Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses [0.03%]
通过对脉络膜黑色素瘤的磷酸化蛋白质组学和生物信息学分析发现由癌基因Gq/11驱动的蛋白激酶信号网络
Michael D Onken,Petra Erdmann-Gilmore,Qiang Zhang et al.
Michael D Onken et al.
Metastatic uveal melanoma (UM) patients typically survive only 2 to 3 years because effective therapy does not yet exist. Here, to facilitate the discovery of therapeutic targets in UM, we have identified protein kinase signaling mechanisms...
William S Phipps,Mark R Kilgore,Jacob J Kennedy et al.
William S Phipps et al.
The evaluation of biopsied solid organ tissue has long relied on visual examination using a microscope. Immunohistochemistry is critical in this process, labeling and detecting cell lineage markers and therapeutic targets. However, while th...
Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC [0.03%]
头颈癌中NRF2信号传导及预测生物标志物的靶向蛋白质组定量研究
Nathan T Wamsley,Emily M Wilkerson,Li Guan et al.
Nathan T Wamsley et al.
The NFE2L2 (NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion, and chemoradiation resistance. Patient stratification by NRF2 activity may guide...
Integrated Immunopeptidomics and Proteomics Study of SARS-CoV-2-Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation [0.03%]
整合免疫肽组学和蛋白质组学研究揭示了SARS-CoV-2感染的Calu-3细胞中等位基因特异性HLA丰度及抗原呈递的动态变化
Rui Chen,Kelly M Fulton,Anh Tran et al.
Rui Chen et al.
We present an integrated immunopeptidomics and proteomics study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to comprehensively decipher the changes in host cells in response to viral infection. Immunopeptidomic...
Quantitative Time-Course Analysis of Osmotic and Salt Stress in Arabidopsis thaliana Using Short Gradient Multi-CV FAIMSpro BoxCar DIA [0.03%]
基于短梯度多CV FAIMSpro BoxCar DIA的拟南芥渗调和盐胁迫定量时间进程分析
M C Rodriguez Gallo,Q Li,M Talasila et al.
M C Rodriguez Gallo et al.
A major limitation when undertaking quantitative proteomic time-course experimentation is the tradeoff between depth-of-analysis and speed-of-analysis. In high complexity and high dynamic range sample types, such as plant extracts, balance ...
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4-Associated Factors, Cellular Functions, and Protein Substrates [0.03%]
脉冲-SILAC与互作组学揭示了不同的DDB1-CUL4相互作用因子、细胞功能及蛋白质底物
Jennifer Raisch,Marie-Line Dubois,Marika Groleau et al.
Jennifer Raisch et al.
Cullin-RING finger ligases represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ∼20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a ...
A Standardized and Reproducible Workflow for Membrane Glass Slides in Routine Histology and Spatial Proteomics [0.03%]
膜玻璃载片的常规组织学和空间蛋白质组学的标准可重现工作流程
Thierry M Nordmann,Lisa Schweizer,Andreas Metousis et al.
Thierry M Nordmann et al.
Defining the molecular phenotype of single cells in situ is key for understanding tissue architecture in health and disease. Advanced imaging platforms have recently been joined by spatial omics technologies, promising unparalleled insights...
Uterine Fluid Extracellular Vesicles Proteome Is Altered During the Estrous Cycle [0.03%]
子宫液细胞外囊泡蛋白质组在发情周期中发生变化
Johanna Piibor,Andres Waldmann,Keerthie Dissanayake et al.
Johanna Piibor et al.
Uterine environment is tightly and finely regulated via various signaling pathways mediated through endocrine, exocrine, autocrine, juxtacrine, and paracrine mechanisms. In utero signaling processes are paramount for normal and abnormal phy...
Lactate and Lactylation: Clinical Applications of Routine Carbon Source and Novel Modification in Human Diseases [0.03%]
乳酸和乳酸化：人类疾病的常规碳源和新颖修饰的临床应用
Zhimin Wang,Dan Hao,Shuiying Zhao et al.
Zhimin Wang et al.
Cell metabolism generates numerous intermediate metabolites that could serve as feedback and feed-forward regulation substances for posttranslational modification. Lactate, a metabolic product of glycolysis, has recently been conceptualized...
PaxDb 5.0: Curated Protein Quantification Data Suggests Adaptive Proteome Changes in Yeasts [0.03%]
PaxDb 5.0：经过筛选的蛋白质定量数据表明酵母中的适应性蛋白质变化
Qingyao Huang,Damian Szklarczyk,Mingcong Wang et al.
Qingyao Huang et al.
The "Protein Abundances Across Organisms" database (PaxDb) is an integrative metaresource dedicated to protein abundance levels, in tissue-specific or whole-organism proteomes. PaxDb focuses on computing best-estimate abundances for protein...