Identification of Proteome-Based Immune Subtypes of Early Hepatocellular Carcinoma and Analysis of Potential Metabolic Drivers [0.03%]
基于蛋白质组的免疫分型在早期肝细胞癌中的识别及其潜在代谢驱动因素分析
Lihong Diao,Mengqi He,Binsheng Xu et al.
Lihong Diao et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, ranking fourth in frequency. The relationship between metabolic reprogramming and immune infiltration has been identified as having a crucial impact on...
Protein Phosphorylation Orchestrates Acclimations of Arabidopsis Plants to Environmental pH [0.03%]
蛋白质磷酸化调控拟南芥植物对环境pH的适应反应
Dharmesh Jain,Wolfgang Schmidt
Dharmesh Jain
Environment pH (pHe) is a key parameter dictating a surfeit of conditions critical to plant survival and fitness. To elucidate the mechanisms that recalibrate cytoplasmic and apoplastic pH homeostasis, we conducted a comprehensive proteomic...
Integrative Proteogenomics for Differential Expression and Splicing Variation in a DM1 Mouse Model [0.03%]
用于DM1小鼠模型中差异表达和剪接变异的蛋白质组学研究
Elizaveta M Solovyeva,Stephan Utzinger,Alexandra Vissières et al.
Elizaveta M Solovyeva et al.
Dysregulated mRNA splicing is involved in the pathogenesis of many diseases including cancer, neurodegenerative diseases, and muscular dystrophies such as myotonic dystrophy type 1 (DM1). Comprehensive assessment of dysregulated splicing on...
Sara R Savage,Yaoyun Zhang,Eric J Jaehnig et al.
Sara R Savage et al.
Global phosphoproteomics experiments quantify tens of thousands of phosphorylation sites. However, data interpretation is hampered by our limited knowledge on functions, biological contexts, or precipitating enzymes of the phosphosites. Thi...
Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica [0.03%]
肝片吸虫感染阶段体液提取物和分泌组的糖蛋白糖型复杂度及异质性
Carolina De Marco Verissimo,Krystyna Cwiklinski,Jonas Nilsson et al.
Carolina De Marco Verissimo et al.
Fasciola hepatica is a global helminth parasite of humans and their livestock. The invasive stage of the parasite, the newly excysted juvenile (NEJs), relies on glycosylated excreted-secreted (ES) products and surface/somatic molecules to i...
Influence of the Heme Nitric Oxide/Oxygen Binding Protein (H-NOX) on Cell Cycle Regulation in Caulobacter crescentus [0.03%]
血红素(NO/O2结合蛋白(H-NOX)对细胞周期调节的影响 Crescentus中的细胞周期调节
Cameron Lee-Lopez,Md Shariful Islam,Ady B Meléndez et al.
Cameron Lee-Lopez et al.
The ability of an organism to respond to environmental changes is paramount to survival across a range of conditions. The bacterial heme nitric oxide/oxygen binding proteins (H-NOX) are a family of biofilm-regulating gas sensors that enable...
Identification of State-Specific Proteomic and Transcriptomic Signatures of Microglia-Derived Extracellular Vesicles [0.03%]
识别微胶质细胞源性外泌体的州特异性蛋白质组和转录组图谱
Juliet V Santiago,Aditya Natu,Christina C Ramelow et al.
Juliet V Santiago et al.
Microglia are resident immune cells of the brain that play important roles in mediating inflammatory responses in several neurological diseases via direct and indirect mechanisms. One indirect mechanism may involve extracellular vesicle (EV...
Application of Liquid-Liquid Extraction for N-terminal Myristoylation Proteomics [0.03%]
液-液萃取技术在蛋白质N端肌棕榈酰化组学中的应用研究
Kazuya Tsumagari,Yosuke Isobe,Yasushi Ishihama et al.
Kazuya Tsumagari et al.
Proteins can be modified by lipids in various ways, for example, by myristoylation, palmitoylation, farnesylation, and geranylgeranylation-these processes are collectively referred to as lipidation. Current chemical proteomics using alkyne ...
Sandra Villar-Conde,Veronica Astillero-Lopez,Melania Gonzalez-Rodriguez et al.
Sandra Villar-Conde et al.
α-Synuclein, a protein mostly present in presynaptic terminals, accumulates neuropathologically in Parkinson's disease in a 6-stage sequence and propagates in the nervous system in a prion-like manner through neurons and glia. In stage 3, ...
HIV-1 Nef Changes the Proteome of T Cells Extracellular Vesicles Depleting IFITMs and Other Antiviral Factors [0.03%]
HIV-1 Nef通过减少IFITM及其他抗病毒因子改变T细胞外泌体蛋白组成
Mara E da Silva-Januário,Cristina S da Costa,Lucas A Tavares et al.
Mara E da Silva-Januário et al.
Extracellular vesicles (EVs) are biomolecule carriers for intercellular communication in health and disease. Nef is a HIV virulence factor that is released from cells within EVs and is present in plasma EVs of HIV-1 infected individuals. We...