Surfaceome Capture by Multiplex biotinylation (SUCAM) enables enhanced identification of cell surface proteins by mass spectrometry [0.03%]
基于多重复合生物素标记的表面组捕获技术可增强细胞表面蛋白质谱鉴定能力
Ana Levi,Tommy Shields,Irbaz I Badshah et al.
Ana Levi et al.
A key goal of surfaceomic discovery technologies is to comprehensively interrogate the cell surface proteome to identify targets for immunotherapy development. Considerable progress has made in the application of surfaceomics to profile can...
In Depth Characterization of the Promoter Proximal Proteome of Single Copy Locus FOXP2 [0.03%]
FOXP2单拷贝位点的邻近蛋白组的深入表征
Tim M G MacKenzie,Lucia Ramirez,Ruiqi Jian et al.
Tim M G MacKenzie et al.
Identifying the proteins that interact with sequence-defined chromatin segments is a critical step in understanding gene expression. Most procedures perform bulk analysis of samples to identify the general interactions that occur in a cellu...
Shireen S Al-Momani,Kerry Rambsbottom,Andrew Collins et al.
Shireen S Al-Momani et al.
SUMOylation is an understudied post-translational modification (PTM) linked to diverse physiological and pathological processes. Advances in enrichment strategies, combined with mass spectrometry (MS), have enabled large-scale mapping of SU...
Proteomic Profiling Reveals How Physiological Media Reshape Cancer Cell Proteomes and Signaling Networks [0.03%]
蛋白质组分析揭示生理培养基如何重塑癌细胞蛋白质组及信号网络
Colin Zenge,Brittany Q Pham,Kihong Nam et al.
Colin Zenge et al.
Altered metabolism is a hallmark of cancer, making metabolic enzymes attractive therapeutic targets. However, metabolic inhibitors have shown limited clinical success, partly due to differences between standard culture media and physiologic...
Plasma proteomic profiling was used to discover a biochemical recurrence prediction model for prostate cancer [0.03%]
应用血浆蛋白质组分析发现前列腺癌生化复发预测模型
Ning Xu,Linhui Zhang,Zhenmei Yao et al.
Ning Xu et al.
Prostate cancer (PCa) is one of the most common malignancies in men. There is limited data available regarding potential minimally-invasive biomarkers for predicting PCa outcomes and disease monitoring. Here, we investigate the proteomic pr...
Nickolas P Fisher,Vijaya Lakshmi Kanchustambham,Elizabeth L Tsui et al.
Nickolas P Fisher et al.
Ovarian tissue cryopreservation (OTC) is a fertility preservation strategy available to prepubertal patients undergoing gonadotoxic treatment who are at risk of developing premature ovarian insufficiency or for those whose treatment cannot ...
Deciphering membrane protein complexes in Plasmodium falciparum gametocytes via integrative structural systems biology [0.03%]
整合结构系统生物学在解码恶性疟原虫配子体膜蛋白复合物中的应用
Siavash Mostafavi,Valentin Maurer,Max Ruwolt et al.
Siavash Mostafavi et al.
Malaria is caused by protozoan parasites of the genus Plasmodium, that proliferate asexually in human erythrocytes. During each replication cycle, a small fraction of the parasites differentiates into gametocytes. These sexual gametocytes a...
Expanding the Global Map of Protein Post Translational Modifications with Immunoaffinity Enrichment and nDIA Analysis on the Orbitrap Astral Mass Spectrometer [0.03%]
基于轨道离子阱Astral质谱仪免疫亲和富集与nDIA分析的蛋白质翻译后修饰图谱研究
Mukesh Kumar,Anthony P Possemato,Barry M Zee et al.
Mukesh Kumar et al.
Post-translational modifications (PTMs) contribute greatly to the diversity of the human proteome by affecting protein structure, function, interactions, stability, localization, and more. The study of PTMs is essential to understand variou...
Lactylome Reprogramming Mediates Therapeutic Response and Adaptation to Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma [0.03%]
丙酮酸乳酸转移酶组蛋白乳酰化介导食管鳞癌新辅助化疗的治疗反应及耐药机制研究
Panpan Peng,Xinyi Cen,Tianxiao Wang et al.
Panpan Peng et al.
Esophageal squamous cell carcinoma (ESCC) exhibits high prevalence in China and poor prognosis despite neoadjuvant chemotherapy (NACT), with significant chemoresistance development. Tumor-associated metabolic reprogramming and NACT-induced ...
Identification of MHC ligands through allele-guided isolation combined with machine learning for improved MHC assignment using ARDisplay-I [0.03%]
基于机器学习的结合allele引导隔离鉴定MHC配体用于改进ARDisplay-I的MHC分配
Shima Mecklenbräuker,Piotr Skoczylas,Paweł Biernat et al.
Shima Mecklenbräuker et al.
The isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for T cell-based immunotherapies. However, as many targets of high tumor specificity are only presented at low ab...