PhosphoDisco: A Toolkit for Co-regulated Phosphorylation Module Discovery in Phosphoproteomic Data [0.03%]
磷酸化蛋白质组数据中共调控磷酸化模块发现工具包磷 disco：磷酸蛋白质组数据中共调控磷酸化模块发现工具包
Tobias Schraink,Lili Blumenberg,Grant Hussey et al.
Tobias Schraink et al.
Kinases are key players in cancer-relevant pathways and are the targets of many successful precision cancer therapies. Phosphoproteomics is a powerful approach to study kinase activity and has been used increasingly for the characterization...
Inducible Protein Degradation as a Strategy to Identify Phosphoprotein Phosphatase 6 Substrates in RAS-Mutant Colorectal Cancer Cells [0.03%]
泛素蛋白酶体系统在KRAS突变结直肠癌细胞中鉴定PP6底物的功能研究
Natasha C Mariano,Scott F Rusin,Isha Nasa et al.
Natasha C Mariano et al.
Protein phosphorylation is an essential regulatory mechanism that controls most cellular processes, including cell cycle progression, cell division, and response to extracellular stimuli, among many others, and is deregulated in many diseas...
Deciphering Nucleic Acid Binding Proteome of Mouse Immune Organs Reveals Hub Proteins for Aging [0.03%]
解码小鼠免疫器官核酸结合蛋白并揭示衰老核心蛋白
Huiyu Wang,Yan Zhang,Zeyuan Wang et al.
Huiyu Wang et al.
Profiling the nucleic acid-binding proteins (NABPs) during aging process is critical to elucidate its roles in biological systems as well as transcriptional and translational regulation. Here, we developed a comprehensive strategy to survey...
Unified Workflow for the Rapid and In-Depth Characterization of Bacterial Proteomes [0.03%]
用于快速深入表征细菌蛋白质组的统一工作流程
Miriam Abele,Etienne Doll,Florian P Bayer et al.
Miriam Abele et al.
Bacteria are the most abundant and diverse organisms among the kingdoms of life. Due to this excessive variance, finding a unified, comprehensive, and safe workflow for quantitative bacterial proteomics is challenging. In this study, we hav...
Evolutionary Quantitative Proteomics of Reproductive Protein Divergence in Drosophila [0.03%]
果蝇生殖蛋白分化中的进化定量蛋白质组学
Martin D Garlovsky,Yasir H Ahmed-Braimah
Martin D Garlovsky
Reproductive traits often evolve rapidly between species. Understanding the causes and consequences of this rapid divergence requires characterization of female and male reproductive proteins and their effect on fertilization success. Speci...
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides [0.03%]
苯并磺酰胺小分子选择性抑制去泛素化酶USP30的结构基础
Darragh P O&#x;Brien,Hannah B L Jones,Franziska Guenther et al.
Darragh P O&#x;Brien et al.
Dampening functional levels of the mitochondrial deubiquitylating enzyme Ubiquitin-specific protease 30 (USP30) has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson's Disease. USP30 i...
Dissecting Detergent-Insoluble Proteome in Alzheimer's Disease by TMTc-Corrected Quantitative Mass Spectrometry [0.03%]
基于TMTc矫正的定量质谱分析阿兹海默病样品中吐温80不溶蛋白组分的区别
Masihuz Zaman,Yingxue Fu,Ping-Chung Chen et al.
Masihuz Zaman et al.
Protein aggregation of amyloid-β peptides and tau are pathological hallmarks of Alzheimer's disease (AD), which are often resistant to detergent extraction and thus enriched in the insoluble proteome. However, additional proteins that coac...
An Atlas of the Knee Joint Proteins and Their Role in Osteoarthritis Defined by Literature Mining [0.03%]
膝关节蛋白图谱及其在骨关节炎中的作用的文献挖掘研究
Rocío Paz-González,Lucía Lourido,Valentina Calamia et al.
Rocío Paz-González et al.
Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common locations of OA is the knee. ...
Maria Hasman,Manuel Mayr,Konstantinos Theofilatos
Maria Hasman
Biological networks have been widely used in many different diseases to identify potential biomarkers and design drug targets. In the present review, we describe the main computational techniques for reconstructing and analyzing different t...
Facioscapulohumeral Muscular Dystrophy is Associated With Altered Myoblast Proteome Dynamics [0.03%]
面部肩胛肱型肌营养不良与异化的肌细胞蛋白质组动力学相关
Yusuke Nishimura,Adam J Bittel,Connor A Stead et al.
Yusuke Nishimura et al.
Proteomic studies in facioscapulohumeral muscular dystrophy (FSHD) could offer new insight into disease mechanisms underpinned by post-transcriptional processes. We used stable isotope (deuterium oxide; D2O) labeling and peptide mass spectr...