Alzheimer's Disease Biomarker Analysis Using Targeted Mass Spectrometry [0.03%]
使用靶向质谱法分析阿尔茨海默病的生物标志物
Johan Gobom,Ann Brinkmalm,Gunnar Brinkmalm et al.
Johan Gobom et al.
Alzheimer's disease (AD) is characterized by several neuropathological changes, mainly extracellular amyloid aggregates (plaques), intraneuronal inclusions of phosphorylated tau (tangles), as well as neuronal and synaptic degeneration, acco...
A Massive Proteogenomic Screen Identifies Thousands of Novel Peptides From the Human "Dark" Proteome [0.03%]
大规模蛋白质基因组筛选发现人类“暗”蛋白质组中数以千计的新肽段
Xiaolong Cao,Siqi Sun,Jinchuan Xing
Xiaolong Cao
Although the human gene annotation has been continuously improved over the past 2 decades, numerous studies demonstrated the existence of a "dark proteome", consisting of proteins that were critical for biological processes but not included...
Analysis of the Healthy Platelet Proteome Identifies a New Form of Domain-Specific O-Fucosylation [0.03%]
健康血小板蛋白质组的分析鉴定了一种新的O-岩藻糖基化域特异形式
Callum B Houlahan,Yvonne Kong,Bede Johnston et al.
Callum B Houlahan et al.
Platelet activation induces the secretion of proteins that promote platelet aggregation and inflammation. However, detailed analysis of the released platelet proteome is hampered by platelets' tendency to preactivate during their isolation ...
The Differential Translation Capabilities of the Human DHFR2 Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance [0.03%]
人的DHFR2基因不同的翻译能力表明了一种低量的、发育和组织特异性的内源性蛋白
Niamh Bookey,Paola Drago,Kit-Yi Leung et al.
Niamh Bookey et al.
A functional role has been ascribed to the human dihydrofolate reductase 2 (DHFR2) gene based on the enzymatic activity of recombinant versions of the predicted translated protein. However, the in vivo function is still unclear. The high am...
Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics [0.03%]
急性髓细胞白血病细胞的蛋白质组稳定化：对癌症蛋白质组学的影响
Robert W Sprung,Qiang Zhang,Michael H Kramer et al.
Robert W Sprung et al.
Previous work has shown that inhibition of abundant myeloid azurophil granule-associated serine proteases (ELANE [neutrophil elastase], PRTN3 [protease 3], and CTSG [Cathepsin G]) is required to stabilize some proteins in myeloid cells. We ...
Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence [0.03%]
核磷酸蛋白质组揭示脯氨酰异构酶PIN1为原癌基因诱导的衰老的调节者
Rodrigo Mohallem,Uma K Aryal
Rodrigo Mohallem
Mammalian cells possess intrinsic mechanisms to prevent tumorigenesis upon deleterious mutations, including oncogene-induced senescence (OIS). The molecular mechanisms underlying OIS are, however, complex and remain to be fully characterize...
Ion Mobility-Based Enrichment-Free N-Terminomics Analysis Reveals Novel Legumain Substrates in Murine Spleen [0.03%]
基于离子迁移的无需富集的N-末端组学分析揭示了小鼠脾中新的豆氨酸蛋白酶底物
Alexander R Ziegler,Antoine Dufour,Nichollas E Scott et al.
Alexander R Ziegler et al.
Aberrant levels of the asparaginyl endopeptidase legumain have been linked to inflammation, neurodegeneration, and cancer, yet our understanding of this protease is incomplete. Systematic attempts to identify legumain substrates have been p...
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis [0.03%]
全质量范围的ΦSDM Orbitrap 质谱仪用于DIA蛋白质组学分析
Sophia Steigerwald,Ankit Sinha,Kyle L Fort et al.
Sophia Steigerwald et al.
Optimizing data-independent acquisition methods for proteomics applications often requires balancing spectral resolution and acquisition speed. Here, we describe a real-time full mass range implementation of the phase-constrained spectrum d...
Acquisition and Analysis of DIA-Based Proteomic Data: A Comprehensive Survey in 2023 [0.03%]
基于DIA的蛋白质组学数据的获取与分析：2023年全面调查
Ronghui Lou,Wenqing Shui
Ronghui Lou
Data-independent acquisition (DIA) mass spectrometry (MS) has emerged as a powerful technology for high-throughput, accurate, and reproducible quantitative proteomics. This review provides a comprehensive overview of recent advances in both...
Recognition of Highly Branched N-Glycans of the Porcine Whipworm by the Immune System [0.03%]
猪鞭虫高度分枝的N-连接糖链的免疫系统识别
Barbara Eckmair,Chao Gao,Akul Y Mehta et al.
Barbara Eckmair et al.
Glycans are key to host-pathogen interactions, whereby recognition by the host and immunomodulation by the pathogen can be mediated by carbohydrate binding proteins, such as lectins of the innate immune system, and their glycoconjugate liga...