Deep Learning Prediction Boosts Phosphoproteomics-Based Discoveries Through Improved Phosphopeptide Identification [0.03%]
深度学习预测通过改进磷酸肽识别提高基于磷酸蛋白质组学的发现
Xinpei Yi,Bo Wen,Shuyi Ji et al.
Xinpei Yi et al.
Shotgun phosphoproteomics enables high-throughput analysis of phosphopeptides in biological samples. One of the primary challenges associated with this technology is the relatively low rate of phosphopeptide identification during data analy...
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism [0.03%]
互作分析确定了BZW2在促进内质网-线粒体接触和线粒体代谢中的作用
George Maio,Mike Smith,Ruchika Bhawal et al.
George Maio et al.
Understanding the molecular functions of less-studied proteins is an important task of life science research. Despite reports of basic leucine zipper and W2 domain-containing protein 2 (BZW2) promoting cancer progression first emerging in 2...
Multiplexed Antibody Glycosylation Profiling Using Dual Enzyme Digestion and Liquid Chromatography-Triple Quadrupole Mass Spectrometry Method [0.03%]
使用双酶消化和液相色谱-三重四极杆质谱法对抗体糖基化进行多路复用分析
Yu-Hsuan Cheng,Chih-Hsin Lee,San-Yuan Wang et al.
Yu-Hsuan Cheng et al.
Antibody glycosylation plays a crucial role in the humoral immune response by regulating effector functions and influencing the binding affinity to immune cell receptors. Previous studies have focused mainly on the immunoglobulin G (IgG) is...
msqrob2PTM: Differential Abundance and Differential Usage Analysis of MS-Based Proteomics Data at the Posttranslational Modification and Peptidoform Level [0.03%]
msqrob2PTM：基于MS的蛋白质组学数据在翻译后修饰和肽形水平上的差异丰度和差异使用分析
Nina Demeulemeester,Marie Gébelin,Lucas Caldi Gomes et al.
Nina Demeulemeester et al.
In the era of open-modification search engines, more posttranslational modifications than ever can be detected by LC-MS/MS-based proteomics. This development can switch proteomics research into a higher gear, as PTMs are key in many cellula...
Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging [0.03%]
心脏细胞外基质蛋白质组在时间性和病理老化过程中的重构
Deolinda Santinha,Andreia Vilaça,Luís Estronca et al.
Deolinda Santinha et al.
Impaired extracellular matrix (ECM) remodeling is a hallmark of many chronic inflammatory disorders that can lead to cellular dysfunction, aging, and disease progression. The ECM of the aged heart and its effects on cardiac cells during chr...
Phosphorylation Dynamics in a flg22-Induced, G Protein-Dependent Network Reveals the AtRGS1 Phosphatase [0.03%]
flg22诱导的、G蛋白依赖性网络中的磷酸化动态变化揭示了AtRGS1磷酸酶的存在
Justin M Watkins,Christian Montes,Natalie M Clark et al.
Justin M Watkins et al.
The microbe-associated molecular pattern flg22 is recognized in a flagellin-sensitive 2-dependent manner in root tip cells. Here, we show a rapid and massive change in protein abundance and phosphorylation state of the Arabidopsis root cell...
Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells [0.03%]
蛋白质组分析揭示了听觉内毛细胞谷氨酸能细胞器的组成成分
Andreia P Cepeda,Momchil Ninov,Jakob Neef et al.
Andreia P Cepeda et al.
In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory information to the brain. The presynaptic machinery responsible for neurotransmitter release in IHC synapses i...
Proteomic Analysis Revealed the Potential Role of MAGE-D2 in the Therapeutic Targeting of Triple-Negative Breast Cancer [0.03%]
蛋白质组学分析揭示了MAGE-D2在治疗三阴性乳腺癌靶标中的潜在作用
Xiaoyu Shi,Chunyan Liu,Weimin Zheng et al.
Xiaoyu Shi et al.
Among all the molecular subtypes of breast cancer, triple-negative breast cancer (TNBC) is the most aggressive one. Currently, the clinical prognosis of TNBC is poor because there is still no effective therapeutic target. Here, we carried o...
Exploring the Spatial Landscape of the Estrogen Receptor Proximal Proteome With Antibody-Based Proximity Labeling [0.03%]
基于抗体的邻近标记技术探索雌激素受体附近蛋白质的空间景观
Camilla Rega,Zuzanna Kozik,Lu Yu et al.
Camilla Rega et al.
Estrogen receptor α (ERα) drives the transcription of genes involved in breast cancer (BC) progression, relying on coregulatory protein recruitment for its transcriptional and biological activities. Mutation of ERα as well as aberrant re...
Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters [0.03%]
互作组分析发现ALMS1-CEP70复合体与中心粒簇的新联系
Franziska Woerz,Felix Hoffmann,Shibu Antony et al.
Franziska Woerz et al.
Alström syndrome (ALMS) is a very rare autosomal-recessive disorder, causing a broad range of clinical defects most notably retinal degeneration, type 2 diabetes, and truncal obesity. The ALMS1 gene encodes a complex and huge ∼0.5 MDa pro...