的复合建模发现精准 neo 抗原
Rachel Marty Pyke,Datta Mellacheruvu,Steven Dea et al.
Rachel Marty Pyke et al.
Major histocompatibility complex (MHC)-bound peptides that originate from tumor-specific genetic alterations, known as neoantigens, are an important class of anticancer therapeutic targets. Accurately predicting peptide presentation by MHC ...
Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins [0.03%]
多细胞系溶酶体蛋白质组分析揭示了独特的特征和新的溶酶体蛋白
Fatema Akter,Sara Bonini,Srigayatri Ponnaiyan et al.
Fatema Akter et al.
Lysosomes, the main degradative organelles of mammalian cells, play a key role in the regulation of metabolism. It is becoming more and more apparent that they are highly active, diverse, and involved in a large variety of processes. The es...
Profiling Humoral Immunity After Mixing and Matching COVID-19 Vaccines Using SARS-CoV-2 Variant Protein Microarrays [0.03%]
使用新冠病毒变异蛋白微阵列检测混合接种新冠疫苗后的体液免疫特征
Ho-Chang Kuo,Kuang-Che Kuo,Pin-Xian Du et al.
Ho-Chang Kuo et al.
In November 2022, 68% of the population received at least one dose of COVID-19 vaccines. Owing to the ongoing mutations, especially for the variants of concern (VOCs), it is important to monitor the humoral immune responses after different ...
Deep Proteome Profiling of White Adipose Tissue Reveals Marked Conservation and Distinct Features Between Different Anatomical Depots [0.03%]
深度蛋白质组学揭示白色脂肪组织在不同解剖部位中的显著保守性和独特性特征
Søren Madsen,Marin E Nelson,Vinita Deshpande et al.
Søren Madsen et al.
White adipose tissue is deposited mainly as subcutaneous adipose tissue (SAT), often associated with metabolic protection, and abdominal/visceral adipose tissue, which contributes to metabolic disease. To investigate the molecular underpinn...
Increasing Complexity of the N-Glycome During Caenorhabditis Development [0.03%]
秀丽杆线虫发育过程中N-聚糖的复杂性增加
Iain B H Wilson,Shi Yan,Chunsheng Jin et al.
Iain B H Wilson et al.
Caenorhabditis elegans is a frequently employed genetic model organism and has been the object of a wide range of developmental, genetic, proteomic, and glycomic studies. Here, using an off-line MALDI-TOF-MS approach, we have analyzed the N...
P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma [0.03%]
P300与N-Myc相互作用并通过改变其翻译后修饰来调节其蛋白稳定性的研究
Cheng Cheng,Tian He,Kai Chen et al.
Cheng Cheng et al.
MYCN amplification is an independent risk factor for poor prognosis in neuroblastoma (NB), but its protein product cannot be directly targeted because of protein structure. Thus, this study aimed to explore novel ways to indirectly target N...
Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia [0.03%]
DNA-PK和KIT信号通路在KIT突变的急性髓系白血病中的协同靶向作用
Heather C Murray,Kasey Miller,Joshua S Brzozowski et al.
Heather C Murray et al.
Acute myeloid leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases F...
O-Glycomic and Proteomic Signatures of Spontaneous and Butyrate-Stimulated Colorectal Cancer Cell Line Differentiation [0.03%]
自发性和丁酸刺激的结直肠癌细胞系分化的O-糖组学和蛋白质组学特征
K Madunić,Y M C A Luijkx,O A Mayboroda et al.
K Madunić et al.
Gut microbiota of the gastrointestinal tract provide health benefits to the human host via bacterial metabolites. Bacterial butyrate has beneficial effects on intestinal homeostasis and is the preferred energy source of intestinal epithelia...
Proteomic Discovery of Plasma Protein Biomarkers and Development of Models Predicting Prognosis of High-Grade Serous Ovarian Carcinoma [0.03%]
血浆蛋白质生物标志物的蛋白组学发现及高级别浆液性卵巢癌预后模型的构建
Se Ik Kim,Suhyun Hwangbo,Kisoon Dan et al.
Se Ik Kim et al.
Ovarian cancer is one of the most lethal female cancers. For accurate prognosis prediction, this study aimed to investigate novel, blood-based prognostic biomarkers for high-grade serous ovarian carcinoma (HGSOC) using mass spectrometry-bas...