Pan-Cancer Proteomics Analysis to Identify Tumor-Enriched and Highly Expressed Cell Surface Antigens as Potential Targets for Cancer Therapeutics [0.03%]
泛癌症蛋白质基因组分析鉴定肿瘤富集的和高表达的细胞表面抗原作为癌症治疗的潜在靶点
Jixin Wang,Wen Yu,Rachel D&#x;Anna et al.
Jixin Wang et al.
The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) provides unique opportunities for cancer target discovery using protein expression. Proteomics data from CPTAC tumor types have been primarily generated us...
Proteomics Identifies Circulating TIMP-1 as a Prognostic Biomarker for Diffuse Large B-Cell Lymphoma [0.03%]
蛋白质组学鉴定循环TIMP-1作为弥漫性大B细胞淋巴瘤的预后生物标志物
Ning Lou,Guibin Wang,Yanrong Wang et al.
Ning Lou et al.
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, although disease stratification using in-depth plasma proteomics has not been performed to date. By measuring more than 1000 proteins in the plasma of 147 DLBCL patients usin...
EGFR-T790M Mutation-Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer [0.03%]
非小细胞肺癌中表皮生长因子受体T790M衍生的互作组重编程导致吉非替尼耐药及表皮生长因子受体转位贡献机制研究
Pei-Shan Wu,Miao-Hsia Lin,Jye-Chian Hsiao et al.
Pei-Shan Wu et al.
Secondary mutation, T790M, conferring tyrosine kinase inhibitors (TKIs) resistance beyond oncogenic epidermal growth factor receptor (EGFR) mutations presents a challenging unmet need. Although TKI-resistant mechanisms are intensively inves...
A Comparative Analysis of Data Analysis Tools for Data-Independent Acquisition Mass Spectrometry [0.03%]
用于数据非依赖性获取质谱的数种数据分析工具比较分析
Fangfei Zhang,Weigang Ge,Lingling Huang et al.
Fangfei Zhang et al.
Data-independent acquisition (DIA) mass spectrometry-based proteomics generates reproducible proteome data. The complex processing of the DIA data has led to the development of multiple data analysis tools. In this study, we assessed the pe...
Glycoproteomics of a Single Protein: Revealing Tens of Thousands of Myozyme Glycoforms by Hybrid HPLC-MS Approaches [0.03%]
单蛋白糖蛋白质组学：通过混合型高效液相色谱与质谱联用技术揭示数万种Myozyme糖基化形式
Fiammetta Di Marco,Constantin Blöchl,Wolfgang Esser-Skala et al.
Fiammetta Di Marco et al.
Characterization of highly glycosylated biopharma-ceuticals by mass spectrometry is challenging because of the huge chemical space of coexistent glycoforms present. Here, we report the use of an array of HPLC-mass spectrometry-based approac...
Monitoring Both Extended and Tryptic Forms of Stable Isotope-Labeled Standard Peptides Provides an Internal Quality Control of Proteolytic Digestion in Targeted Mass Spectrometry-Based Assays [0.03%]
监控稳定同位素标记标准肽的延长形式和胰蛋白酶消化形式可为靶向质谱分析中的蛋白酶消化提供内部质量控制
Rachel A Lundeen,Jacob J Kennedy,Oscar D Murillo et al.
Rachel A Lundeen et al.
Targeted mass spectrometry (MS)-based proteomic assays, such as multiplexed multiple reaction monitoring (MRM)-MS assays, enable sensitive and specific quantification of proteotypic peptides as stoichiometric surrogates for proteins. Effort...
Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics [0.03%]
人类硫酸软骨素糖蛋白组的研究揭示了糖基硫酸化与连接位点特征之间的意外相关性
Fredrik Noborn,Jonas Nilsson,Carina Sihlbom et al.
Fredrik Noborn et al.
Chondroitin sulfate proteoglycans (CSPGs) control key events in human health and disease and are composed of chondroitin sulfate (CS) polysaccharide(s) attached to different core proteins. Detailed information on the biological effects of s...
Post-Translational Modification β-Hydroxybutyrylation Regulates Ustilaginoidea virens Virulence [0.03%]
泛素连接酶Ubi4介导的Mla蛋白泛素化修饰调控小麦对稻瘟线菌的抗病性研究
Xiaoyang Chen,Yuhang Duan,Zhiyong Ren et al.
Xiaoyang Chen et al.
Lysine β-hydroxybutyrylation (Kbhb) is an evolutionarily conserved and widespread post-translational modification that is associated with active gene transcription and cellular proliferation. However, its role in phytopathogenic fungi rema...
Impact of Asialoglycoprotein Receptor and Mannose Receptor Deficiency on Murine Plasma N-glycome Profiles [0.03%]
Asialoglycoprotein受体和甘露糖受体缺陷对小鼠血浆N-连接聚糖谱型的影响
M Svecla,J Nour,M R Bladergroen et al.
M Svecla et al.
The asialoglycoprotein receptor (ASGPR) and the mannose receptor C-type 1 (MRC1) are well known for their selective recognition and clearance of circulating glycoproteins. Terminal galactose and N-Acetylgalactosamine are recognized by ASGPR...
Identifying Patients With Rapid Progression From Hormone-Sensitive to Castration-Resistant Prostate Cancer: A Retrospective Study [0.03%]
识别前列腺癌患者从激素敏感型向去势抵抗型快速进展的回顾性研究
Chenxi Pan,Yi He,He Wang et al.
Chenxi Pan et al.
Prostate cancer (PCa) is the second most prevalent malignancy and the fifth cause of cancer-related deaths in men. A crucial challenge is identifying the population at risk of rapid progression from hormone-sensitive prostate cancer (HSPC) ...