EGFR phosphorylates and associates with EFNB1 to regulate cell adhesion to fibronectin [0.03%]
EGFR磷酸化并结合EFNB1调节细胞与纤连蛋白的粘附作用
Ana I Osornio-Hernández,François J M Chartier,Tim L Schuehle et al.
Ana I Osornio-Hernández et al.
Ephrin-Bs (EFNB1-3) are ligands for members of the largest subfamily of receptor tyrosine kinases (RTKs) in humans, the EPH receptors. Interestingly, ephrin-Bs are transmembrane proteins that may also act as receptors themselves upon EPH bi...
Extracellular vesicles bearing vimentin drive epithelial-mesenchymal transition [0.03%]
携带波形蛋白的细胞外囊泡驱动上皮间质转化
Sepideh Parvanian,Leila S Coelho-Rato,Michael Santos Silva et al.
Sepideh Parvanian et al.
Epithelial-mesenchymal transition (EMT) is a key biological process in physiological and pathological conditions, spanning development, wound healing, and cancer. Vimentin, a key cytoskeletal intermediate filament (IF) protein, is an establ...
Proteomic landscape of colorectal cancer derived liver metastasis reveals three distinct phenotypes with specific signalling and enhanced survival [0.03%]
结直肠癌肝转移的蛋白质组景观揭示了具有特异性信号传导和增强存活能力的三种不同表型
Paula Nissen,Nadezhda V Popova,Antonia Gocke et al.
Paula Nissen et al.
Colorectal carcinoma is a major global disease with the second highest mortality rate among carcinomas. The liver is the most common site for metastases which portends a poor prognosis. Nonetheless, considerable heterogeneity of colorectal ...
Generation of a Deep Mouse Brain Spectral Library for Transmembrane Proteome Profiling in Mental Disease Models [0.03%]
用于精神疾病模型跨膜蛋白质组特征分析的深度小鼠脑谱库构建
Shanshan Li,Huoqing Luo,Pan Tang et al.
Shanshan Li et al.
NovoBoard: A Comprehensive Framework for Evaluating the False Discovery Rate and Accuracy of De Novo Peptide Sequencing [0.03%]
NovoBoard：评估从头肽测序的假发现率和准确性的全面框架
Ngoc Hieu Tran,Rui Qiao,Zeping Mao et al.
Ngoc Hieu Tran et al.
Proteome profiling of cerebrospinal fluid and machine learning reveal protein classifiers of two forms of Alzheimer's disease characterized by increased or not altered levels of tau [0.03%]
基于脑脊液蛋白质组学和机器学习发现两种形式的阿尔茨海默病的分类蛋白标志物
Elisabetta Scalia,Matteo Calligaris,Margot Lo Pinto et al.
Elisabetta Scalia et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that presents with heterogeneous clinical and pathological features, necessitating improved biomarkers for accurate diagnosis and patient stratification. In this study,...
Signatures of the systemic effects of a snake venom and antivenom: multiomics profiling of the kidney pathology [0.03%]
毒液和抗蛇毒血清的系统效应的肾脏病理多组学特征分析
Alison F A Chaves,Bianca C S C de Barros,Miguel Cosenza-Contreras et al.
Alison F A Chaves et al.
Animal venoms comprise many toxins that work in concert to break apart the robust homeostatic systems of prey organisms. Conversely, prey organisms actively antagonize each step of envenoming, which displays a complex kinetics involving imp...
A Roadmap for Improving Reliability and Data Sharing in Crosslinking Mass Spectrometry [0.03%]
交联质谱可靠性和数据共享改进路线图
Juri Rappsilber,James Bruce,Colin Combe et al.
Juri Rappsilber et al.
Crosslinking Mass Spectrometry (MS) can uncover protein-protein interactions and provide structural information on proteins in their native cellular environments. Despite its promise, the field remains hampered by inconsistent data formats,...
A Methanolic Urea-enhanced Protein Extraction Enabling the Largest Bacterial Phosphorylation Resource [0.03%]
一种甲醇含脲蛋白提取法建立细菌磷酸化资源库
Pei-Shan Wu,Ting-An Chen,Bo-Yu Chen et al.
Pei-Shan Wu et al.
Mass spectrometry (MS)-based phosphoproteomics analysis is a powerful approach for elucidating the regulatory roles of protein phosphorylation across all domain of life. However, bacterial phosphoproteomics still faces significant technical...
Driving Therapeutic Innovation in Neurodegenerative Disease with Hydrogen Deuterium eXchange Mass Spectrometry [0.03%]
氢氘交换质谱在神经退行性疾病药物研发中的应用与展望
Andrea Pierangelini,Benedikt M Kessler,Darragh P O&#x;Brien
Andrea Pierangelini
Human neurodegenerative conditions such as Parkinson's and Alzheimer's Disease are characterized by the formation and deposition of toxic protein species which exacerbate neuronal dysfunction, impacting the structure and function of the hea...