Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets [0.03%]
亨廷顿舞蹈病中棘神经元蛋白质组学分析发现脂滴发生改变
Kizito-Tshitoko Tshilenge,Carlos Galicia Aguirre,Joanna Bons et al.
Kizito-Tshitoko Tshilenge et al.
Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the function of the HTT protein. Although HTT is expressed in different...
Bioinertization of NanoLC/MS/MS Systems by Depleting Metal Ions From the Mobile Phases for Phosphoproteomics [0.03%]
通过从流动相中耗尽金属离子对nanoLC / MS / MS系统进行生物惰性处理用于磷酸蛋白质组学研究
Yumi Komori,Tomoya Niinae,Koshi Imami et al.
Yumi Komori et al.
We have successfully developed a bioinertized nanoflow LC/MS/MS (nanoLC/MS/MS) system for the highly sensitive analysis of phosphopeptides by depleting metal ions from the mobile phase. We found that not only direct contact of phosphopeptid...
Development of a Spectral Library for the Discovery of Altered Genomic Events in Mycobacterium avium Associated With Virulence Using Mass Spectrometry-Based Proteogenomic Analysis [0.03%]
基于质谱的蛋白质基因组学分析在发现鸟分枝杆菌与毒力相关的基因组改变事件中的光谱库构建
Chinmaya Narayana Kotimoole,Neelam Antil,Sandeep Kasaragod et al.
Chinmaya Narayana Kotimoole et al.
Mycobacterium avium is one of the prominent disease-causing bacteria in humans. It causes lymphadenitis, chronic and extrapulmonary, and disseminated infections in adults, children, and immunocompromised patients. M. avium has ∼4500 predic...
Phenotypic Heterogeneity Analysis of APC-Mutant Colon Cancer by Proteomics and Phosphoproteomics Identifies RAI14 as a Key Prognostic Determinant in East Asians and Westerners [0.03%]
基于蛋白质组和磷酸化蛋白质组的APC突变结直肠癌表型异质性分析鉴定出在亚裔人和西方人在预后中起关键作用的RAI14基因
Rou Zhang,Meng Hu,Hai-Ning Chen et al.
Rou Zhang et al.
Adenomatous polyposis coli (APC) is an important tumor suppressor and is mostly linked to the regulation of the Wnt/β-catenin signaling pathway. APC mutation has been identified as an early event in more than 80% of sporadic colorectal can...
PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer [0.03%]
结直肠癌中PI3Kα移位介导核内磷脂酸(3,4,5)P3效应器信号转导
Michelle Palmieri,Bruno Catimel,Dmitri Mouradov et al.
Michelle Palmieri et al.
The canonical view of PI3Kα signaling describes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) generation and activation of downstream effectors at the plasma membrane or at microtubule-bound endosomes. Here, we show that color...
Ten Years of Extracellular Matrix Proteomics: Accomplishments, Challenges, and Future Perspectives [0.03%]
细胞外基质蛋白质组学的十年：成就、挑战与未来展望
Alexandra Naba
Alexandra Naba
The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the architectural scaffold of multicellular organisms. In addition to its structural role, the ECM conveys signals orchestrating cellular phenotypes. Alter...
Corrigendum for "Quantitative Proteomics Identifies Proteins Enriched in Large and Small Extracellular Vesicles" [0.03%]
“定量蛋白组学鉴定大型和小型细胞外囊泡中富集的蛋白质”的勘误表
Anna Lischnig,Markus Bergqvist,Takahiro Ochiya et al.
Anna Lischnig et al.
Characterization of p38α Signaling Networks in Cancer Cells Using Quantitative Proteomics and Phosphoproteomics [0.03%]
基于定量磷酸化蛋白质组学的p38α信号转导网络的表征研究癌症细胞中的p38α信号转导网络
Yuzhen Dan,Nevenka Radic,Marina Gay et al.
Yuzhen Dan et al.
p38α (encoded by MAPK14) is a protein kinase that regulates cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates many substrates both in the cytoplasm and nucleus, allowi...
Integrated MicroRNA and Secretome Analysis of Human Endometrial Organoids Reveal the miR-3194-5p/Aquaporin/S100A9 Module in Regulating Trophoblast Functions [0.03%]
人子宫类器官的整合microRNA和分泌组分析揭示了miR-3194-5p/AQP/S100A9模块在调节滋养细胞功能中的作用
Yang Dong,Jianlin Li,Dandan Cao et al.
Yang Dong et al.
Successful placentation requires delicate communication between the endometrium and trophoblasts. The invasion and integration of trophoblasts into the endometrium during early pregnancy are crucial to placentation. Dysregulation of these f...
Cold Exposure-induced Alterations in the Brain Peptidome and Gut Microbiome Are Linked to Energy Homeostasis in Mice [0.03%]
冷暴露诱导的小鼠大脑肽组和肠道微生物群的改变与能量稳态有关
Xue Wang,Qianqian Wang,Mingxin Zhao et al.
Xue Wang et al.
Energy homeostasis of mammals during cold exposure involves complicated neural regulation and is affected by gut microbiota. However, the regulatory mechanism remains unclear partially due to a lack of comprehensive knowledge of the signali...