Parallel Proteomic Comparison of Mutants With Altered Carbon Metabolism Reveals Hik8 Regulation of PII Phosphorylation and Glycogen Accumulation in a Cyanobacterium [0.03%]
平行蛋白质分析碳代谢异常的突变体揭示了藻蓝菌中Hik8对PII磷酸化和糖原积累的调节作用
Chengcheng Huang,Xiaoxiao Duan,Haitao Ge et al.
Chengcheng Huang et al.
Carbon metabolism is central to photosynthetic organisms and involves the coordinated operation and regulation of numerous proteins. In cyanobacteria, proteins involved in carbon metabolism are regulated by multiple regulators including the...
Accurate Label-Free Quantification by directLFQ to Compare Unlimited Numbers of Proteomes [0.03%]
一种可同时比较任意数量蛋白质组的直接Label-Free定量新方法直接LFQ
Constantin Ammar,Julia Patricia Schessner,Sander Willems et al.
Constantin Ammar et al.
Recent advances in mass spectrometry-based proteomics enable the acquisition of increasingly large datasets within relatively short times, which exposes bottlenecks in the bioinformatics pipeline. Although peptide identification is already ...
A New Cellular Interactome of SARS-CoV-2 Nucleocapsid Protein and Its Biological Implications [0.03%]
SARS-CoV-2核衣壳蛋白新的细胞相互作用图谱及其生物学意义
Yuan-Qin Min,Mengzhuo Huang,Kuan Feng et al.
Yuan-Qin Min et al.
There is still much to uncover regarding the molecular details of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. As the most abundant protein, coronavirus nucleocapsid (N) protein encapsidates viral RNAs, serving as...
Large-Scale Plasma Proteome Epitome Profiling is an Efficient Tool for the Discovery of Cancer Biomarkers [0.03%]
基于血浆蛋白质组抗原表位的大型队列研究是癌症标志物发现的有效工具
Jozsef Lazar,Peter Antal-Szalmas,Istvan Kurucz et al.
Jozsef Lazar et al.
Current proteomic technologies focus on the quantification of protein levels, while little effort is dedicated to the development of system approaches to simultaneously monitor proteome variability and abundance. Protein variants may displa...
Peiwu Huang,Weina Gao,Changying Fu et al.
Peiwu Huang et al.
Pancreatic cancer, in most cases being pancreatic ductal adenocarcinoma (PDAC), is one of the most lethal cancers with a median survival time of less than 6 months. Therapeutic options are very limited for patients with PDAC, and surgery is...
Jakob M Bader,Vincent Albrecht,Matthias Mann
Jakob M Bader
Accurate biomarkers are a crucial and necessary precondition for precision medicine, yet existing ones are often unspecific and new ones have been very slow to enter the clinic. Mass spectrometry (MS)-based proteomics excels by its untarget...
In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus-Related Liver Diseases [0.03%]
深入的血清蛋白质组学揭示了乙型肝炎病毒相关肝脏疾病中癌症标志物的发展轨迹
Meng Xu,Kaikun Xu,Shangqi Yin et al.
Meng Xu et al.
Hepatocellular carcinoma (HCC) is a prevalent cancer in China, with chronic hepatitis B (CHB) and liver cirrhosis (LC) being high-risk factors for developing HCC. Here, we determined the serum proteomes (762 proteins) of 125 healthy control...
Mass Spectrometry-Based Proteomics of Epithelial Ovarian Cancers: A Clinical Perspective [0.03%]
基于质谱的上皮卵巢癌蛋白质组学：临床视角
Liujia Qian,Rui Sun,Zhangzhi Xue et al.
Liujia Qian et al.
Increasing proteomic studies focused on epithelial ovarian cancer (EOC) have attempted to identify early disease biomarkers, establish molecular stratification, and discover novel druggable targets. Here we review these recent studies from ...
Jessica L Moore,Nathan Heath Patterson,Jeremy L Norris et al.
Jessica L Moore et al.
Imaging mass spectrometry (IMS) is a molecular technology utilized for spatially driven research, providing molecular maps from tissue sections. This article reviews matrix-assisted laser desorption ionization (MALDI) IMS and its progress a...
An Inflection Point in Cancer Protein Biomarkers: What was and What's Next [0.03%]
癌症蛋白生物标志物的转折点：从过去到现在及未来
Anna D Barker,Mario M Alba,Parag Mallick et al.
Anna D Barker et al.
Biomarkers remain the highest value proposition in cancer medicine today-especially protein biomarkers. Despite decades of evolving regulatory frameworks to facilitate the review of emerging technologies, biomarkers have been mostly about p...