Region-resolved integrative multi-omic characterization reveals diverse tumor and microenvironment features of pituitary neuroendocrine tumors [0.03%]
区域解析的整体多组学特征揭示了垂体神经内分泌肿瘤的多样性的肿瘤和微环境特征
Tao Xie,Qiang Xie,Qin Hu et al.
Tao Xie et al.
Pituitary neuroendocrine tumors are frequently invasive, with cavernous sinus invasion leading to poor treatment outcomes and high recurrence. Regional differences within these tumors remain poorly understood, hindering targeted therapy dev...
Non-canonical transcription and splicing shape the colorectal cancer immunopeptidome in MSI and MSS tumors [0.03%]
非典则转录和剪切塑造微卫星不稳定性和稳定型结直肠癌肿瘤的免疫肽组学
Mathieu Courcelles,Marie-Pierre Hardy,Chantal Durette et al.
Mathieu Courcelles et al.
Treatment with immune checkpoint inhibitors in colorectal cancer (CRC) has largely benefited patients with microsatellite instability-high (MSI-H) and not the larger proportion of patient with microsatellite-stable (MSS) tumors. This clinic...
Dynamic proximity networks of myosin-19 (Myo19) and its mitochondrial receptors Miro2 and metaxin-3 [0.03%]
肌球蛋白19(Myo19)及其线粒体受体Miro2和metaxin-3的动态接近网络
Aya Attia,Jürgen Eirich,Ulrike Honnert et al.
Aya Attia et al.
Myosin-19 (Myo19) plays a crucial role in mitochondrial dynamics, cristae organization and ER-mitochondria contact sites (ERMCS). It regulates cytokinesis and inheritance of mitochondria to daughter cells. To better understand the dynamic m...
An integrative proteomic approach to reveal altered signaling modules during Alzheimer's disease progression in PS19 tauopathy mice [0.03%]
一种集成蛋白质组学方法揭示PS19tauopathy小鼠在阿尔茨海默病进展过程中信号模块的变化
Eunji Cho,Seulah Lee,Hagyeong Lee et al.
Eunji Cho et al.
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease that is characterized by cognitive, functional, and behavioral impairments. These changes occur owing to the progressive accumulation of extracellular amyloid-beta p...
Proteome unravels mechanism differences in embryogenesis between honey bee drone and worker (Apis mellifera L.) [0.03%]
基于蜜蜂王子和工蜂胚胎发育蛋白质组探讨其机制差异性研究(Apis mellifera L.)
Beibei Ma,Jianke Li,Hesham R El-Seedi et al.
Beibei Ma et al.
The physiological and social behaviors differ widely between honey bee workers and drones. All the organ rudiments of adult bees are formed during the embryonic stage. The initial molecular bases at the proteomic level for both embryonic de...
Innovative CRISPR/Cas9-Based Strategy for Allele-Specific HLA Peptidome Analysis Using a Pan-HLA Antibody [0.03%]
一种基于CRISPR/Cas9的创新策略，利用全HLA抗体进行等位基因特异性HLA肽组分析
Laura Cobos-Figueroa,Ana Pintor-Poveda,Carmen Mir et al.
Laura Cobos-Figueroa et al.
Human leukocyte antigen (HLA) immunopeptidomics is restricted by the limited availability of allele-specific antibodies and by potential artifacts introduced by HLA overexpression systems. To address these challenges, we developed a CRISPR/...
4-Oxo-2-Nonenal Crosslinks Vicinal Cysteine-Lysine Pairs in Cellular Proteins [0.03%]
4-oxo-2-壬烯醛通过交联细胞蛋白中的蛋氨酸-赖氨酸对发挥功能
Ruifeng Cheng,Minran Wang,Keke Liu et al.
Ruifeng Cheng et al.
4-Oxo-2-nonenal (ONE) is a highly reactive aldehyde derived from endogenous lipid peroxidation, which is associated with the development and progression of chronic human diseases. Despite the fact that ONE exerts biological effects mainly b...
N-glycosylation of AXL receptor tyrosine kinase regulates its stability, phosphorylation and oncogenic function [0.03%]
AXL受体酪氨酸激酶的N-糖基化调控其稳定性、磷酸化和致癌功能
Li Wang,Lingrui Li,Jidong Wang et al.
Li Wang et al.
AXL, a receptor tyrosine kinase implicated in tumor progression, undergoes post-translational modifications that regulate its activity and stability. In this study, we demonstrated that AXL is extensively N-glycosylated in breast and ovaria...