Multitissue Circadian Proteome Atlas of WT and Per1-/-/Per2-/- Mice [0.03%]
野生型和Per1-/-/Per2-/- 基因敲除小鼠的多组织昼夜周期蛋白质图谱
Liujia Qian,Yue Gu,Qiaocheng Zhai et al.
Liujia Qian et al.
The molecular basis of circadian rhythm, driven by core clock genes such as Per1/2, has been investigated on the transcriptome level, but not comprehensively on the proteome level. Here we quantified over 11,000 proteins expressed in eight ...
The Salmonella Typhimurium Effector SpvB Subverts Host Membrane Trafficking by Targeting Clathrin and AP-1 [0.03%]
沙门氏菌效应蛋白SpvB通过靶向适应体和AP-1亚细胞重塑宿主膜 trafficking
Yi Yuan,Xinghao Wang,Jie Jin et al.
Yi Yuan et al.
Salmonella enterica, the etiological agent of gastrointestinal and systemic diseases, translocates a plethora of virulence factors through its type III secretion systems to host cells during infection. Among them, SpvB has been reported to ...
Proteomics, Transcriptomics, and Phosphoproteomics Reveal the Mechanism of Talaroconvolutin-A Suppressing Bladder Cancer via Blocking Cell Cycle and Triggering Ferroptosis [0.03%]
蛋白质组、转录组和磷酸化蛋白质组揭示塔拉卷丝素A通过阻断细胞周期和诱导铁死亡抑制膀胱癌的机制
Yong Xia,Longquan Xiang,Ming Yao et al.
Yong Xia et al.
Talaroconvolutin-A (TalaA) is a compound from the endophytic fungus T. convolutispora of the Chinese herbal medicine Panax notoginseng. Whether TalaA exerts anticancer activity in bladder cancer remains unknown. Using CCK8 assay, EdU staini...
Biochemical Deconstruction and Reconstruction of Nuclear Matrix Reveals the Layers of Nuclear Organization [0.03%]
核基质的生化解构与重建揭示了细胞核的多层次组织结构
Ashish Bihani,Akshay K Avvaru,Rakesh K Mishra
Ashish Bihani
Nuclear matrix (NuMat) is the fraction of the eukaryotic nucleus insoluble to detergents and high-salt extractions that manifests as a pan-nuclear fiber-granule network. NuMat consists of ribonucleoprotein complexes, members of crucial nucl...
Integrative Proteomic Analysis Reveals the Cytoskeleton Regulation and Mitophagy Difference Between Ischemic Cardiomyopathy and Dilated Cardiomyopathy [0.03%]
整合蛋白质组分析揭示缺血性心肌病和扩张型心肌病的细胞骨架调节和线粒体自噬差异
Muyin Liu,Linhui Zhai,Zhaohua Yang et al.
Muyin Liu et al.
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome...
High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology [0.03%]
采用“建立和检索”方法对线粒体进行高分辨率结构蛋白质组学研究
Zhemin Zhang,Marios L Tringides,Christopher E Morgan et al.
Zhemin Zhang et al.
The application of integrated systems biology to the field of structural biology is a promising new direction, although it is still in the infant stages of development. Here we report the use of single particle cryo-EM to identify multiple ...
An Automated Nanowell-Array Workflow for Quantitative Multiplexed Single-Cell Proteomics Sample Preparation at High Sensitivity [0.03%]
一种用于高灵敏度定量多重单细胞蛋白质组样本制备的自动化纳米井阵列工作流程
Claudia Ctortecka,David Hartlmayr,Anjali Seth et al.
Claudia Ctortecka et al.
Multiplexed and label-free mass spectrometry-based approaches with single-cell resolution have attributed surprising heterogeneity to presumed homogenous cell populations. Even though specialized experimental designs and instrumentation hav...
Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome [0.03%]
Ixodes ricinus幼虫中期肠道蛋白组的动态分析
Tereza Kozelková,Filip Dyčka,Stephen Lu et al.
Tereza Kozelková et al.
Ticks are ectoparasites that feed on blood and have an impressive ability to consume and process enormous amounts of host blood, allowing extremely long periods of starvation between blood meals. The central role in the parasitic lifestyle ...
Global Analysis of Post-Translational Side-Chain Arginylation Using Pan-Arginylation Antibodies [0.03%]
基于泛_arginylation抗体的蛋白质侧链修饰的全局分析研究获奖奖项：美国化学学会蛋白质组学分会2017年度青年科学家奖作者：侴越(第一作者)，刘思敏，陈鹏通讯作者：陈鹏教授期刊：Angew. Chem. Int. Ed. 影响因子: 12.102
Brittany MacTaggart,Marie Shimogawa,Marshall Lougee et al.
Brittany MacTaggart et al.
Arginylation is a post-translational modification mediated by the arginyltransferase 1 (ATE1), which transfers the amino acid arginine to a protein or peptide substrate from a tRNA molecule. Initially, arginylation was thought to occur only...
Chemical Proteomic Approach for In-Depth Glycosylation Profiling of Plasma Carcinoembryonic Antigen in Cancer Patients [0.03%]
用于癌症患者血浆癌胚抗原深入 glycoprofiling 的化学蛋白质组学方法
Jin Chen,Lijun Yang,Chang Li et al.
Jin Chen et al.
Carcinoembryonic antigen (CEA) of human plasma is a biomarker of many cancer diseases, and its N-glycosylation accounts for 60% of molecular mass. It is highly desirable to characterize its glycoforms for providing additional dimension of f...