SECRET AGENT O-GlcNAcylates Hundreds of Proteins Involved in Diverse Cellular Processes in Arabidopsis [0.03%]
秘密特工O-糖基化参与多种细胞过程的数百个蛋白在拟南芥中的作用
Ruben Shrestha,Sumudu Karunadasa,TaraBryn S Grismer et al.
Ruben Shrestha et al.
O-GlcNAcylation is a critical post-translational modification of proteins observed in both plants and animals and plays a key role in growth and development. While considerable knowledge exists about over 3000 substrates in animals, our und...
The Importance, Challenges, and Possible Solutions for Sharing Proteomics Data While Safeguarding Individuals' Privacy [0.03%]
在保护个人隐私的同时共享蛋白质组学数据的重要性、挑战及可能的解决方案
Mahasish Shome,Tim M G MacKenzie,Smitha R Subbareddy et al.
Mahasish Shome et al.
Proteomics data sharing has profound benefits at the individual level as well as at the community level. While data sharing has increased over the years, mostly due to journal and funding agency requirements, the reluctance of researchers w...
Chemical Proteomics Reveals Nε-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization [0.03%]
化学蛋白质组学揭示了邻近毒素的Rho灭活域(Vibrio MARTX毒素)通过使Septin发生Nε-脂肪酰化来改变Septin定位和组织结构的过程。
Yaxin Xu,Ke Ding,Tao Peng
Yaxin Xu
Vibrio species, the Gram-negative bacterial pathogens causing cholera and sepsis, produce multiple secreted virulence factors for infection and pathogenesis. Among these is the multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin t...
Antibody Profiling of Pan-Cancer Viral Proteome Reveals Biomarkers for Nasopharyngeal Carcinoma Diagnosis and Prognosis [0.03%]
泛癌症病毒蛋白质组的抗体分析揭示了鼻咽癌诊断和预后的生物标志物
Te Liang,Hao Chen,Lei Liu et al.
Te Liang et al.
Diagnosing, predicting disease outcome, and identifying effective treatment targets for virus-related cancers are lacking. Protein biomarkers have the potential to bridge the gap between prevention and treatment for these types of cancers. ...
Activity-Guided Proteomic Profiling of Proteasomes Uncovers a Variety of Active (and Inactive) Proteasome Species [0.03%]
通过活动指导的蛋白组学分析蛋白酶体，揭示了多种活跃（和不活跃）蛋白酶体类型
Manisha Priyadarsini Sahoo,Tali Lavy,Noam Cohen et al.
Manisha Priyadarsini Sahoo et al.
Proteasomes are multisubunit, multicatalytic protein complexes present in eukaryotic cells that degrade misfolded, damaged, or unstructured proteins. In this study, we used an activity-guided proteomic methodology based on a fluorogenic pep...
Michael A Gillette,Connie R Jimenez,Steven A Carr
Michael A Gillette
Epigenetic Mechanisms Histone Deacetylase-Dependent Regulate the Glioblastoma Angiogenic Matrisome and Disrupt Endothelial Cell Behavior In Vitro [0.03%]
表观遗传机制依赖组蛋白去乙酰化酶调节胶质母细胞瘤血管基质和扰乱体外内皮细胞行为
Aline Menezes,Glaucia Julião,Fernanda Mariath et al.
Aline Menezes et al.
Glioblastoma (GBM) is the most aggressive brain tumor and different efforts have been employed in the search for new drugs and therapeutic protocols for GBM. Epitranscriptomics has shed light on new druggable Epigenetic therapies specifical...
Modeling Flexible Protein Structure With AlphaFold2 and Crosslinking Mass Spectrometry [0.03%]
使用AlphaFold2和交联质谱法建模灵活的蛋白质结构
Karen Manalastas-Cantos,Kish R Adoni,Matthias Pfeifer et al.
Karen Manalastas-Cantos et al.
We propose a pipeline that combines AlphaFold2 (AF2) and crosslinking mass spectrometry (XL-MS) to model the structure of proteins with multiple conformations. The pipeline consists of two main steps: ensemble generation using AF2 and confo...
Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury [0.03%]
多组学分析鉴定小胶质细胞A2 annexin 是缺血再灌注损伤中NF-κB促炎信号的关键介质
Xibin Tian,Wuyan Yang,Wei Jiang et al.
Xibin Tian et al.
Cerebral stroke is one of the leading causes of mortality and disability worldwide. Restoring the cerebral circulation following a period of occlusion and subsequent tissue oxygenation leads to reperfusion injury. Cerebral ischemic reperfus...
TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice [0.03%]
TMEM225通过改变小鼠精子蛋白分布对精子成熟和男性生育力至关重要
Zheng Lv,Longjie Sun,Xiaomei Xie et al.
Zheng Lv et al.
Nonobstructive azoospermia is the leading cause of male infertility. Abnormal levels of transmembrane protein 225 (TMEM225), a testis-specific protein, have been found in patients with nonobstructive azoospermia, suggesting that TMEM225 pla...