Proteomic and Phosphoproteomic Reprogramming in Epithelial Ovarian Cancer Metastasis [0.03%]
上皮性卵巢癌转移的蛋白质组和磷酸化蛋白质组的重新编程
Mallory I Frederick,Owen F J Hovey,Jenica H Kakadia et al.
Mallory I Frederick et al.
Epithelial ovarian cancer (EOC) is a high-risk cancer presenting with heterogeneous tumors. The high incidence of EOC metastasis from primary tumors to nearby tissues and organs is a major driver of EOC lethality. We used cellular models of...
Experience-Induced Remodeling of the Hippocampal Post-synaptic Proteome and Phosphoproteome [0.03%]
经历诱导的海马突触后蛋白质和磷酸化蛋白质组的重塑
Seok Heo,Taewook Kang,Alexei M Bygrave et al.
Seok Heo et al.
The postsynaptic density (PSD) of excitatory synapses contains a highly organized protein network with thousands of proteins and is a key node in the regulation of synaptic plasticity. To gain new mechanistic insight into experience-induced...
Baldur: Bayesian Hierarchical Modeling for Label-Free Proteomics with Gamma Regressing Mean-Variance Trends [0.03%]
基于伽玛回归均值-方差趋势的贝叶斯层次模型在无标记蛋白质组学中的应用：巴德尔
Philip Berg,George Popescu
Philip Berg
Label-free proteomics is a fast-growing methodology to infer abundances in mass spectrometry proteomics. Extensive research has focused on spectral quantification and peptide identification. However, research toward modeling and understandi...
Proteomics and β-hydroxybutyrylation Modification Characterization in the Hearts of Naturally Senescent Mice [0.03%]
自然衰老小鼠心肌蛋白质组及β-羟基丁缩醛化修饰变化特征分析
Xuechun Yang,Xuehui Li,Na Yu et al.
Xuechun Yang et al.
Aging is widely accepted as an independent risk factor for cardiovascular disease (CVD), which contributes to increasing morbidity and mortality in the elderly population. Lysine β-hydroxybutyrylation (Kbhb) is a novel post-translational m...
Higher-Order Structural Organization of the Mitochondrial Proteome Charted by In Situ Cross-Linking Mass Spectrometry [0.03%]
基于原位交联质谱的线粒体蛋白质组高阶结构图谱研究
Johannes F Hevler,Albert J R Heck
Johannes F Hevler
Mitochondria are densely packed with proteins, of which most are involved physically or more transiently in protein-protein interactions (PPIs). Mitochondria host among others all enzymes of the Krebs cycle and the oxidative phosphorylation...
The Role of Serine/Threonine-Specific Protein Kinases in Cyanobacteria - SpkB Is Involved in Acclimation to Fluctuating Conditions in Synechocystis sp. PCC 6803 [0.03%]
参与颤蓝细菌适应环境波动的丝氨酸/苏氨酸特异性蛋白激酶-SpycblpKb在集胞藻中的作用
Thomas Barske,Philipp Spät,Hendrik Schubert et al.
Thomas Barske et al.
Protein phosphorylation via serine/threonine protein kinases (Spk) is a widespread mechanism to adjust cellular processes toward changing environmental conditions. To study their role(s) in cyanobacteria, we investigated a collection of 11 ...
Early Proteomic Characteristics and Changes in the Optic Nerve Head, Optic Nerve, and Retina in a Rat Model of Ocular Hypertension [0.03%]
ocular hypertension大鼠模型视神经头、视神经和视网膜的早期蛋白组特征及变化
Danting Lin,Shen Wu,Ying Cheng et al.
Danting Lin et al.
The pathogenesis of glaucoma is still unknown. There are few studies on the dynamic change of tissue-specific and time-specific molecular pathophysiology caused by ocular hypertension (OHT). This study aimed to identify the early proteomic ...
Impact of Bmal1 Rescue and Time-Restricted Feeding on Liver and Muscle Proteomes During the Active Phase in Mice [0.03%]
Bmal1恢复和活动期小鼠肝脏和肌肉蛋白组的时间限制性进食影响研究
Jacob G Smith,Jeffrey Molendijk,Ronnie Blazev et al.
Jacob G Smith et al.
Molecular clocks and daily feeding cycles support metabolism in peripheral tissues. Although the roles of local clocks and feeding are well defined at the transcriptional level, their impact on governing protein abundance in peripheral tiss...
Al Burlingame
Al Burlingame
FMRP Long-Range Transport and Degradation Are Mediated by Dynlrb1 in Sensory Neurons [0.03%]
Dynlrb1介导感觉神经元中的FMRP长程运输和降解
Sara Emad El-Agamy,Laurent Guillaud,Keiko Kono et al.
Sara Emad El-Agamy et al.
The fragile X messenger ribonucleoprotein 1 (FMRP) is a multifunctional RNA-binding protein implicated in human neurodevelopmental and neurodegenerative disorders. FMRP mediates the localization and activity-dependent translation of its ass...