Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma [0.03%]
人肝细胞癌和肝内胆管癌的蛋白质组景观
Xiao Yi,Jiang Zhu,Wei Liu et al.
Xiao Yi et al.
Liver cancer is among the top leading causes of cancer mortality worldwide. Particularly, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA) have been extensively investigated from the aspect of tumor biology. However,...
Blood- and Urine-Based Liquid Biopsy for Early-Stage Cancer Investigation: Taken Clear Renal Cell Carcinoma as a Model [0.03%]
基于血液和尿液的液体活检在早期癌症检测中的应用——以透明细胞肾癌为例
Xiaoyan Liu,Mingxin Zhang,Chen Shao et al.
Xiaoyan Liu et al.
Liquid biopsy is a noninvasive technique that can provide valuable information for disease characterization by using biofluids as a source of biomarkers. Proteins found in biofluids can offer a wealth of information for understanding pathol...
Michael Y Mi,Jacob L Barber,Prashant Rao et al.
Michael Y Mi et al.
Regular exercise has many favorable effects on human health, which may be mediated in part by the release of circulating bioactive factors during each bout of exercise. Limited data exist regarding the kinetic responses of plasma proteins d...
Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein [0.03%]
交联质谱揭示高密度脂蛋白与SARS-CoV-2刺突糖蛋白之间的相互作用
Sean A Burnap,Ana Maria Ortega-Prieto,Jose M Jimenez-Guardeño et al.
Sean A Burnap et al.
High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the l...
Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets [0.03%]
乳腺癌细胞系的蛋白质组动力学鉴定出潜在的治疗性蛋白靶点
Rui Sun,Weigang Ge,Yi Zhu et al.
Rui Sun et al.
Treatment and relevant targets for breast cancer (BC) remain limited, especially for triple-negative BC (TNBC). We identified 6091 proteins of 76 human BC cell lines using data-independent acquisition (DIA). Integrating our proteomic findin...
Elucidating Fibroblast Growth Factor-Induced Kinome Dynamics Using Targeted Mass Spectrometry and Dynamic Modeling [0.03%]
基于靶向质谱和动态模型的成纤维细胞生长因子诱导的激酶组动力学研究
Tim S Veth,Chiara Francavilla,Albert J R Heck et al.
Tim S Veth et al.
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that, activated by their ligands, elicit a wide range of health and disease-related processes, such as cell proliferation and the epithelial-to-mesenchymal trans...
Proteome Mapping of the Human Pancreatic Islet Microenvironment Reveals Endocrine-Exocrine Signaling Sphere of Influence [0.03%]
人类胰岛微环境的蛋白质组定位测绘揭示内分泌-外分泌信号效应区
Sara J C Gosline,Marija Veličković,James C Pino et al.
Sara J C Gosline et al.
The need for a clinically accessible method with the ability to match protein activity within heterogeneous tissues is currently unmet by existing technologies. Our proteomics sample preparation platform, named microPOTS (Microdroplet Proce...
In-Depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-Glycoproteomic Impact of an Amish-Enriched Cardioprotective Variant in B4GALT1 [0.03%]
深入的质谱分析揭示了阿米什富集的心脏保护变异体B4GALT1对血浆蛋白质组和N-糖蛋白的影响
Yunlong Zhao,Shruti Nayak,Shivkumar Raidas et al.
Yunlong Zhao et al.
B4GALT1 encodes β-1,4-galactosyltransferase 1, an enzyme that plays a major role in glycan synthesis in the Golgi apparatus by catalyzing the addition of terminal galactose. Studies increasingly suggest that B4GALT1 may be involved in the ...
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin [0.03%]
异戊二烯化PALM2通过激活Ezrin促进食管鳞状细胞癌的转移
Dan-Xia Deng,Cheng-Yu Li,Zhen-Yuan Zheng et al.
Dan-Xia Deng et al.
Proteins containing a CAAX motif at the C-terminus undergo prenylation for localization and activity and include a series of key regulatory proteins, such as RAS superfamily members, heterotrimeric G proteins, nuclear lamina protein, and se...
UniProt and Mass Spectrometry-Based Proteomics-A 2-Way Working Relationship [0.03%]
UniProt与基于质谱的蛋白质组学之间的双向协作关系
E H Bowler-Barnett,J Fan,J Luo et al.
E H Bowler-Barnett et al.
The human proteome comprises of all of the proteins produced by the sequences translated from the human genome with additional modifications in both sequence and function caused by nonsynonymous variants and posttranslational modifications ...