Translational and Posttranslational Dynamics in a Model Peptidergic System [0.03%]
模型肽能系统中的转录后和翻译后动力学研究
Soledad Bárez-López,André S Mecawi,Natasha Bryan et al.
Soledad Bárez-López et al.
The cell bodies of hypothalamic magnocellular neurones are densely packed in the hypothalamic supraoptic nucleus, whereas their axons project to the anatomically discrete posterior pituitary gland. We have taken advantage of this unique ana...
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection [0.03%]
兴奋毒性过程中神经元N-末端变化揭示与突触功能障碍相关的蛋白水解事件及潜在的神经保护作用靶点
S Sadia Ameen,Nane Griem-Krey,Antoine Dufour et al.
S Sadia Ameen et al.
Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicit...
Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease [0.03%]
整合蛋白质组学揭示神经素(NRN1)作为阿尔茨海默病认知适应力介质的作用机制
Cheyenne Hurst,Derian A Pugh,Measho H Abreha et al.
Cheyenne Hurst et al.
The molecular mechanisms and pathways enabling certain individuals to remain cognitively normal despite high levels of Alzheimer's disease (AD) pathology remain incompletely understood. These cognitively normal people with AD pathology are ...
Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP [0.03%]
定量蛋白组学分析揭示了apoE4依赖的调节肌动蛋白蛋白质VASP的磷酸化状态
Zeynep Cakir,Samuel J Lord,Yuan Zhou et al.
Zeynep Cakir et al.
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease. While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress...
Integrative Proteomics and N-Glycoproteomics Analyses of Rheumatoid Arthritis Synovium Reveal Immune-Associated Glycopeptides [0.03%]
整合蛋白组和N-糖蛋白组分析揭示类风湿关节炎滑膜中免疫相关糖肽
Zhiqiang Xu,Yi Liu,Siyu He et al.
Zhiqiang Xu et al.
Rheumatoid arthritis (RA) is a typical autoimmune disease characterized by synovial inflammation, synovial tissue hyperplasia, and destruction of bone and cartilage. Protein glycosylation plays key roles in the pathogenesis of RA but in-dep...
Withdrawal of 'Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation' [0.03%]
“利用大规模免疫肽组和MHC肽呈递的综合模型进行精确neo抗原发现”一文撤稿通知
Rachel Marty Pyke,Dattatreya Mellacheruvu,Steven Dea et al.
Rachel Marty Pyke et al.
Retraction of Publication
Molecular & cellular proteomics : MCP. 2023 Apr;22(4):100511. DOI:10.1016/j.mcpro.2023.100511 2023
MSFragger-Labile: A Flexible Method to Improve Labile PTM Analysis in Proteomics [0.03%]
灵活提高蛋白质组学中不稳定的PTM分析的方法：MSFragger-易变性
Daniel A Polasky,Daniel J Geiszler,Fengchao Yu et al.
Daniel A Polasky et al.
Posttranslational modifications of proteins play essential roles in defining and regulating the functions of the proteins they decorate, making identification of these modifications critical to understanding biology and disease. Methods for...
Changes of Development from Childhood to Late Adulthood in Rats Tracked by Urinary Proteome [0.03%]
基于尿蛋白组变化解析大鼠从幼儿到晚年的发育规律
Xuanzhen Pan,Yongtao Liu,Yijin Bao et al.
Xuanzhen Pan et al.
To date, studies of development have mainly focused on the embryonic stage and a short time thereafter. There has been little research on the whole life of an individual from childhood to aging and death. For the first time, we used noninva...
SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells [0.03%]
新冠病毒变异体在奥密克戎感染细胞中显示出不同的宿主细胞蛋白质组谱型及延迟的免疫反应激活迹象
Melinda Metzler,Rebecca George Tharyan,Kevin Klann et al.
Melinda Metzler et al.
The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host ...
Data-Independent Acquisition Phosphoproteomics of Urinary Extracellular Vesicles Enables Renal Cell Carcinoma Grade Differentiation [0.03%]
数据非依赖性获取的尿液外泌体磷酸蛋白质组学可实现肾细胞癌分级区分
Marco Hadisurya,Zheng-Chi Lee,Zhuojun Luo et al.
Marco Hadisurya et al.
Translating the research capability and knowledge in cancer signaling into clinical settings has been slow and ineffective. Recently, extracellular vesicles (EVs) have emerged as a promising source for developing disease phosphoprotein mark...