LAFEM: A Scoring Model to Evaluate Functional Landscape of Lysine Acetylome [0.03%]
LAFEM：一种评估赖氨酸乙酰化功能景观的评分模型
Jun-Ze Liang,De-Hua Li,Yong-Chun Xiao et al.
Jun-Ze Liang et al.
Protein lysine acetylation is a critical post-translational modification involved in a wide range of biological processes. To date, about 20,000 acetylation sites of Homo sapiens were identified through mass spectrometry-based proteomic tec...
Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site [0.03%]
对纤溶酶原激活的蛋白质亚型分析发现了其新的丰富磷酸化位点和主要的N端切割位点
Dario A T Cramer,Victor Yin,Tomislav Caval et al.
Dario A T Cramer et al.
Plasminogen (Plg), the zymogen of plasmin (Plm), is a glycoprotein involved in fibrinolysis and a wide variety of other physiological processes. Plg dysregulation has been implicated in a range of diseases. Classically, human Plg is categor...
Dissecting Ubiquitylation and DNA Damage Response Pathways in the Yeast Saccharomyces cerevisiae Using a Proteome-Wide Approach [0.03%]
利用蛋白质组学方法研究模式酵母Saccharomyces cerevisiae中的泛素化和DNA损伤修复途径
Ewa Blaszczak,Emeline Pasquier,Gaëlle Le Dez et al.
Ewa Blaszczak et al.
In response to genotoxic stress, cells evolved with a complex signaling network referred to as the DNA damage response (DDR). It is now well established that the DDR depends upon various posttranslational modifications; among them, ubiquity...
iProPhos: A Web-Based Interactive Platform for Integrated Proteome and Phosphoproteome Analysis [0.03%]
iProPhos：一个基于网络的整合蛋白质组和磷酸化蛋白质组分析互动平台
Jing Zou,Ziran Qin,Ran Li et al.
Jing Zou et al.
Large-scale omics studies have generated a wealth of mass spectrometry-based proteomics data, which provide additional insights into disease biology spanning genomic boundaries. However, there is a notable lack of web-based analysis and vis...
A Causal Model of Ion Interference Enables Assessment and Correction of Ratio Compression in Multiplex Proteomics [0.03%]
因果模型离子干扰使多路蛋白质组学中的比例压缩评估和校正成为可能
Moritz Madern,Wolfgang Reiter,Florian Stanek et al.
Moritz Madern et al.
Multiplex proteomics using isobaric labeling tags has emerged as a powerful tool for the simultaneous relative quantification of peptides and proteins across multiple experimental conditions. However, the quantitative accuracy of the approa...
Secretome Analysis: Reading Cellular Sign Language to Understand Intercellular Communication [0.03%]
分泌组分析：解读细胞信号语言以了解细胞间通信
Wei Wu,Jeroen Krijgsveld
Wei Wu
A significant portion of mammalian proteomes is secreted to the extracellular space to fulfill crucial roles in cell-to-cell communication. To best recapitulate the intricate and multi-faceted crosstalk between cells in a live organism, the...
Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron Efflux [0.03%]
定量蛋白质组学鉴定出组织浸润的T细胞来自结直肠癌患者发现LCN2通过铁流出诱导T细胞凋亡并促进肿瘤细胞增殖
Rui Che,Qingsong Wang,Minzhe Li et al.
Rui Che et al.
T cells play the most pivotal roles in antitumor immunity; the T-cell proteome and the differentially expressed proteins in the tumor immune microenvironment have rarely been identified directly from the clinical samples, especially for tum...
Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients [0.03%]
深入黑暗血清蛋白质组：重症COVID-19患者IgG1和IgA1的独特个性化特征
Albert Bondt,Max Hoek,Kelly Dingess et al.
Albert Bondt et al.
Serum proteomics has matured and is now able to monitor hundreds of proteins quantitatively in large cohorts of patients. However, the fine characteristics of some of the most dominant proteins in serum, the immunoglobulins, are in these st...
IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma [0.03%]
基于IMBAS-MS的血浆HLA肽图谱鉴定及器官特异性肽模式发现
Maria Wahle,Marvin Thielert,Maximilian Zwiebel et al.
Maria Wahle et al.
Distinction of non-self from self is the major task of the immune system. Immunopeptidomics studies the peptide repertoire presented by the human leukocyte antigen (HLA) protein, usually on tissues. However, HLA peptides are also bound to p...
T Mamie Lih,Liwei Cao,Parham Minoo et al.
T Mamie Lih et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, partly because it is frequently identified at an advanced stage, when surgery is no longer feasible. Therefore, early detection using minimally invasive methods...