Ultrasensitive Protein Detection Technologies for Extracellular Vesicle Measurements [0.03%]
超灵敏蛋白质检测技术在外泌体测量中的应用
Adnan Shami-Shah,Maia Norman,David R Walt
Adnan Shami-Shah
Extracellular vesicles (EVs) are nanoscopic, heterogenous, lipid-rich particles that carry a multitude of cargo biomolecules including proteins, nucleic acids, and metabolites. Although historically EVs were regarded as cellular debris with...
Germ Cell-Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive Azoospermia [0.03%]
AZoS单位干细胞特异性蛋白AKAP4和ASPY有助于非阻塞性无精子症罕见精子的识别
Junyan Zhang,Mirzo Kanoatov,Keith Jarvi et al.
Junyan Zhang et al.
Non-obstructive azoospermia (NOA), the most severe form of male infertility, could be treated with intracytoplasmic sperm injection, providing spermatozoa were retrieved with the microdissection testicular sperm extraction (mTESE). We hypot...
Proteome Dynamics During Transition From Exponential to Stationary Phase Under Aerobic and Anaerobic Conditions in Yeast [0.03%]
酵母在需氧和厌氧条件下从指数期到稳定期过渡期间的蛋白质组动力学
Maxime den Ridder,Wiebeke van den Brandeler,Meryem Altiner et al.
Maxime den Ridder et al.
The yeast Saccharomyces cerevisiae is a widely-used eukaryotic model organism and a promising cell factory for industry. However, despite decades of research, the regulation of its metabolism is not yet fully understood, and its complexity ...
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer [0.03%]
硫康唑通过触发氧化应激和抑制糖酵解诱导PANoptosis以增加食管癌的放射敏感性
Lu-Xin Liu,Jing-Hua Heng,Dan-Xia Deng et al.
Lu-Xin Liu et al.
Esophageal cancer is the seventh most common cancer in the world. Although traditional treatment methods such as radiotherapy and chemotherapy have good effects, their side effects and drug resistance remain problematic. The repositioning o...
The Proteome and Phosphoproteome Uncovers Candidate Proteins Associated With Vacuolar Phosphate Signal Multipled by Vacuolar Phosphate Transporter 1 (VPT1) in Arabidopsis [0.03%]
拟南芥中由 vacuolar phosphate transporter 1（VPT1）倍增的液泡磷酸盐信号的蛋白质组和磷酸化蛋白质组揭示了候选蛋白
Yanjun Zhang,Xuexue Chen,Jinjing Feng et al.
Yanjun Zhang et al.
Plant vacuoles serve as the primary intracellular compartments for inorganic phosphate (Pi) storage. Passage of Pi across vacuolar membranes plays a critical role in buffering the cytoplasmic Pi level against fluctuations of external Pi and...
Proteomics: Progress and Promise of High-Throughput Proteomics in Chronic Kidney Disease [0.03%]
慢性肾脏病高通量蛋白质组学研究的进展与展望
Pascal Schlosser,Morgan E Grams,Eugene P Rhee
Pascal Schlosser
Current proteomic tools permit the high-throughput analysis of the blood proteome in large cohorts, including those enriched for chronic kidney disease (CKD) or its risk factors. To date, these studies have identified numerous proteins asso...
Cellular Proteomic Profiling Using Proximity Labeling by TurboID-NES in Microglial and Neuronal Cell Lines [0.03%]
利用TurboID-NES邻近标记进行微胶质细胞和神经元细胞系的蛋白质组学分析
Sydney Sunna,Christine Bowen,Hollis Zeng et al.
Sydney Sunna et al.
Different brain cell types play distinct roles in brain development and disease. Molecular characterization of cell-specific mechanisms using cell type-specific approaches at the protein (proteomic) level can provide biological and therapeu...
Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas [0.03%]
肿瘤间质液中的生物标志物可能有助于解释角质细胞癌之间的不同行为
Clara Matas-Nadal,Joan J Bech-Serra,Sònia Gatius et al.
Clara Matas-Nadal et al.
Basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (SCCs) are the most frequent types of cancer, and both originate from the keratinocyte transformation, giving rise to the group of tumors called keratinocyte carcinomas (KC...
Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control [0.03%]
泛素组分析揭示了UBE2D3在体内的作用底物并表明UBE2D3参与蛋白质质量控制
Zeliha Yalçin,Daniëlle Koot,Karel Bezstarosti et al.
Zeliha Yalçin et al.
Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ub...
Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics [0.03%]
结直肠癌组学及磷酸化组学揭示GSK3α的临床意义及激酶功能
Li Gao,Ying Lu,Hai-Ning Chen et al.
Li Gao et al.
GSK3α and GSK3β are two GSK3 isoforms with 84% overall identity and 98% identity in their catalytic domains. GSK3β plays important roles in the pathogenesis of cancer, while GSK3α has long been considered a functionally redundant protei...