Proteomics-Derived Biomarker Panel Facilitates Distinguishing Primary Lung Adenocarcinomas With Intestinal or Mucinous Differentiation From Lung Metastatic Colorectal Cancer [0.03%]
基于蛋白质组学的生物标志物谱有助于区分原发性肺腺癌肠或粘液分化和肺转移性结直肠癌
Jiaying Liu,Xiaona Chang,Liujia Qian et al.
Jiaying Liu et al.
The diagnosis of primary lung adenocarcinomas with intestinal or mucinous differentiation (PAIM) remains challenging due to the overlapping histomorphological, immunohistochemical (IHC), and genetic characteristics with lung metastatic colo...
Comprehensive Proteomics Analysis of Polyhydroxyalkanoate (PHA) Biology in Pseudomonas putida KT2440: The Outer Membrane Lipoprotein OprL is a Newly Identified Phasin [0.03%]
荧光定量法分析恶臭假单胞菌聚羟基脂肪酸生物学：外膜脂蛋白OprL是一种新鉴定的PhaZ酶
Siobhan Kelly,Jia-Lynn Tham,Kate McKeever et al.
Siobhan Kelly et al.
Pseudomonas putida KT2440 is an important bioplastic-producing industrial microorganism capable of synthesizing the polymeric carbon-rich storage material, polyhydroxyalkanoate (PHA). PHA is sequestered in discrete PHA granules, or carbonos...
TIMAHAC: Streamlined Tandem IMAC-HILIC Workflow for Simultaneous and High-Throughput Plant Phosphoproteomics and N-glycoproteomics [0.03%]
TIMAHAC：一种简化的串联IMAC-HILIC工作流程，用于同时进行高通量植物磷酸蛋白质组学和N-糖蛋白组学研究
Chin-Wen Chen,Pei-Yi Lin,Ying-Mi Lai et al.
Chin-Wen Chen et al.
Protein post-translational modifications (PTMs) are crucial in plant cellular processes, particularly in protein folding and signal transduction. N-glycosylation and phosphorylation are notably significant PTMs, playing essential roles in r...
Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation [0.03%]
多组学分析食管腺癌发现潜在治疗靶点及癌症选择性转录后调控
J Robert O&#x;Neill,Marcos Yébenes Mayordomo,Goran Mitulović et al.
J Robert O&#x;Neill et al.
Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutation...
Systematic Investigation of the Trafficking of Glycoproteins on the Cell Surface [0.03%]
细胞表面糖蛋白运输的系统研究
Xing Xu,Kejun Yin,Ronghu Wu
Xing Xu
Glycoproteins located on the cell surface play a pivotal role in nearly every extracellular activity. N-glycosylation is one of the most common and important protein modifications in eukaryotic cells, and it often regulates protein folding ...
Lia R Serrano,Trenton M Peters-Clarke,Tabiwang N Arrey et al.
Lia R Serrano et al.
We describe deep analysis of the human proteome in less than 1 h. We achieve this expedited proteome characterization by leveraging state-of-the-art sample preparation, chromatographic separations, and data analysis tools, and by using the ...
Proteomics Impact on Cell Biology to Resolve Cell Structure and Function [0.03%]
蛋白质组学对细胞生物学的影响：解析细胞结构与功能
John J M Bergeron
John J M Bergeron
The acceleration of advances in proteomics has enabled integration with imaging at the EM and light microscopy levels, cryo-EM of protein structures, and artificial intelligence with proteins comprehensively and accurately resolved for cell...
Søren Heissel,Yi He,Andris Jankevics et al.
Søren Heissel et al.
Recombinant expression of proteins, propelled by therapeutic antibodies, has evolved into a multibillion dollar industry. Essential here is the quality control assessment of critical attributes, such as sequence fidelity, proper folding, an...
Assessment of Kinome-Wide Activity Remodeling upon Picornavirus Infection [0.03%]
评估皮托病毒感染下的激酶组范围内的活性重塑
Tim S Veth,Lonneke V Nouwen,Marleen Zwaagstra et al.
Tim S Veth et al.
Picornaviridae represent a large family of single-stranded positive RNA viruses of which different members can infect both humans and animals. These include the enteroviruses (e.g., poliovirus, coxsackievirus, and rhinoviruses) as well as t...
Dynamic Proteomic Changes in Tumor and Immune Organs Reveal Systemic Immune Response to Tumor Development [0.03%]
肿瘤及免疫器官的蛋白组动态变化揭示机体对肿瘤发展的免疫响应机制
Zhike Li,Shuwen Liu,Zhouyong Gao et al.
Zhike Li et al.
In orthotopic mouse tumor models, tumor progression is a complex process, involving interactions among tumor cells, host cell-derived stromal cells, and immune cells. Much attention has been focused on the tumor and its tumor microenvironme...