A Multipathway Phosphopeptide Standard for Rapid Phosphoproteomics Assay Development [0.03%]
用于快速磷酸蛋白质组学测定开发的多通路磷肽标准品
Brian C Searle,Allis Chien,Antonius Koller et al.
Brian C Searle et al.
Recent advances in methodology have made phosphopeptide analysis a tractable problem for many proteomics researchers. There are now a wide variety of robust and accessible enrichment strategies to generate phosphoproteomes while free or ine...
CREB-Regulated Transcriptional Coactivator 2 Proteome Landscape is Modulated by SREBF1 [0.03%]
SREBF1调控的CREB调节转录辅激活子2蛋白质谱系特征
Jae Min Lim,Muhammad Ayaz Anwar,Hye-Sook Han et al.
Jae Min Lim et al.
cAMP response element-binding protein (CREB) regulated transcriptional coactivator 2 (CRTC2) is a critical transcription factor that maintains glucose homeostasis by activating CREB. Energy homeostasis is maintained through multiple pathway...
An Introduction to Analytical Challenges, Approaches, and Applications in Mass Spectrometry-Based Secretomics [0.03%]
基于质谱的分泌组学分析挑战、方法及应用介绍
Sascha Knecht,H Christian Eberl,Norbert Kreisz et al.
Sascha Knecht et al.
The active release of proteins into the extracellular space and the proteolytic cleavage of cell surface proteins are key processes that coordinate and fine-tune a multitude of physiological functions. The entirety of proteins that fulfill ...
Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc [0.03%]
人类乳糖寡糖含有免疫调节葡萄糖酸和N-乙酰乳糖尿脎
Chunsheng Jin,Jon Lundstrøm,Emma Korhonen et al.
Chunsheng Jin et al.
Breast milk is abundant with functionalized milk oligosaccharides (MOs) to nourish and protect the neonate. Yet we lack a comprehensive understanding of the repertoire and evolution of MOs across Mammalia. We report ∼400 MO-species associa...
High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells [0.03%]
高通量筛选和蛋白质组分析靶向髓源性抑制细胞的化合物
Johannes Krumm,Elissaveta Petrova,Severin Lechner et al.
Johannes Krumm et al.
Myeloid-derived suppressor cells (MDSC) are a heterogeneous cell population of incompletely differentiated immune cells. They are known to suppress T cell activity and are implicated in multiple chronic diseases, which make them an attracti...
What Can Ribo-Seq, Immunopeptidomics, and Proteomics Tell Us About the Noncanonical Proteome? [0.03%]
核糖体 profiling、免疫肽组学和蛋白质组学揭示非经典蛋白编码的情况如何？
John R Prensner,Jennifer G Abelin,Leron W Kok et al.
John R Prensner et al.
Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of the human genome and proteome by illuminating thousands of noncanonical sites of ribosome translation outside the currently annotated coding sequences (CDSs). ...
Obtaining Functional Proteomics Insights From Thermal Proteome Profiling Through Optimized Melt Shift Calculation and Statistical Analysis With InflectSSP [0.03%]
利用优化的熔解位移计算和InflectSSP统计分析从热蛋白组学谱型中获得功能蛋白质组学见解
Neil A McCracken,Hao Liu,Avery M Runnebohm et al.
Neil A McCracken et al.
Thermal proteome profiling (TPP) is an invaluable tool for functional proteomics studies that has been shown to discover changes associated with protein-ligand, protein-protein, and protein-RNA interaction dynamics along with changes in pro...
Methods to Discover and Validate Biofluid-Based Biomarkers in Neurodegenerative Dementias [0.03%]
神经退行性痴呆的体液生物标志物发现与验证方法学研究进展
Charlotte E Teunissen,Leighann Kimble,Sherif Bayoumy et al.
Charlotte E Teunissen et al.
Neurodegenerative dementias are progressive diseases that cause neuronal network breakdown in different brain regions often because of accumulation of misfolded proteins in the brain extracellular matrix, such as amyloids or inside neurons ...
Angus C Grey,Qingsong Lin,Teck Yew Low et al.
Angus C Grey et al.
As the first in-person Asia Oceania Human Proteomics Organization (AOHUPO) congress since 2018, the 11th AOHUPO congress was an opportune time for the research community to reconnect and to renew friendships after the long period of restric...
The Hyperproliferation Mechanism of Cholesteatoma Based on Proteomics: SNCA Promotes Autophagy-Mediated Cell Proliferation Through the PI3K/AKT/CyclinD1 Signaling Pathway [0.03%]
基质蛋白质组学鉴定SNCA通过PI3K/AKT/CCND1信号通路促进自噬介导的角化细胞增殖以驱动胆脂瘤上皮异常浸润和增生
Miao Gao,Heng Xiao,Yonglan Liang et al.
Miao Gao et al.
Cholesteatoma is a chronic inflammatory ear disease with abnormal keratinized epithelium proliferation and tissue damage. However, the mechanism of keratinized epithelium hyperproliferation in cholesteatoma remains unknown. Hence, our study...