Global Interactome Mapping Reveals Pro-tumorigenic Interactions of NF-κB in Breast Cancer [0.03%]
全球互作图谱揭示了乳腺癌中NF-κB的促肿瘤相互作用
Petr Lapcik,R Greg Stacey,David Potesil et al.
Petr Lapcik et al.
NF-κB pathway is involved in inflammation; however, recent data shows its role also in cancer development and progression, including metastasis. To understand the role of NF-κB interactome dynamics in cancer, we study the complexity of br...
pXg: Comprehensive Identification of Noncanonical MHC-I-Associated Peptides From De Novo Peptide Sequencing Using RNA-Seq Reads [0.03%]
pXg：利用从头肽序列测定和RNA序列读取全面识别非常规MHC-I相关肽段
Seunghyuk Choi,Eunok Paek
Seunghyuk Choi
Discovering noncanonical peptides has been a common application of proteogenomics. Recent studies suggest that certain noncanonical peptides, known as noncanonical major histocompatibility complex-I (MHC-I)-associated peptides (ncMAPs), tha...
Trenton M Peters-Clarke,Qiuwen Quan,Benton J Anderson et al.
Trenton M Peters-Clarke et al.
Therapeutic RNAs are routinely modified during their synthesis to ensure proper drug uptake, stability, and efficacy. Phosphorothioate (PS) RNA, molecules in which one or more backbone phosphates are modified with a sulfur atom in place of ...
Selective Modulation of the Human Glucocorticoid Receptor Compromises GR Chromatin Occupancy and Recruitment of p300/CBP and the Mediator Complex [0.03%]
人类糖皮质激素受体的选择性调节影响GR染色质占有率以及p300 / CBP和介质复合物的募集
Laura Van Moortel,Annick Verhee,Jonathan Thommis et al.
Laura Van Moortel et al.
Exogenous glucocorticoids are frequently used to treat inflammatory disorders and as adjuncts for the treatment of solid cancers. However, their use is associated with severe side effects and therapy resistance. Novel glucocorticoid recepto...
The Quantitative Biotinylproteomics Studies Reveal a WInd-Related Kinase 1 (Raf-Like Kinase 36) Functioning as an Early Signaling Component in Wind-Induced Thigmomorphogenesis and Gravitropism [0.03%]
定量生物素蛋白组学研究揭示了与风相关的激酶1（类似 Raf 激酶 36）在风诱导的触态形态建成和向重力性中作为早期信号成分的功能
Nan Yang,Jia Ren,Shuaijian Dai et al.
Nan Yang et al.
Wind is one of the most prevalent environmental forces entraining plants to develop various mechano-responses, collectively called thigmomorphogenesis. Largely unknown is how plants transduce these versatile wind force signals downstream to...
Personalized Drug Therapy: Innovative Concept Guided With Proteoformics [0.03%]
个性化药物治疗：由蛋白质形学指导的创新概念
Junwen Su,Lamei Yang,Ziran Sun et al.
Junwen Su et al.
Personalized medicine can reduce adverse effects, enhance drug efficacy, and optimize treatment outcomes, which represents the essence of personalized medicine in the pharmacy field. Protein drugs are crucial in the field of personalized dr...
Exploration of Nitrotyrosine-Containing Proteins and Peptides by Antibody-Based Enrichment Strategies [0.03%]
基于抗体的富集策略探索含硝基酪氨酸的蛋白质和肽
Firdous A Bhat,Kiran K Mangalaparthi,Husheng Ding et al.
Firdous A Bhat et al.
Nitrotyrosine, or 3-nitrotyrosine, is an oxidative post-translational modification induced by reactive nitrogen species. Although nitrotyrosine is considered a marker of oxidative stress and has been associated with inflammation, neurodegen...
Proximity Mapping of Desmosomes Reveals a Striking Shift in Their Molecular Neighborhood Associated With Maturation [0.03%]
邻近标记法描绘黏着斑分子分布揭示其在成熟过程中发生显著变化
Judith B Fülle,Rogerio Alves de Almeida,Craig Lawless et al.
Judith B Fülle et al.
Desmosomes are multiprotein adhesion complexes that link intermediate filaments to the plasma membrane, ensuring the mechanical integrity of cells across tissues, but how they participate in the wider signaling network to exert their full f...
Epitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) [0.03%]
氢氘交换质谱（HDX-MS）对脑膜炎奈瑟菌疫苗fHbp抗原人多克隆抗体表位 Mapping 的研究
Laura R Grauslund,Susanne Ständer,Daniele Veggi et al.
Laura R Grauslund et al.
Antigen-antibody interactions play a key role in the immune response post vaccination and the mechanism of action of antibody-based biopharmaceuticals. 4CMenB is a multicomponent vaccine against Neisseria meningitidis serogroup B in which f...
A Time Point Proteomic Analysis Reveals Protein Dynamics of Plasmodium Oocysts [0.03%]
时间点蛋白组学分析揭示了疟原虫卵囊的蛋白质动力学
Claude Marie François Preira,Elisabetta Pizzi,Federica Fratini et al.
Claude Marie François Preira et al.
The oocyst is a sporogonic stage of Plasmodium development that takes place in the mosquito midgut in about 2 weeks. The cyst is protected by a capsule of unknown composition, and little is known about oocyst biology. We carried out a prote...