Serum Proteomics Identifies Biomarkers Associated With the Pathogenesis of Idiopathic Pulmonary Fibrosis [0.03%]
血清蛋白质组学鉴定与特发性肺纤维化发病机制相关的生物标志物
Lan Wang,Minghui Zhu,Yan Li et al.
Lan Wang et al.
The heterogeneity of idiopathic pulmonary fibrosis (IPF) limits its diagnosis and treatment. The association between the pathophysiological features and the serum protein signatures of IPF currently remains unclear. The present study analyz...
Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates [0.03%]
脑脊液蛋白标志物指示SARS-CoV-2感染非人灵长类动物的神经损伤
Sudipa Maity,Meredith G Mayer,Qingbo Shu et al.
Sudipa Maity et al.
Neurologic manifestations are among the most frequently reported complications of COVID-19. However, given the paucity of tissue samples and the highly infectious nature of the etiologic agent of COVID-19, we have limited information to und...
Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain [0.03%]
鼠脑PKC_epsilon底物的化学遗传学识别
Michael P Dugan,Laura B Ferguson,Nicholas T Hertz et al.
Michael P Dugan et al.
PKC epsilon (PKCε) plays important roles in behavioral responses to alcohol and in anxiety-like behavior in rodents, making it a potential drug target for reducing alcohol consumption and anxiety. Identifying signals downstream of PKCε co...
cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria [0.03%]
CKMT1是蓝藻中铁氧还蛋白-NADP +氧化还原酶的赖氨酸甲基化酶，并调节能量转移
Gaoxiang Cao,Xiaohuang Lin,Mingtian Ling et al.
Gaoxiang Cao et al.
Lysine methylation is a conserved and dynamic regulatory posttranslational modification performed by lysine methyltransferases (KMTs). KMTs catalyze the transfer of mono-, di-, or tri-methyl groups to substrate proteins and play a critical ...
Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell [0.03%]
卵巢癌患者血清外泌体含LRP1并促进卵巢癌细胞迁移
Wei Zhou,Jiachen Ma,Han Zhao et al.
Wei Zhou et al.
Ovarian cancer is a gynecological tumor with extremely high mortality and poor prognosis. Exosomes derived from tumor cells contain abundant proteins that may influence tumor metastasis. The purpose of our study was to explore the proteomic...
Hannah Boekweg,Samuel H Payne
Hannah Boekweg
Single-cell proteomics is growing rapidly and has made several technological advancements. As most research has been focused on improving instrumentation and sample preparation methods, very little attention has been given to algorithms res...
Large-Scale Immunopeptidome Analysis Reveals Recurrent Posttranslational Splicing of Cancer- and Immune-Associated Genes [0.03%]
大规模免疫肽组分析揭示了癌症和免疫相关基因的转录后剪接现象
Ronen Levy,Tal Alter Regev,Wayne Paes et al.
Ronen Levy et al.
Posttranslational spliced peptides (PTSPs) are a unique class of peptides that have been found to be presented by HLA class-I molecules in cancer. Thus far, no consensus has been reached on the proportion of PTSPs in the immunopeptidome, wi...
Proteomic Characterization of Acute Myeloid Leukemia for Precision Medicine [0.03%]
急性髓系白血病的蛋白质组特征分析助力精准医疗
Pedro Casado,Pedro R Cutillas
Pedro Casado
Acute myeloid leukemia (AML) is a highly heterogeneous cancer of the hematopoietic system with no cure for most patients. In addition to chemotherapy, treatment options for AML include recently approved therapies that target proteins with r...
Comprehensive Proteomics Analysis Identifies CD38-Mediated NAD+ Decline Orchestrating Renal Fibrosis in Pediatric Patients With Obstructive Nephropathy [0.03%]
全面蛋白质组学分析鉴定出CD38介导的NAD+下降在儿童梗阻性肾病患者中调控肾纤维化的作用
Yuandong Tao,Jifeng Wang,Xuexue Lyu et al.
Yuandong Tao et al.
Obstructive nephropathy is one of the leading causes of kidney injury and renal fibrosis in pediatric patients. Although considerable advances have been made in understanding the pathophysiology of obstructive nephropathy, most of them were...
Benchmarking Bioinformatics Pipelines in Data-Independent Acquisition Mass Spectrometry for Immunopeptidomics [0.03%]
数据非依赖性采集质谱在免疫肽组学中的生物信息学管道基准测试
Mohammad Shahbazy,Sri H Ramarathinam,Patricia T Illing et al.
Mohammad Shahbazy et al.
Immunopeptidomes are the peptide repertoires bound by the molecules encoded by the major histocompatibility complex [human leukocyte antigen (HLA) in humans]. These HLA-peptide complexes are presented on the cell surface for immune T-cell r...