An Integrated Approach to Protein Discovery and Detection From Complex Biofluids [0.03%]
复杂生物液体中蛋白质的发现与检测集成方法学研究
Gordon T Luu,Chang Ge,Yisha Tang et al.
Gordon T Luu et al.
Ovarian cancer, a leading cause of cancer-related deaths among women, has been notoriously difficult to screen for and diagnose early, as early detection significantly improves survival. Researchers and clinicians seek routinely usable and ...
SpotLight Proteomics Identifies Variable Sequences of Blood Antibodies Specific Against Deamidated Human Serum Albumin [0.03%]
SpotLight蛋白质组学鉴定出针对脱酰胺人血清白蛋白的血液抗体中的可变序列
Jijing Wang,Susanna L Lundström,Weiqi Lu et al.
Jijing Wang et al.
Spontaneous deamidation of asparaginyl residues in proteins, if not repaired or cleared, can set in motion a cascade that leads to deteriorated health. Previously, we have discovered that deamidated human serum albumin (HSA) is elevated in ...
A Peptidisc-Based Survey of the Plasma Membrane Proteome of a Mammalian Cell [0.03%]
基于Peptidisc的哺乳动物细胞质膜蛋白质组研究
Zhiyu Zhao,Arshdeep Khurana,Frank Antony et al.
Zhiyu Zhao et al.
Membrane proteins play critical roles at the cell surface and their misfunction is a hallmark of many human diseases. A precise evaluation of the plasma membrane proteome is therefore essential for cell biology and for discovering novel bio...
Functional Impact of Protein-RNA Variation in Clinical Cancer Analyses [0.03%]
临床癌症分析中蛋白质-RNA变异的功能影响
Gali Arad,Tamar Geiger
Gali Arad
Comprehensive molecular characterization of tumors aims to uncover cancer vulnerabilities, drug resistance mechanisms, and biomarkers. Identification of cancer drivers was suggested as the basis for patient-tailored therapy, and transcripto...
Remembering Ad de Jong [0.03%]
忆阿德·德容
Cécile A C M van Els,Peter A van Veelen,Albert J R Heck et al.
Cécile A C M van Els et al.
Corrigendum for "Mass Spectrometry-Based Proteomics Analysis of Human Substantia Nigra From Parkinson's Disease Patients Identifies Multiple Pathways Potentially Involved in the Disease" [0.03%]
关于“基于质谱的蛋白质组学分析帕金森病患者黑质中多个可能参与疾病进程的通路”的勘误通知
Yura Jang,Olga Pletnikova,Juan C Troncoso et al.
Yura Jang et al.
Comprehensive Glycoprofiling of Oral Tumors Associates N-Glycosylation With Lymph Node Metastasis and Patient Survival [0.03%]
全面分析口腔肿瘤glycome，发现N-糖基化与淋巴结转移和患者生存期有关
Carolina Moretto Carnielli,Thayná Melo de Lima Morais,Fábio Malta de Sá Patroni et al.
Carolina Moretto Carnielli et al.
While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), the heterogeneous and dynamic glycoproteome of tumor tissues from OSCC patients remain unmapped. To this end, we here employ an integrated multi...
Proteogenomic Features of the Highly Polymorphic Histidine-rich Glycoprotein Arose Late in Evolution [0.03%]
多态性丰富的组氨酸丰富糖蛋白的蛋白质基因组特征在进化过程中出现较晚
Yang Zou,Bas van Breukelen,Matti Pronker et al.
Yang Zou et al.
Histidine-rich glycoprotein (HRG) is a liver-produced protein circulating in human serum at high concentrations of around 125 μg/ml. HRG belongs to the family of type-3 cystatins and has been implicated in a plethora of biological processe...
In-Depth Characterization of Apoptosis N-Terminome Reveals a Link Between Caspase-3 Cleavage and Posttranslational N-Terminal Acetylation [0.03%]
凋亡N末端组学的深入表征揭示了caspase-3切割与翻译后N端乙酰化之间的联系
Rawad Hanna,Andrey Rozenberg,Layla Saied et al.
Rawad Hanna et al.
The N termini of proteins contain information about their biochemical properties and functions. These N termini can be processed by proteases and can undergo other co- or posttranslational modifications. We have developed LATE (LysN Amino T...
pepDESC: A Method for the Detection of Differentially Expressed Proteins for Mass Spectrometry-Based Single-Cell Proteomics Using Peptide-level Information [0.03%]
基于肽水平信息的质谱单细胞蛋白质组学差异表达蛋白鉴定方法PEPDESC
Yutong Zhang
Yutong Zhang
Single-cell proteomics as an emerging field has exhibited potential in revealing cellular heterogeneity at the functional level. However, accurate interpretation of single-cell proteomics data suffers from challenges such as measurement noi...