Accurate MS-based diagnostic amyloid typing using endogenously normalized protein intensities in formalin-fixed paraffin-embedded tissue [0.03%]
基于内源性归一化蛋白强度的准确的用于石蜡包埋组织的MS诊断淀粉样蛋白分型
Vanessa Hollfoth,Arslan Ali,Eyyub Bag et al.
Vanessa Hollfoth et al.
Amyloidoses are a group of diseases characterized by the pathological deposition of non-degradable misfolded protein fibrils, including those associated with plasma cell neoplasias, chronic inflammatory conditions, and age-related disorders...
Spatial proteomics reveals distinct protein patterns in cortical migration disorders caused by LIN28A overexpression and WNT activation [0.03%]
空间蛋白质组学揭示了由LIN28A过表达和WNT激活引起的皮层迁移障碍的不同蛋白质谱型
Jelena Navolić,Sara Hawass,Manuela Moritz et al.
Jelena Navolić et al.
Developmental signalling pathways act in stage and tissue dependent relation and mis-activation can drive tumour formation. The RNA-binding protein LIN28A binds to mRNA and miRNA and thereby affects the protein turnover and maintains stemne...
mTORC2 regulates non-homologous end joining through modulating the temporal dynamics of 53BP1 [0.03%]
mTORC2通过调节53BP1的动态变化调控非同源末端连接作用
Chunqing Wang,Hao Wang,Yunqiu Wang et al.
Chunqing Wang et al.
DNA damage repair is a critical biological process that maintains genomic integrity, and its dysregulation is closely related to tumorigenesis. To reveal the roles of mammalian target of rapamycin complex 2 (mTORC2) in DNA damage response (...
Professor D.F. Hunt relationship with Finnigan Corporation and His Impact on Mass Spectrometer Development [0.03%]
D.F.亨特教授与芬纳根公司的关系及其对质谱仪发展的影响
Michael S Story,George C Stafford,John E P Syka
Michael S Story
Don Hunt's 50-year collaboration with Finnigan Instruments Corporation has resulted in many innovations in mass spectrometry that range from new instrumentation to new analytical methodologies which in turn enabled new applications. The fru...
Multi-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines [0.03%]
BRCA1和BRCA2突变型乳腺癌细胞系中获得性奥拉帕利耐药的多组学特征分析
Holda A Anagho-Mattanovich,Meeli Mullari,Matthias Anagho-Mattanovich et al.
Holda A Anagho-Mattanovich et al.
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these ...
Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry [0.03%]
利用数据非依赖性采集质谱技术解析药物耐受BRAF突变黑色素瘤中支链未折叠蛋白反应的激活状态
Lea A Barny,Jake N Hermanson,Sarah K Garcia et al.
Lea A Barny et al.
Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three main branches-ATF6, IRE1, and PERK-that ...
Secretagogin Downregulation Impairs Nerve Cell Migration in Hirschsprung Disease via Inhibition of the LEF-1/NCAM1 Axis [0.03%]
分泌蛋白(secretagogin)下调通过抑制LEF-1/NCAM1轴损伤先天性巨结肠症神经细胞迁移
Yun Zhou,Shuiqing Chi,Shuai Li et al.
Yun Zhou et al.
Hirschsprung disease (HSCR) is a common peripheral neurodevelopmental disorder, and impaired enteric neural crest cell (ENCC) migration is one of the key factors. Secretagogin (SCGN) has been demonstrated to play a critical role in the rost...
Nucleolar proteomics revealed the regulation of RNA exosome localization by MTR4 [0.03%]
核糖体蛋白组学揭示MTR4对RNA外切酶定位调控作用
Yaqian Zhang,Guangzhen Jiang,Ke Wang et al.
Yaqian Zhang et al.
The nucleolus is the largest membrane-less organelle within the nucleus and plays critical roles in regulating the cell cycle, senescence, and stress responses. The RNA exosome is a multiprotein ribonucleolytic complex involved in RNA proce...
Deep Exploration of the Immunopeptidome of a Pancreatic Cancer Cell Line: Implications for Clinical Immunopeptidomics and Immunotherapy [0.03%]
胰腺癌细胞系免疫肽群的深入探索及其在临床免疫肽组学和免疫治疗中的应用意义
Mohammadreza Dorvash,Patricia T Illing,Nathan P Croft et al.
Mohammadreza Dorvash et al.
Pancreatic ductal adenocarcinoma (PDAC), with its devastating prognosis and limited treatment options, demands innovative therapeutic strategies. T-cell-based immunotherapy has shown promise for many cancers, including PDAC, but is limited ...
Nup93-Mediated RNA Alternative Splicing Associated with Diabetic Atherosclerosis [0.03%]
与糖尿病动脉粥样硬化相关的Nup93介导的RNA选择性剪接
Xiaojing Yuan,Qilun Zhang,Jie Li et al.
Xiaojing Yuan et al.
Atherosclerosis, a life-threatening complication of diabetes mellitus (DM), significantly increases the mortality risk among diabetic patients. Vascular smooth muscle cells (VSMCs) not only constitute the core of atherosclerotic lesions but...