Proteomics Profiling Reveals the Molecular Signatures and Potential Therapeutic Targets of Human Nasopharyngeal Carcinoma [0.03%]
蛋白质组学谱型分析揭示鼻咽癌的分子标志及潜在治疗靶点
Ying Fu,Xujun Liang,Xinming Yang et al.
Ying Fu et al.
Nasopharyngeal carcinoma (NPC), a malignant tumor distinctly characterized by ethnic and geographic distribution, is highly prevalent in Southern China and Southeast Asia. However, the molecular mechanisms of NPC have not been fully reveale...
Yuri van der Burgt,Manfred Wuhrer
Yuri van der Burgt
Glycoproteomics reveals site-specific O- and N-glycosylation that may influence protein properties including binding, activity, and half-life. The increasingly mature toolbox with glycomic and glycoproteomic strategies is applied for the de...
Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate [0.03%]
降解组学鉴定膜型基质金属蛋白酶-1为ADAMTS9和ADAMTS20的底物
Sumeda Nandadasa,Daniel Martin,Gauravi Deshpande et al.
Sumeda Nandadasa et al.
The secreted metalloproteases ADAMTS9 and ADAMTS20 are implicated in extracellular matrix proteolysis and primary cilium biogenesis. Here, we show that clonal gene-edited RPE-1 cells in which ADAMTS9 was inactivated, and which constitutivel...
STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis [0.03%]
STK33通过磷酸化顶体后期纤维鞘中的AKAP3/4调控精子鞭毛的形成
Weiling Yu,Yang Li,Hong Chen et al.
Weiling Yu et al.
Spermatogenesis defects are important for male infertility; however, the etiology and pathogenesis are still unknown. Herein, we identified two loss-of-function mutations of STK33 in seven individuals with non-obstructive azoospermia. Furth...
Sensitive, High-Throughput HLA-I and HLA-II Immunopeptidomics Using Parallel Accumulation-Serial Fragmentation Mass Spectrometry [0.03%]
使用平行累积-顺序片段化质谱的敏感且高通量的HLA-I和HLA-II免疫肽组学分析
Kshiti Meera Phulphagar,Claudia Ctortecka,Alvaro Sebastian Vaca Jacome et al.
Kshiti Meera Phulphagar et al.
Comprehensive and in-depth identification of the human leukocyte antigen class I (HLA-I) and class II (HLA-II) tumor immunopeptidome can inform the development of cancer immunotherapies. Mass spectrometry (MS) is a powerful technology for d...
Robust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices With Zeno SWATH Data-Independent Acquisition [0.03%]
基于Zeno-SWATH数据非依赖性采集的食蟹猴及人样本分析型流水线质谱蛋白质组学研究
Weiwen Sun,Yuan Lin,Yue Huang et al.
Weiwen Sun et al.
Modern mass spectrometers routinely allow deep proteome coverage in a single experiment. These methods are typically operated at nanoflow and microflow regimes, but they often lack throughput and chromatographic robustness, which is critica...
Investigation of Cellular Response to the HSP90 Inhibition in Human Cells Through Thermal Proteome Profiling [0.03%]
热稳定性蛋白组学特征鉴别HSP90抑制的细胞作用靶点
Kejun Yin,Ronghu Wu
Kejun Yin
Heat shock proteins are chaperones, and they are responsible for protein folding in cells. Heat shock protein 90 (HSP90) is one of the most important chaperones in human cells, and its inhibition is promising for cancer therapy. However, de...
Mohan Babu,Michael Snyder
Mohan Babu
The world has witnessed a steady rise in both non-infectious and infectious chronic diseases, prompting a cross-disciplinary approach to understand and treating disease. Current medical care focuses on treating people after they become pati...
MsImpute: Estimation of Missing Peptide Intensity Data in Label-Free Quantitative Mass Spectrometry [0.03%]
基于无标签定量质谱法的缺失肽段强度数据估算方法MsImpute:
Soroor Hediyeh-Zadeh,Andrew I Webb,Melissa J Davis
Soroor Hediyeh-Zadeh
Mass spectrometry (MS) enables high-throughput identification and quantification of proteins in complex biological samples and can provide insights into the global function of biological systems. Label-free quantification is cost-effective ...
Meeting Report on the 2nd Chinese American Society for Mass Spectrometry Conference: Advancing Biological and Pharmaceutical Mass Spectrometry [0.03%]
第二届中美质谱大会报告会——推动生物和药物分析质谱技术的发展会议纪要
Yue Chen,Ying Ge,Xianlin Han et al.
Yue Chen et al.
The 2nd CASMS conference was held virtually through Gather. Town platform from October 17 to 21, 2022, with a total of 363 registrants including an outstanding and diverse group of scientists at the forefront of their research fields from b...